Polymorphic CAG repeat length within the androgen receptor gene: identification of a subgroup of patients with increased risk of ovarian cancer

2002 ◽  
Author(s):  
Manuela Santarosa ◽  
Ettore Bidoli ◽  
Angelo Gallo ◽  
Agostino Steffan ◽  
Mauro Boiocchi ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Androgen Receptor ◽  
Receptor Gene ◽  
Androgen Receptor Gene ◽  
Repeat Length ◽  
Cag Repeat ◽  
Gene Identification ◽  
Increased Risk

scholarly journals Androgen Receptor Gene Methylation and Exon One CAG Repeat Length in Ovarian Cancer: Differences from Breast Cancer

IUBMB Life ◽  
2004 ◽  
Vol 56 (7) ◽  
pp. 417-426 ◽  
Author(s):  
Samar Kassim ◽  
Nivan Zoheiry ◽  
Wael Hamed ◽  
James Going ◽  
John Craft
Keyword(s):  
Breast Cancer ◽  
Ovarian Cancer ◽  
Androgen Receptor ◽  
Receptor Gene ◽  
Androgen Receptor Gene ◽  
Repeat Length ◽  
Cag Repeat ◽  
Gene Methylation

scholarly journals South Indian men with reduced CAG repeat length in the androgen receptor gene have an increased risk of prostate cancer

2006 ◽  
Vol 51 (3) ◽  
pp. 254-257 ◽  
Author(s):  
Vijayalakshmi Krishnaswamy ◽  
Thangaraj Kumarasamy ◽  
Vettriselvi Venkatesan ◽  
Sunil Shroff ◽  
Vikram R. Jayanth ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Receptor Gene ◽  
Androgen Receptor Gene ◽  
Repeat Length ◽  
Cag Repeat ◽  
South Indian ◽  
Increased Risk ◽  
Indian Men

CAG repeat length in androgen-receptor gene and reproductive variables in fertile and infertile men

The Lancet ◽  
2002 ◽  
Vol 359 (9300) ◽  
pp. 44-46 ◽  
Author(s):  
Ewa Rajpert-De Meyts ◽  
Henrik Leffers ◽  
Jørgen H Petersen ◽  
Anne-Grethe Andersen ◽  
Elisabeth Carlsen ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Receptor Gene ◽  
Androgen Receptor Gene ◽  
Repeat Length ◽  
Cag Repeat ◽  
Infertile Men

scholarly journals Longer CAG repeat length in the androgen receptor gene is associated with premature ovarian failure

2009 ◽  
Vol 24 (12) ◽  
pp. 3230-3235 ◽  
Author(s):  
S. Chatterjee ◽  
R. Singh ◽  
S. Kadam ◽  
A. Maitra ◽  
K. Thangaraj ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Premature Ovarian Failure ◽  
Receptor Gene ◽  
Androgen Receptor Gene ◽  
Ovarian Failure ◽  
Repeat Length ◽  
Cag Repeat

scholarly journals Cag Repeat Number in the Androgen Receptor Gene and Prostate Cancer

2012 ◽  
Vol 15 (1) ◽  
pp. 31-36 ◽  
Author(s):  
S Madjunkova ◽  
A Eftimov ◽  
V Georgiev ◽  
D Petrovski ◽  
A Dimovski ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Cancer Risk ◽  
Receptor Gene ◽  
Prostate Cancer Risk ◽  
Androgen Receptor Gene ◽  
Repeat Length ◽  
Cag Repeat ◽  
Cag Repeats ◽  
Repeat Number

