scholarly journals Impact of the alterations in the interstitial cells of Cajal on intestinal motility in post-infection irritable bowel syndrome

2014 ◽  
Vol 11 (4) ◽  
pp. 2735-2740 ◽  
Author(s):  
BO YANG ◽  
XU-CHUN ZHOU ◽  
CHENG LAN
2011 ◽  
Vol 25 (5) ◽  
pp. 277-279 ◽  
Author(s):  
Ahad Eshraghian ◽  
Hamed Eshraghian

Irritable bowl syndrome (IBS) affects a large proportion of the world’s population, and accounts for a considerable number of visits to gastroenterologists and general practitioners. Despite its high prevalence, the precise mechanism of IBS has not been identified to date. The interstitial cells of Cajal (ICC) participate in the production of slow waves and the regulation of their propagation through the gastrointestinal system; thus, they are important components of gastrointestinal motility. The present review proposes that ICC play a central role in the pathophysiology of IBS. This hypothesis is based on many links between ICC and currently proposed mechanisms of IBS pathophysiology. It appears that ICC may be involved in almost all of the previously explained pathogenic mechanisms of IBS. If proven, this hypothesis may provide a key to solving the IBS mystery.


2010 ◽  
Vol 588 (7) ◽  
pp. 1153-1169 ◽  
Author(s):  
Rachael R. Roberts ◽  
Melina Ellis ◽  
Rachel M. Gwynne ◽  
Annette J. Bergner ◽  
Martin D. Lewis ◽  
...  

2017 ◽  
Vol 9 (2) ◽  
pp. 172-181
Author(s):  
Limei Zhang ◽  
Jing Zeng ◽  
Yuanyuan Ma ◽  
Min Tan ◽  
Min Zhou ◽  
...  

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