Insulinoma and Prolactinoma in a Young Female: A Variant of Multiple Endocrine Neoplasia 1 (MEN-1)

2010 ◽  
Vol 47 (3) ◽  
Author(s):  
Marbert John T Cardino ◽  
Frances Lina Lantion-Ang
Keyword(s):  
Multiple Endocrine Neoplasia ◽  
Young Female ◽  
Men 1 ◽  
Endocrine Neoplasia ◽  
Multiple Endocrine Neoplasia 1

scholarly journals Extreme Nausea due to Hyperparathyroidism in Multiple Endocrine Neoplasia-1

2015 ◽  
Vol 7 (3) ◽  
pp. 69-71
Author(s):  
Geoffrey B Thompson ◽  
TK Pandian ◽  
Dy Benzon
Keyword(s):  
Multiple Endocrine Neoplasia ◽  
Symptom Control ◽  
Relevant Literature ◽  
Pancreatic Head ◽  
Severe Nausea ◽  
Subtotal Parathyroidectomy ◽  
Men 1 ◽  
Endocrine Neoplasia ◽  
High Calcium ◽  
Multiple Endocrine Neoplasia 1

ABSTRACT We describe a young woman with multiple endocrine neoplasia-1 (MEN-1) who presented with severe nausea as a result of hyperparathyroidism (HPT). We present a case report, review the relevant literature in regards to physiology, and offer a target source for symptom control. A 19-year female with MEN-1 initially presented with neuroglycopenia and hyperinsulinism. She had concomitant HPT. She underwent a distal pancreatectomy with enucleation of neuroendocrine tumors from the pancreatic head. Postoperatively, she developed severe nausea and was found to have worsening HPT. She was placed on a calcimimetic and had immediate resolution of symptoms. She ultimately underwent a subtotal parathyroidectomy and has been symptom-free since that time. Severe nausea can occur in up to 25% of patients with HPT. Two theories exist regarding the mechanism behind this symptomatology. The first involves destruction of gastric mucosa leading to peptic ulcer disease. The second suggests that the etiology is gastrointestinal atony due to high calcium levels or parathyroid hormone (PTH). Based on the available data, therapies to treat nausea in HPT should focus on decreasing high levels of calcium. How to cite this article Pandian TK, Thompson G, Benzon Dy. Extreme Nausea due to Hyperparathyroidism in Multiple Endocrine Neoplasia-1. World J Endoc Surg 2015;7(3):69-71.

Multiple Endocrine Neoplasia-1 (MEN-1) Presenting as Primary Hyperaldosteronism

2008 ◽  
Vol 18 (2) ◽  
pp. 68-70
Author(s):  
Anil Bhansali ◽  
G V. Chanukya ◽  
Sanjay Kumar Bhadada ◽  
Arunanshu Behera ◽  
Bishan Das Radotra
Keyword(s):  
Multiple Endocrine Neoplasia ◽  
Primary Hyperaldosteronism ◽  
Men 1 ◽  
Endocrine Neoplasia ◽  
Multiple Endocrine Neoplasia 1

Challenges in the differential diagnosis of multiple endocrine neoplasia syndrome type 1 with isolated family hyperparathyroidism

2020 ◽  
Vol 98 (3) ◽  
pp. 218-225
Author(s):  
J. A. Krupinova ◽  
N. G. Mokrysheva ◽  
N. Y. Kalinchenko ◽  
A. K. Eremkina ◽  
A. N. Polyakov ◽  
...  
Keyword(s):  
Multiple Endocrine Neoplasia ◽  
Molecular Genetic ◽  
Pancreatic Neuroendocrine Tumor ◽  
Family Type ◽  
Dynamic Monitoring ◽  
Heterozygous Mutation ◽  
Molecular Genetic Study ◽  
Men 1 ◽  
Endocrine Neoplasia

Multiple endocrine neoplasia type 1 (MEN-1) is the most common cause of the hereditary type of primary hyperparathyroidism (PHPT). If a family type of PHPT is suspected, a dynamic monitoring of patients and their close relatives should be carried out throughout their lives. We present a clinical case of a family in which four members of a pedigree were diagnosed with familial isolated hyperparathyroidism (FIHP). The diagnosis was changed to MEN-1, because it appeared that one of the patients had pancreatic neuroendocrine tumor. Molecular genetic study of MEN1 by direct by means of Sanger sequencing revealed that six family members had a new heterozygous mutation in exon 9: s. 1252 G> T p. D418Y.

scholarly journals Myasthenia gravis and thymoma in multiple endocrine neoplasia (MEN-1) syndrome.

1990 ◽  
Vol 53 (7) ◽  
pp. 624-625 ◽  
Author(s):  
L J Vroegindeweij-Claessens ◽  
C C Tijssen ◽  
G J Creemers ◽  
J H Lockefeer ◽  
J L Teepen
Keyword(s):  
Myasthenia Gravis ◽  
Multiple Endocrine Neoplasia ◽  
Men 1 ◽  
Endocrine Neoplasia
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