Cag Repeat Number in the Androgen Receptor Gene and Prostate CancerProstate cancer (PC) is the second leading cause of cancer deaths in men. The effects of androgens on prostatic tissue are mediated by the androgen receptor (AR) gene. The 5' end of exon 1 of the AR gene includes a polymorphic CAG triplet repeat that numbers between 10 to 36 in the normal population. The length of the CAG repeats is inversely related to the transactivation function of the AR gene. There is controversy over association between short CAG repeat numbers in the AR gene and PC. This retrospective case-control study evaluates the possible effect of short CAG repeats on the AR gene in prostate cancer risk in Macedonian males. A total of 392 male subjects, 134 PC patients, 106 patients with benign prostatic hyperplasia (BPH) and 152 males from the general Macedonian population were enrolled in this study. The CAG repeat length was determined by fluorescent polymerase chain reaction (PCR) amplification of exon1 of the AR gene followed by capillary electrophoresis (CE) on a genetic analyzer. The mean repeat length in PC patients was 21.5 ±2.65, in controls 22.28 ±2.86 (p = 0.009) and in BPH patients 22.1 ±2.52 (p = 0.038). Short CAG repeats (<19) were found in 21.64% of PC patients vs. 9.43% in BPH patients (p = 0.0154). We also found an association of low Gleason score (<7) with short CAG repeat (<19) in PC patients (p = 0.0306), and no association between the age at diagnosis of PC and BPH and CAG repeat length. These results suggest that reduced CAG repeat length may be associated with increased prostate cancer risk in Macedonian men.

scholarly journals Male Infertility and Variation in CAG Repeat Length in the Androgen Receptor Gene: A Meta-analysis

2007 ◽  
Vol 92 (11) ◽  
pp. 4319-4326 ◽  
Author(s):  
Carol A. Davis-Dao ◽  
Ellenie D. Tuazon ◽  
Rebecca Z. Sokol ◽  
Victoria K. Cortessis
Keyword(s):  
Androgen Receptor ◽  
Male Infertility ◽  
Meta Analysis ◽  
Receptor Gene ◽  
Androgen Receptor Gene ◽  
Repeat Length ◽  
Cag Repeat

Is reduced CAG repeat length in androgen receptor gene associated with risk of prostate cancer in Indian population?

2005 ◽  
Vol 68 (1) ◽  
pp. 55-60 ◽  
Author(s):  
DK Mishra ◽  
K Thangaraj ◽  
A Mandhani ◽  
A Kumar ◽  
RD Mittal
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Indian Population ◽  
Receptor Gene ◽  
Androgen Receptor Gene ◽  
Repeat Length ◽  
Cag Repeat

scholarly journals Contributions of CAG repeat length in the androgen receptor gene and androgen profiles to premature pubarche in Korean girls

2017 ◽  
Vol 64 (1) ◽  
pp. 91-102 ◽  
Author(s):  
Min Jae Kang ◽  
Jeong Seon Lee ◽  
Hwa Young Kim ◽  
Hae Woon Jung ◽  
Young Ah Lee ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Receptor Gene ◽  
Androgen Receptor Gene ◽  
Repeat Length ◽  
Cag Repeat ◽  
Premature Pubarche

Polymorphic CAG repeat length in the androgen receptor gene and association with neurodegeneration in a heterozygous female carrier of Kennedy?s disease

2004 ◽  
Vol 251 (1) ◽  
pp. 35-41 ◽  
Author(s):  
Karen J. Greenland ◽  
Jonathan Beilin ◽  
Julian Castro ◽  
Paul N. Varghese ◽  
Jeffrey D. Zajac
Keyword(s):  
Androgen Receptor ◽  
Receptor Gene ◽  
Androgen Receptor Gene ◽  
Repeat Length ◽  
Cag Repeat ◽  
Female Carrier ◽  
Heterozygous Female

CAG repeat length in androgen receptor gene and male infertility in Egyptian patients

Andrologia ◽  
2011 ◽  
Vol 44 (1) ◽  
pp. 26-33 ◽  
Author(s):  
Y. M. Mosaad ◽  
D. Shahin ◽  
A. A-M. Elkholy ◽  
A. Mosbah ◽  
W. Badawy
Keyword(s):  
Androgen Receptor ◽  
Male Infertility ◽  
Receptor Gene ◽  
Androgen Receptor Gene ◽  
Repeat Length ◽  
Cag Repeat ◽  
Egyptian Patients
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