Development and Validation of Dissolution Study of Sustained Release Dextromethorphan Hydrobromide Tablets

2014 ◽  
Vol 17 (3) ◽  
pp. 429-433
Author(s):  
Sekar Rajan ◽  
Socorrina Colaco ◽  
N. Ramesh ◽  
Subramania Nainar Meyyanatha ◽  
K. Elango
Keyword(s):  
Sustained Release ◽  
Dissolution Study ◽  
Development And Validation ◽  
Dextromethorphan Hydrobromide

DEVELOPMENT AND VALIDATION OF HIGH PERFORMANCE LIQUID CHROMATOGRAPHY METHOD FOR SIMULTANEOUS ESTIMATION OF DEXTROMETHORPHAN HYDROBROMIDE AND QUINIDINE SULPHATE IN PHARMACEUTICAL DOSAGE FORM

INDIAN DRUGS ◽  
2017 ◽  
Vol 54 (01) ◽  
pp. 35-40
Author(s):  
A. S. Bagde ◽  
V. V. Khanvilkar ◽  
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
High Performance ◽  
Hplc Method ◽  
Simultaneous Estimation ◽  
Chromatography Method ◽  
Pharmaceutical Dosage Form ◽  
Liquid Chromatography Method ◽  
Development And Validation ◽  
Dextromethorphan Hydrobromide

The present work describes a validated reverse phase high performance liquid chromatography (RPHPLC) method for simultaneous estimation of dextromethorphan hydrobromide and quinidine sulphate in pharmaceutical dosage from. The drugs were resolved using Hemochrom Intsil C18-5U column (250×4.6) mm in isocratic mode with mobile phase methanol: water (0.08% diethylamine, 0.02% of glacial acetic acid and pH 4.4 adjusted with orthophosphoric acid) in the ratio of 70:30 V/V at a flow rate of 1.0 mL/min. Retention time of dextromethorphan hydrobromide and quinidine sulphate were 4.9±0.2 and 3.6±0.2, respectively, at 292nm. The above mentioned method was validated as per International Conference on Harmonization (ICH) guidelines. Linear responses were obtained in concentration ranges of 5-35 μg/mL for dextromethorphan hydrobromide and 4-16 μg/mL for quinidine sulphate, with correlation coefficient (r2) of 0.999 for both the drugs. A simple, selective, accurate, precise, robust and reliable RP-HPLC method thus developed and validated for simultaneous estimation of dextromethorphan hydrobromide and quinidine sulphate.

Oral sustained release nystatin tablets for the treatment of oral candidiasis: formulation development and validation of UV spectrophotometric analytical methodology for content determination

2009 ◽  
Vol 36 (5) ◽  
pp. 594-600 ◽  
Author(s):  
Michelle Maria Gonçalves Barão de Aguiar ◽  
Raphael Pereira de Albuquerque ◽  
Daniel Savignon Marinho ◽  
Bárbara Regina Souza Braga ◽  
Camila Braga Dornelas ◽  
...  
Keyword(s):  
Sustained Release ◽  
Oral Candidiasis ◽  
Formulation Development ◽  
Analytical Methodology ◽  
Content Determination ◽  
Development And Validation

scholarly journals DEVELOPMENT AND VALIDATION OF DOUBLE DIVISOR RATIO SPECTRA DERIVATIVE SPECTROPHOTOMETRY METHOD FOR TERNARY MIXTURE OF DEXTROMETHORPHAN HYDROBROMIDE, DOXYLAMINE SUCCINATE AND PSEUDOEPHEDRINE HYDROCHLORIDE IN TABLET DOSAGE FORM

2020 ◽  
pp. 249-252
Author(s):  
RIDA EVALINA TARIGAN ◽  
MUCHLISYAM ◽  
SITI MORIN SINAGA ◽  
ZUL ALFIAN
Keyword(s):  
Ternary Mixture ◽  
Dosage Form ◽  
Acceptable Range ◽  
Validation Parameters ◽  
Recovery Study ◽  
The Mean ◽  
Development And Validation ◽  
Tablet Dosage ◽  
Dextromethorphan Hydrobromide

This study aimed to develop spectrophotometry method by double divisor ratio spectra derivative to determine the levels of dextromethorphan hydrobromide (DEX), doxylamine succinate (DOX) and pseudoephedrine hydrochloride (PSE) in tablet dosage form using ethanol as solvent. The method is based on the use of the coincident spectra of the derivative of the ratio spectra obtained using a double divisor and measuring at the wavelengths selected. Then, the method was applied to determine the levels of DEX, DOX and PSE in tablet dosage form. The selected wavelengths for determination of DEX, DOX and PSE are 277.0 nm, 243.0 nm, and 243.2 nm, respectively. The mean % recoveries were found to be in 100.88%, 100.05%, and 100.26% for DEX, DOX and PSE, respectively. The method is successfully applied to analyze DEX, DOX and PSE in pharmaceutical formulation with no interference from excipients as indicated by the recovery study. All validation parameters were within the acceptable range.

Formulation and Evaluation of Dextromethorphan Hydrobromide Sustained Release Tablets

Drug Delivery ◽  
2008 ◽  
Vol 15 (7) ◽  
pp. 429-435 ◽  
Author(s):  
Subramania Nainar Meyyanathan ◽  
Sekar Rajan ◽  
Selvadurai Muralidaharan ◽  
Mahesh Kumar Siddaiah ◽  
Kaliaperumal Krishnaraj ◽  
...  
Keyword(s):  
Sustained Release ◽  
Sustained Release Tablets ◽  
Dextromethorphan Hydrobromide
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