scholarly journals Clinical value of color Doppler ultrasound combined with serum tumor markers for the diagnosis of medullary thyroid carcinoma

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Xue Yang ◽  
Jinjuan Xu ◽  
Jilan Sun ◽  
Lizhi Yin ◽  
Rui Guo ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Tumor Markers ◽  
Doppler Ultrasound ◽  
Color Doppler ◽  
Color Doppler Ultrasound ◽  
Clinical Value ◽  
Medullary Thyroid ◽  
Serum Tumor Markers

Calcitonin and Carcinoembryonic Antigen as Tumor Markers in Medullary Thyroid Carcinoma

1978 ◽  
Vol 70 (4) ◽  
pp. 587-594 ◽  
Author(s):  
Ronald A. Delellis ◽  
Allyn H. Rule ◽  
Ira Spiler ◽  
Larry Nathanson ◽  
Armen H. Tashjian ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Carcinoembryonic Antigen ◽  
Medullary Thyroid Carcinoma ◽  
Tumor Markers ◽  
Medullary Thyroid

scholarly journals The Importance of Lymph Node Dissection in Medullary Thyroid Carcinoma Management

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. A901-A902
Author(s):  
Camila Alejandra Villavicencio ◽  
Alberto Franco-Akel ◽  
Regina Belokovskaya
Keyword(s):  
Thyroid Carcinoma ◽  
Total Thyroidectomy ◽  
Neck Dissection ◽  
Medullary Thyroid Carcinoma ◽  
Tumor Markers ◽  
Lateral Neck ◽  
Lateral Neck Dissection ◽  
Medullary Thyroid ◽  
Preoperative Ct

Abstract Medullary thyroid carcinoma (MTC) is a rare endocrine malignancy that arises from calcitonin (Ct) parafollicular C-cells. Most cases are sporadic with frequent presentation being a solitary thyroid nodule. Total thyroidectomy with central neck dissection of lymph nodes (LN) is the standard treatment for MTC. The need for lateral neck dissection is controversial, with poor efficacy of non-surgical treatments presenting a problem. We present a case of MTC with preoperative Ct >500 pg/mL and negative imaging for metastases who underwent total thyroidectomy without LN exploration with an excellent postoperative biochemical response. This is a case of a 52-year-old female with a three-year history of anterior neck growth. The repeat fine needle aspiration (FNA) of a, previously negative for malignancy, growing nodule was consistent with MTC. Preoperative Ct and CEA levels were significantly elevated, 834.0 pg/mL and 11.2 ng/dL, respectively; a preoperative pan- CT scan did not reveal any suspicious LN or metastatic lesions and a negative RET oncogene mutation with normal plasma normetanephrines and metanephrines suggested a spontaneous rather than familial MTC. Patient underwent total thyroidectomy without LN exploration. Pathology confirmed MTC stage T1b. The one and three months postoperative follow up showed a significant downtrend with no normalization of Ct and CEA levels, 9.1 – 9.2 and 11.1 – 1.2, respectively. Reoperation for central and lateral neck dissection was considered; however, given the excellent biochemical response as well as the lack of radiographic evidence of disease, it was decided to continue monitoring of Ct and CEA levels for now. MTC response is monitored by the postoperative serum Ct and CEA levels when compared to the preoperative values. Serum Ct serves as a sensitive tumor marker, which is thought to have correlation with malignancy mass size and its cellular differentiation. The term biochemically cured, refers to the postoperative normalization of CEA and undetectable levels of Ct which carries a 5-year recurrence of 5%. It is believed that the higher the levels and the faster doubling time of these tumor markers the worse is the prognosis. In addition, it is suggested that patient’s age and extent of disease at the time of surgery are proportionally correlated with disease recurrence. However, there are reports of large MTC metastatic deposits with low serum Ct and CEA, rising up the hypothesis that levels reflect cell production potential for tumor markers rather than the number of cells. Reoperation rarely results in biochemical cure, but it may slow disease progression. Normal postoperative Ct levels predict cure; however, the clinical course of those with upper normal limit levels postoperatively is markedly variable. Careful regular biochemical and imaging follow-up will be of the utmost importance for the patient presented in this case.

scholarly journals The Diagnostic Value of Ultrasound in Medullary Thyroid Carcinoma: A Comparison With Computed Tomography

2020 ◽  
Vol 19 ◽  
pp. 153303382090583
Author(s):  
Liang Wang ◽  
Hongju Kou ◽  
Wei Chen ◽  
Mingdong Lu ◽  
Lingling Zhou ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Thyroid Carcinoma ◽  
Medullary Thyroid Carcinoma ◽  
Gold Standard ◽  
Diagnostic Value ◽  
Benign Lesions ◽  
Clinical Value ◽  
Medullary Thyroid ◽  
Significant Difference ◽  
Enhanced Computed Tomography

Purpose: To explore the clinical value of ultrasound in the diagnosis of medullary thyroid carcinoma by comparing with enhanced computed tomography. Methods: This retrospective study was performed on 62 patients with pathologically confirmed medullary thyroid carcinoma. All patients underwent ultrasound and enhanced computed tomography examinations before surgery. The findings of the pathologic examination of resected specimens were considered as gold standard and were compared with the results of these 2 methods. Results: There were 73 medullary thyroid carcinoma lesions and 29 benign lesions in 62 patients. In all, 55 of 73 medullary thyroid carcinoma lesions and 27 of 29 benign lesions were correctly diagnosed by ultrasound; and 45 of 73 medullary thyroid carcinoma lesions and 24 of 29 benign lesions were correctly diagnosed by enhanced computed tomography. The accuracy of ultrasound and enhanced computed tomography was 80.4% and 67.6%, respectively. There was significant difference between 2 methods ( P < .05). Conclusions: Ultrasound can be used to observe the location, number, size, shape, border, internal echo, calcification, and blood flow of the lesion. It is a convenient, inexpensive, and nonradiative method with higher accuracy than enhanced computed tomography.

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