scholarly journals A free boundary problem of nonlinear diffusion equation with positive bistable nonlinearity in high space dimensions I : Classification of asymptotic behavior

2022 ◽  
Vol 0 (0) ◽  
pp. 0
Author(s):  
Yuki Kaneko ◽  
Hiroshi Matsuzawa ◽  
Yoshio Yamada

<p style='text-indent:20px;'>We study a free boundary problem of a reaction-diffusion equation <inline-formula><tex-math id="M1">\begin{document}$ u_t = \Delta u+f(u) $\end{document}</tex-math></inline-formula> for <inline-formula><tex-math id="M2">\begin{document}$ t&gt;0,\ |x|&lt;h(t) $\end{document}</tex-math></inline-formula> under a radially symmetric environment in <inline-formula><tex-math id="M3">\begin{document}$ \mathbb{R}^N $\end{document}</tex-math></inline-formula>. The reaction term <inline-formula><tex-math id="M4">\begin{document}$ f $\end{document}</tex-math></inline-formula> has positive bistable nonlinearity, which satisfies <inline-formula><tex-math id="M5">\begin{document}$ f(0) = 0 $\end{document}</tex-math></inline-formula> and allows two positive stable equilibrium states and a positive unstable equilibrium state. The problem models the spread of a biological species, where the free boundary represents the spreading front and is governed by a one-phase Stefan condition. We show multiple spreading phenomena in high space dimensions. More precisely the asymptotic behaviors of solutions are classified into four cases: big spreading, small spreading, transition and vanishing, and sufficient conditions for each dynamical behavior are also given. We determine the spreading speed of the spherical surface <inline-formula><tex-math id="M6">\begin{document}$ \{x\in \mathbb{R}^N:\ |x| = h(t)\} $\end{document}</tex-math></inline-formula>, which expands to infinity as <inline-formula><tex-math id="M7">\begin{document}$ t\to\infty $\end{document}</tex-math></inline-formula>, even when the corresponding semi-wave problem does not admit solutions.</p>

2018 ◽  
Vol 11 (01) ◽  
pp. 1850008
Author(s):  
Shihe Xu ◽  
Meng Bai ◽  
Zhong Wang ◽  
Fangwei Zhang

In this paper, a free boundary problem for a solid avascular tumor growth under the action of periodic external inhibitors with time delays in proliferation is studied. Sufficient conditions for the global stability of tumor-free equilibrium are given. Moreover, if external concentration of nutrients is large, we also prove that the tumor will not disappear and determine the conditions under which there exist periodic solutions to the model. The results show that the periodicity of the inhibitor may imply periodicity of the size of the tumor. More precisely, if [Formula: see text] (the concentration of external nutrients) is greater than [Formula: see text], where [Formula: see text] are two constants; [Formula: see text]; [Formula: see text] is a periodic function which can be interpreted as a treatment and [Formula: see text] is the period of [Formula: see text]. Results are illustrated by computer simulations.


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