Transverse myelitis associated with Zika virus infection: a Case Report

Title: Transverse myelitis associated with Zika virus infection: a Case Report.: The zika virus belongs to the family flaviviridae, and is transmitted by the arthropod Aedes aegypt. Its major importance is related to the several debilitating neurological manifestations associated with it, such as transverse myelitis. Case: The authors report a case of transverse myelitis in a patient with a previous diagnosis of Zika virus infection. After the image exams and serology, the diagnosis was confirmed and treatment with prednisone was performed with an unsatisfactory clinical outcome. Conclusion: Brazil is the country of greatest concern worldwide due to the thousands of Zika cases with associated neurological complications, causing sequels and physical disabilities. However, cases worldwide have increased substantially.

Download Full-text

Poster 363: Transverse Myelitis Caused by Zika Virus Infection in the Caribbean: A Case Report

PM&R ◽

10.1016/j.pmrj.2017.08.302 ◽

2017 ◽

Vol 9 ◽

pp. S247-S247 ◽

Cited By ~ 1

Author(s):

Rafael A. Romeu-Mejia ◽

Joanne M. Delgado-Lebron ◽

Eduardo Nadal-Ortiz

Keyword(s):

Case Report ◽

Virus Infection ◽

Zika Virus ◽

Transverse Myelitis ◽

Zika Virus Infection ◽

The Caribbean

Download Full-text

Case Report: Acute Transverse Myelitis after Zika Virus Infection

American Journal of Tropical Medicine and Hygiene ◽

10.4269/ajtmh.17-0938 ◽

2018 ◽

Vol 99 (6) ◽

pp. 1419-1421 ◽

Cited By ~ 5

Author(s):

Vanderson Carvalho Neri ◽

Maria Filomena Xavier ◽

Priscila Oliveira Barros ◽

Cleonice Melo Bento ◽

Romain Marignier ◽

...

Keyword(s):

Case Report ◽

Virus Infection ◽

Zika Virus ◽

Transverse Myelitis ◽

Acute Transverse Myelitis ◽

Zika Virus Infection

Download Full-text

The P-MAPA immunomodulator partially prevents apoptosis induced by Zika virus infection in THP-1 cells

Current Pharmaceutical Biotechnology ◽

10.2174/1389201021666200602140005 ◽

2020 ◽

Vol 21 ◽

Cited By ~ 1

Author(s):

Morganna C. Lima ◽

Elisa A. N. Azevedo ◽

Clarice N. L. de Morais ◽

Larissa I. O. de Sousa ◽

Bruno M. Carvalho ◽

...

Keyword(s):

Cell Proliferation ◽

Cell Death ◽

Virus Infection ◽

Virus Replication ◽

Zika Virus ◽

Mammalian Cells ◽

Caspase 3 ◽

Neurological Complications ◽

Zika Virus Infection

Background: Zika virus is an emerging arbovirus of global importance. ZIKV infection is associated with a range of neurological complications such as the Congenital Zika Syndrome and Guillain Barré Syndrome. Despite the magnitude of recent outbreaks, there is no specific therapy to prevent or to alleviate disease pathology. Objective: To investigate the role of P-MAPA immunomodulator in Zika-infected THP-1 cells. Methods: THP-1 cells were subjected at Zika virus infection (Multiplicity of Infection = 0.5) followed by treatment with P-MAPA for until 96 hours post-infection. After that, the cell death was analyzed by annexin+/ PI+ and caspase 3/ 7+ staining by flow cytometry. In addition, the virus replication and cell proliferation were accessed by RT-qPCR and Ki67 staining, respectively. Results: We demonstrate that P-MAPA in vitro treatment significantly reduces Zika virus-induced cell death and caspase-3/7 activation on THP-1 infected cells, albeit it has no role in virus replication and cell proliferation. Conclusions: Our study reveals that P-MAPA seems to be a satisfactory alternative to inhibits the effects of Zika virus infection in mammalian cells.

Download Full-text

Neurological Complications of Congenital Zika Virus Infection

Pediatric Neurology ◽

10.1016/j.pediatrneurol.2018.11.003 ◽

2019 ◽

Vol 91 ◽

pp. 3-10 ◽

Cited By ~ 13

Author(s):

Vinícius de Melo Marques ◽

Camilla Sousa Santos ◽

Isabella Godinho Santiago ◽

Solomar Martins Marques ◽

Maria das Graças Nunes Brasil ◽

...

Keyword(s):

Virus Infection ◽

Zika Virus ◽

Neurological Complications ◽

Zika Virus Infection

Download Full-text

Seroprevalence of Zika virus in selected regions in Kenya

Transactions of the Royal Society of Tropical Medicine and Hygiene ◽

10.1093/trstmh/trz077 ◽

2019 ◽

Vol 113 (12) ◽

pp. 735-739 ◽

Cited By ~ 5

Author(s):

Bramuel Kisuya ◽

Moses M Masika ◽

Esto Bahizire ◽

Julius O Oyugi

Keyword(s):

Virus Infection ◽

Zika Virus ◽

Healthy Adult ◽

Neurological Complications ◽

Previous Exposure ◽

Limited Data ◽

Zika Virus Infection ◽

Human Sera ◽

Study Population ◽

The University

Abstract Background The Zika virus pandemic in South America in 2015–2016 and the association of Zika virus infection with neurological complications such as microcephaly in newborns distressed the global community. There is limited data on the prevalence of Zika virus in Kenya despite evidence of its circulation in East Africa. This study aimed at assessing the seroprevalence of Zika virus in selected areas in Kenya. Methods Healthy adult human sera originally collected from Nairobi, Eldoret and Kisumu from 2009 to 2014 and archived at the University of Nairobi laboratories were examined for Zika virus antibodies. An IgG-based ELISA was used to screen 577 sera. Any serum tested positive by ELISA was confirmed for Zika virus infection by plaque reduction neutralization test (PRNT). Results The seroprevalence of Zika virus in the study population was about 0.2 % (1/577) as confirmed by PRNT. Additionally, three sera that were false positive by ELISA for Zika virus were confirmed as positive for dengue virus by PRNT. Conclusion There was evidence of low previous exposure to Zika virus in the study population. Of the three regions in Kenya where sera for this study were obtained, only Kisumu County had one case of previous exposure to Zika virus.

Download Full-text