The role of protein kinase C and novel phorbol ester receptors in tumor cell invasion and metastasis (Review).

1999 ◽  
Author(s):  
D E Gomez ◽  
G Skilton ◽  
D F Alonso ◽  
M G Kazanietz
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Tumor Cell ◽  
Phorbol Ester ◽  
Cell Invasion ◽  
Tumor Cell Invasion ◽  
Invasion And Metastasis ◽  
Kinase C

The protein kinase C inhibitor, H7, inhibits tumor cell invasion and metastasis in mouse melanoma via suppression of ERK1/2

2007 ◽  
Vol 24 (6) ◽  
pp. 431-438 ◽  
Author(s):  
Masanobu Tsubaki ◽  
Hiroshi Matsuoka ◽  
Chikako Yamamoto ◽  
Chisato Kato ◽  
Mitsuhiko Ogaki ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Tumor Cell ◽  
Cell Invasion ◽  
Tumor Cell Invasion ◽  
Invasion And Metastasis ◽  
Mouse Melanoma ◽  
Kinase C ◽  
Protein Kinase C Inhibitor

Possible role of Na+ influx in phorbol ester-induced down-regulation of protein kinase C in HL60 cells

FEBS Letters ◽  
1993 ◽  
Vol 328 (3) ◽  
pp. 280-284 ◽  
Author(s):  
Noriko Takeuchi ◽  
Eikichi Hashimoto ◽  
Toru Nakamura ◽  
Fumito Takeuchi ◽  
Kiyonao Sada ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Phorbol Ester ◽  
Down Regulation ◽  
Hl60 Cells ◽  
Kinase C

2-Chloroadenosine prevents phorbol ester-induced depletion of protein kinase C in porcine coronary artery

1993 ◽  
Vol 264 (5) ◽  
pp. H1465-H1471 ◽  
Author(s):  
R. B. Marala ◽  
K. Ways ◽  
S. J. Mustafa
Keyword(s):  
Protein Kinase C ◽  
Coronary Artery ◽  
Protein Kinase ◽  
Phorbol Ester ◽  
Chronic Exposure ◽  
Porcine Coronary Artery ◽  
Kinase C ◽  
Adenosine Analogue ◽  
Presence And Absence

In this study we investigated the role of the adenosine analogue 2-chloroadenosine (CAD) in the regulation of protein kinase C (PKC) in porcine coronary artery. Arterial rings were contracted with endothelin-1 (ET-1; 10(-10) to 10(-7) M) and phorbol 12,13-dibutyrate (PDBu; 10(-7) M) after incubating them for 1 and 2 days with PDBu (200 nM) in the presence and absence of CAD (10(-4) M). Chronic exposure to PDBu alone attenuated ET-1-induced contractions, while inclusion of CAD during incubation protected against the PDBu-induced blunting of ET-1-induced contraction. Similarly, PDBu (10(-7) M)-induced contraction of the arterial rings was attenuated upon chronic incubation with PDBu, and once again, inclusion of CAD showed an improved response to PDBu-induced contraction when compared with PDBu alone. Incubation with PDBu (200 nM) for 20 min caused the PKC translocation from cytosol to membrane, whereas CAD totally blocked this translocation. Chronic (1 and 2 days) incubation with PDBu caused a substantial depletion of PKC activities in cytosol and membrane. The presence of CAD protected the PDBu-induced depletion of PKC in both cytosol and membrane. To replete PKC, after incubation with the drugs, the arteries were incubated in the absence of drugs for another 2 days. Arteries incubated with PDBu in the presence and absence of CAD recovered significantly in their response to ET-1 as well as PDBu. These results indicate that CAD protects against the PDBu-induced activation and depletion of PKC in porcine coronary artery.

Role of protein kinase C during interferon-γ- and phorbol ester-stimulated immunocytochemical expression of ICAM-1 in human renal carcinoma cells

Apmis ◽  
1993 ◽  
Vol 101 (1-6) ◽  
pp. 437-448 ◽  
Author(s):  
ALASTAIR B. HANSEN ◽  
PIERRE N. BOUCHELOUCHE ◽  
BIRGITTE N. GIESE ◽  
CLAUS B. ANDERSEN
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Phorbol Ester ◽  
Renal Carcinoma ◽  
Interferon Γ ◽  
Carcinoma Cells ◽  
Kinase C ◽  
Human Renal Carcinoma ◽  
Renal Carcinoma Cells

The Role of Pharmacological Ascorbate on Tumor Cell Invasion and Metastasis

2015 ◽  
Vol 87 ◽  
pp. S65-S66
Author(s):  
Juan Du ◽  
John A. Cieslak ◽  
Justin G. Wilkes ◽  
Garry R. Buettner ◽  
Joseph J. Cullen
Keyword(s):  
Tumor Cell ◽  
Cell Invasion ◽  
Tumor Cell Invasion ◽  
Invasion And Metastasis

Role of protein kinase C in the regulation of electrical and contractile activity of smooth muscle: Effect of phorbol ester

1987 ◽  
Vol 104 (1) ◽  
pp. 879-882
Author(s):  
M. B. Baskakov ◽  
V. B. Studnitskii ◽  
M. A. Medvedev ◽  
B. I. Khodorov
Keyword(s):  
Smooth Muscle ◽  
Protein Kinase C ◽  
Protein Kinase ◽  
Phorbol Ester ◽  
Contractile Activity ◽  
Kinase C
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