scholarly journals Characteristic genes in THP‑1 derived macrophages infected with Mycobacterium tuberculosis H37Rv strain identified by integrating bioinformatics methods

2019 ◽  
Author(s):  
Yu‑Wei Zhang ◽  
Yan Lin ◽  
Hui‑Yuan Yu ◽  
Ruo‑Nan Tian ◽  
Fan Li
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Tuberculosis H37rv ◽  
Mycobacterium Tuberculosis H37rv ◽  
H37rv Strain

SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME NEW 1,3,4- OXADIAZOLES, 1,2,4-TRIAZOLES AND 1,3,4-THIADIAZOLES

INDIAN DRUGS ◽  
2016 ◽  
Vol 53 (06) ◽  
pp. 18-23
Author(s):  
U. V. Laddi ◽  
◽  
S. R. Desai
Keyword(s):  
Escherichia Coli ◽  
Antimicrobial Activity ◽  
Mycobacterium Tuberculosis ◽  
Antitubercular Activity ◽  
Tuberculosis H37rv ◽  
Research Centre ◽  
Methyl Ethyl ◽  
Rhizoctonia Bataticola ◽  
Mycobacterium Tuberculosis H37rv ◽  
H37rv Strain

Some new 5-[(((α-phenyl/methyl)benzylidene)amino)oxy]methyl/ethyl-2-[4-(substituted aryl)/allyl)] amino-1,3,4-oxadiazoles (4a-p), 3-[(((α-phenyl/methyl)- benzylidene) amino)oxy]methyl/ethyl-4-(4- substitutedaryl)/allyl-5-mercapto-1,2,4-triazoles (5a-p) and 5-[(((α-phenyl/methyl)-benzylidene)amino) oxy]- methyl/ethyl-2-[4-(substituted aryl)/allyl)]amino-1,3,4-thiadiazoles (6a-p) were prepared starting from α/β-[((α-(phenyl/methyl)benzylidene)amino)oxy acetic/propionic acid hydrazides (1a-d). The structures of all the compounds have been established by elemental and spectral (IR, 1HNMR and mass) analysis. All the newly synthesised compounds have been screened for their antimicrobial activity against Escherichia coli, Bacillus cirroflagellosus, Aspergillus niger and Rhizoctonia bataticola. Some of the newly synthesised compounds have been evaluated for antituberculosis activity against Mycobacterium tuberculosis H37Rv strain by BACTEC radiometric system at Southern Research Institute, Birmingham, AL and Frederick Research Centre, Frederick, MD. Significant antimicrobial activity is observed against Escherichia coli and Rhizoctonia bataticola. A few compounds also exhibited interesting antitubercular activity against Mycobacterium tuberculosis H37Rv strain.

scholarly journals Design and characterisation of piperazine-benzofuran integrated dinitrobenzenesulfonamide as Mycobacterium tuberculosis H37Rv strain inhibitors

2021 ◽  
Vol 36 (1) ◽  
pp. 1751-1759
Author(s):  
Vallabhaneni S. Murthy ◽  
Yasinalli Tamboli ◽  
Vagolu Siva Krishna ◽  
Dharmarajan Sriram ◽  
Siddique Akber Ansari ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Tuberculosis H37rv ◽  
Mycobacterium Tuberculosis H37rv ◽  
H37rv Strain

scholarly journals ANTITUBERCULAR ACTIVITY OF SOME NEWER 6-PYRIDAZINONE DERIVATIVES

2011 ◽  
Vol 19 (19) ◽  
pp. 17-23
Author(s):  
Asif HUSAIN ◽  
Aftab AHMAD ◽  
Anil BHANDARI ◽  
Veerma RAM
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Antitubercular Activity ◽  
Tuberculosis H37rv ◽  
Mycobacterium Tuberculosis H37rv ◽  
H37rv Strain ◽  
Pyridazinone Derivatives

Two series of 6-pyridazinone derivatives (17-30) were synthesized and evaluated for antitubercular activities against the Mycobacterium tuberculosis H37Rv strain. The results indicated that among the synthesized compounds, 5-( 4-hydroxy-3-methoxybenzyl}-3-phenyl-1,6-dihydro-6-pyridazinone (23) showed good antitubercular activity. Three more compounds, (18, 25 & 27) were significant in their antitubercular action. The present study reveals the antitubercular potential of 6-pyridazinones.

scholarly journals Potentialy Of Flavonoid Miana (Coleus Atropurpereus) Leaves Estract As Anti Mycobacterium Tuberculosis H37rv Strain And Mdr With Microscopy Observation Drug Susceptibility (Mods)

2018 ◽  
Vol 9 (2) ◽  
Author(s):  
Anita Anita ◽  
Dewi Arisanti ◽  
Andi Fatmawati
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Qualitative Method ◽  
Drug Susceptibility ◽  
Tuberculosis H37rv ◽  
Mycobacterium Tuberculosis H37rv ◽  
Resistant Tuberculosis ◽  
South Sulawesi ◽  
H37rv Strain ◽  
Mdr Tb ◽  
All Diseases

There is high resistance cases for Isoniazid and Rifampin and more famous withMulti-drug resistant tuberculosis (MDR-TB). From data in Makassar, South sulawesishowed 19,2 MDR-TB cases from new TB patient, and more 13,5% resistance cases forfirstline-TB drugs (STR, INH, RIF,and ETH), and >2 resistance for secondline-TBdrugs (OFL,KAN,AMK). Treatment for tuberculosis mostlly not effective because Multidrugresistanttuberculosis (MDR-TB) cases is very high.WHO recomended traditionalmedicine for improvement of healthy in coummunity, preventive and pharmaceuticalpreparation for all diseases. Research in 2013 showed 85,71% that Torajas TB patientin South Sulawesi used traditional medicine such as Miana (Coleus atropurpereus)leaves estract as complement for TB drugs. Our study showed flavonoid component fromqualitative method used sianida (HCl-Mg) from ethanol 96% Miana (Coleusatropurpereus) leaves estract .Qualitative method using Spektrofotometer UV-V showedthe total of flavonoid component from ethanol 96% miana (Coleus atropurpereus) leavesestract is 8,59 mgRE/gram ekstract.. The result showed were at concentrations (10%,20% ,40 % , 60 % ,80 % and 100%) ethanol 96% miana (Coleus atropurpereus) leavesestract were effecttively inhibit Mycobacterium tuberculosis H37RV strain. Were atconcentration (10%, 20% ,40 % dan 60 %) ethanol 96% miana (Coleus atropurpereus)leaves estract were not effecttively inhibit MDR-TB but effecttively were at concentration (80 % and 100%).

scholarly journals Molecular characterization of secretory proteins Rv3619c and Rv3620c from Mycobacterium tuberculosis H37Rv

FEBS Journal ◽  
2010 ◽  
Vol 278 (2) ◽  
pp. 341-353 ◽  
Author(s):  
Anjum Mahmood ◽  
Shubhra Srivastava ◽  
Sarita Tripathi ◽  
Mairaj Ahmed Ansari ◽  
Mohammad Owais ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Molecular Characterization ◽  
Tuberculosis H37rv ◽  
Secretory Proteins ◽  
Mycobacterium Tuberculosis H37rv
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