<p style='text-indent:20px;'>We study a free boundary problem of a reaction-diffusion equation <inline-formula><tex-math id="M1">\begin{document}$ u_t = \Delta u+f(u) $\end{document}</tex-math></inline-formula> for <inline-formula><tex-math id="M2">\begin{document}$ t>0,\ |x|<h(t) $\end{document}</tex-math></inline-formula> under a radially symmetric environment in <inline-formula><tex-math id="M3">\begin{document}$ \mathbb{R}^N $\end{document}</tex-math></inline-formula>. The reaction term <inline-formula><tex-math id="M4">\begin{document}$ f $\end{document}</tex-math></inline-formula> has positive bistable nonlinearity, which satisfies <inline-formula><tex-math id="M5">\begin{document}$ f(0) = 0 $\end{document}</tex-math></inline-formula> and allows two positive stable equilibrium states and a positive unstable equilibrium state. The problem models the spread of a biological species, where the free boundary represents the spreading front and is governed by a one-phase Stefan condition. We show multiple spreading phenomena in high space dimensions. More precisely the asymptotic behaviors of solutions are classified into four cases: big spreading, small spreading, transition and vanishing, and sufficient conditions for each dynamical behavior are also given. We determine the spreading speed of the spherical surface <inline-formula><tex-math id="M6">\begin{document}$ \{x\in \mathbb{R}^N:\ |x| = h(t)\} $\end{document}</tex-math></inline-formula>, which expands to infinity as <inline-formula><tex-math id="M7">\begin{document}$ t\to\infty $\end{document}</tex-math></inline-formula>, even when the corresponding semi-wave problem does not admit solutions.</p>