scholarly journals Heterozygous Thr 135 Ala polymorphism at leucine-rich repeat (LRR) in genomic DNA of toll-like receptor 4 in patients with poorly-differentiated gastric adenocarcinomas

2006 ◽  
Author(s):  
Tadashi Ohara ◽  
Tetsuo Morishita ◽  
Hidekazu Suzuki ◽  
Toshifumi Hibi
Keyword(s):  
Genomic Dna ◽  
Leucine Rich Repeat ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4 ◽  
Gastric Adenocarcinomas ◽  
Poorly Differentiated

scholarly journals An inhibitory epitope of human Toll‐like receptor 4 resides on leucine‐rich repeat 13 and is recognized by a monoclonal antibody

FEBS Letters ◽  
2017 ◽  
Vol 591 (18) ◽  
pp. 2953-2953
Author(s):  
Hiroki Tsukamoto ◽  
Yuki Yamagata ◽  
Ippo Ukai ◽  
Shino Takeuchi ◽  
Misaki Okubo ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Leucine Rich Repeat ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4

scholarly journals An inhibitory epitope of human Toll-like receptor 4 resides on leucine-rich repeat 13 and is recognized by a monoclonal antibody

FEBS Letters ◽  
2017 ◽  
Vol 591 (16) ◽  
pp. 2406-2416 ◽  
Author(s):  
Hiroki Tsukamoto ◽  
Yuki Yamagata ◽  
Ippo Ukai ◽  
Shino Takeuchi ◽  
Misaki Okubo ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Leucine Rich Repeat ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4

scholarly journals MD-2, a Molecule that Confers Lipopolysaccharide Responsiveness on Toll-like Receptor 4

1999 ◽  
Vol 189 (11) ◽  
pp. 1777-1782 ◽  
Author(s):  
Rintaro Shimazu ◽  
Sachiko Akashi ◽  
Hirotaka Ogata ◽  
Yoshinori Nagai ◽  
Kenji Fukudome ◽  
...  
Keyword(s):  
Recipient Cell ◽  
Receptor Complex ◽  
Leucine Rich Repeat ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4 ◽  
Low Responders ◽  
Tlr4 Gene ◽  
Mammalian Homologue ◽  
Lps Signaling ◽  
Pathophysiologic Mechanisms

Toll-like receptor 4 (TLR4) is a mammalian homologue of Drosophila Toll, a leucine-rich repeat molecule that can trigger innate responses against pathogens. The TLR4 gene has recently been shown to be mutated in C3H/HeJ and C57BL/10ScCr mice, both of which are low responders to lipopolysaccharide (LPS). TLR4 may be a long-sought receptor for LPS. However, transfection of TLR4 does not confer LPS responsiveness on a recipient cell line, suggesting a requirement for an additional molecule. Here, we report that a novel molecule, MD-2, is requisite for LPS signaling of TLR4. MD-2 is physically associated with TLR4 on the cell surface and confers responsiveness to LPS. MD-2 is thus a link between TLR4 and LPS signaling. Identification of this new receptor complex has potential implications for understanding host defense, as well as pathophysiologic, mechanisms.

scholarly journals Leucine-rich repeat 2 of human Toll-like receptor 4 contains the binding site for inhibitory monoclonal antibodies

FEBS Letters ◽  
2015 ◽  
Vol 589 (24PartB) ◽  
pp. 3893-3898 ◽  
Author(s):  
Hiroki Tsukamoto ◽  
Ippo Ukai ◽  
Yuki Yamagata ◽  
Shino Takeuchi ◽  
Kanae Kubota ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Binding Site ◽  
Leucine Rich Repeat ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4

660 Deficiency of Toll-like receptor 4 leads to cardioprotection against doxorubicin-induced cardiomyopathy

2007 ◽  
Vol 6 (1) ◽  
pp. 142-143
Author(s):  
A RIAD ◽  
S BIEN ◽  
M GRATZ ◽  
S BERESWILL ◽  
H SCHULTHEISS ◽  
...  
Keyword(s):  
Toll Like Receptor ◽  
Toll Like Receptor 4

Tanshinone IIA attenuates elastase-induced AAA in rats via inhibition of MyD88-dependent TLR-4 signaling

VASA ◽  
2014 ◽  
Vol 43 (1) ◽  
pp. 39-46 ◽  
Author(s):  
Tao Shang ◽  
Feng Ran ◽  
Qian Qiao ◽  
Zhao Liu ◽  
Chang-Jian Liu
Keyword(s):  
Nuclear Factor Κb ◽  
Tanshinone Iia ◽  
Myeloid Differentiation ◽  
Aortic Tissue ◽  
Toll Like Receptor ◽  
Sprague Dawley ◽  
Toll Like Receptor 4 ◽  
Tissue Samples ◽  
Myeloid Differentiation Factor ◽  
And Control

Background: The purpose of this study was to determine whether myeloid differentiation factor88-dependent Toll-Like Receptor-4 (TLR-4) signaling contributed to the inhibition of abdominal aortic aneurysm (AAA) by Tanshinone IIA (Tan IIA). Materials and methods: Male Sprague-Dawley rats (n = 12 / group) were randomly distributed into three groups: Tan IIA, control, and sham. The rats from Tan IIA and control groups under-went intra-aortic elastase perfusion to induce AAAs, and those in the sham group were perfused with saline. Only the Tan IIA group received Tan IIA (2 mg / rat / d). Aortic tissue samples were harvested at 24 d after perfusion and evaluated using reverse transcriptase-polymerase chain reaction, Western blot, immunohistochemistry and immunofluorescence. Results: The over-expression of Toll-Like Receptor-4 (TLR-4), Myeloid Differentiation factor 88 (MyD88), Phosphorylated Nuclear Factor κB (pNF-κB) and Phosphorylated IκBα (pIκBα) induced by elastase perfusion were significantly decreased by Tan IIA treatment. Conclusions: Tan IIA attenuates elastase-induced AAA in rats possibly via the inhibition of MyD88-dependent TLR-4 signaling, which may be one potential explanation of why Tan IIA inhibits AAA development through multiple effects.

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