scholarly journals THE EFFECT OF LOW MOLECULAR WEIGHT DEXTRAN ON BLOOD COAGULATION IN OPEN HEART SURGERY USING EXTRACORPOREAL CIRCULATION, WITH SPECIAL REFERENCE TO THROMBELASTOGRAPHIC FINDINGS

1966 ◽  
Vol 13 (4) ◽  
pp. 97-111
Author(s):  
Takashi MIYAMOTO
Keyword(s):  
Molecular Weight ◽  
Special Reference ◽  
Blood Coagulation ◽  
Extracorporeal Circulation ◽  
Heart Surgery ◽  
Open Heart Surgery ◽  
Low Molecular Weight ◽  
Open Heart

Blood Coagulation Studies and Extracorporeal Circulation in Man

1967 ◽  
Vol 18 (03/04) ◽  
pp. 634-646 ◽  
Author(s):  
N Thurnherr
Keyword(s):  
Blood Coagulation ◽  
Extracorporeal Circulation ◽  
Blood Clotting ◽  
Heart Surgery ◽  
Open Heart Surgery ◽  
Fibrinolytic System ◽  
Open Heart ◽  
Clotting Factors ◽  
Blood Clotting Factors

SummaryBlood clotting investigations have been executed in 25 patients who have undergone open heart surgery with extracorporeal circulation. A description of alterations in the activity of blood clotting factors, the fibrinolytic system, prothrombin consumption and platelets during several phases of the operation is given.

BLOOD-LOSS IN OPEN-HEART SURGERY WITH LOW-MOLECULAR-WEIGHT DEXTRAN

The Lancet ◽  
1963 ◽  
Vol 281 (7292) ◽  
pp. 1190-1191 ◽  
Author(s):  
I.M. Breckenridge ◽  
W.F. Walker
Keyword(s):  
Molecular Weight ◽  
Blood Loss ◽  
Heart Surgery ◽  
Open Heart Surgery ◽  
Low Molecular Weight ◽  
Open Heart

The Hemostatic Mechanism after Open-Heart Surgery

1978 ◽  
Vol 39 (02) ◽  
pp. 474-487 ◽  
Author(s):  
E R Cole ◽  
F Bachmann ◽  
C A Curry ◽  
D Roby
Keyword(s):  
Extracorporeal Circulation ◽  
Heart Surgery ◽  
Polyacrylamide Gel Electrophoresis ◽  
Open Heart Surgery ◽  
Coagulation System ◽  
Open Heart ◽  
Time Activity ◽  
Post Surgery ◽  
Plasma Fractions ◽  
The Mean

SummaryA prospective study in 13 patients undergoing open-heart surgery with extracorporeal circulation revealed a marked decrease of the mean one-stage prothrombin time activity from 88% to 54% (p <0.005) but lesser decreases of factors I, II, V, VII and X. This apparent discrepancy was due to the appearance of an inhibitor of the extrinsic coagulation system, termed PEC (Protein after Extracorporeal Circulation). The mean plasma PEC level rose from 0.05 U/ml pre-surgery to 0.65 U/ml post-surgery (p <0.0005), and was accompanied by the appearance of additional proteins as evidenced by disc polyacrylamide gel electrophoresis of plasma fractions (p <0.0005). The observed increases of PEC, appearance of abnormal protein bands and concomitant increases of LDH and SGOT suggest that the release of an inhibitor of the coagulation system (similar or identical to PIVKA) may be due to hypoxic liver damage during extracorporeal circulation.

Heparin Concentrations Correlated To The Activated Whole Blood Clotting Time (Act) During Extracorporeal Circulation

1981 ◽  
Author(s):  
S Stenbjerg ◽  
E Berg ◽  
O K Albrechtsen
Keyword(s):  
Extracorporeal Circulation ◽  
Whole Blood ◽  
Blood Clotting ◽  
Heart Surgery ◽  
Open Heart Surgery ◽  
Open Heart ◽  
Excellent Correlation ◽  
Clotting Time ◽  
Automated Method ◽  
Blood Clotting Time

Heparin levels and ACT were followed during open heart surgery in lo patients. Heparin was assayed by an amidolytic method using substrate S-2222. ACT was determined with an automated method using celite and glass beads as activators of coagulation. Neither the hemodilution nor the depletion of platelets observed during extracorporeal circulation seemed to influence the ACT. An excellent correlation between the ACT and the actual heparin level was found in each patient with coefficients of correlation ranging from 0.73 – 0.97. A slightly better correlation was noticed for values of ACT below 600 seconds. It was concluded that the ACT is a valuable and reliable tool in control of heparinisation during open heart surgery.

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