scholarly journals Assessing the association between the methylenetetrahydrofolate reductase (MTHFR) 677C>T polymorphism and blood folate concentrations: a systematic review and meta-analysis of trials and observational studies

2015 ◽  
Vol 101 (6) ◽  
pp. 1286-1294 ◽  
Author(s):  
Becky L Tsang ◽  
Owen J Devine ◽  
Amy M Cordero ◽  
Claire M Marchetta ◽  
Joseph Mulinare ◽  
...  
Keyword(s):  
Systematic Review ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Observational Studies ◽  
Methylenetetrahydrofolate Reductase ◽  
Meta Analysis ◽  
Mthfr C677t ◽  
Assessment Method ◽  
Percentage Difference ◽  
Lower Blood

ABSTRACTBackground: The methylenetetrahydrofolate reductase (MTHFR) 677C>T polymorphism is a risk factor for neural tube defects. The T allele produces an enzyme with reduced folate-processing capacity, which has been associated with lower blood folate concentrations.Objective: We assessed the association between MTHFR C677T genotypes and blood folate concentrations among healthy women aged 12–49 y.Design: We conducted a systematic review of the literature published from January 1992 to March 2014 to identify trials and observational studies that reported serum, plasma, or red blood cell (RBC) folate concentrations and MTHFR C677T genotype. We conducted a meta-analysis for estimates of percentage differences in blood folate concentrations between genotypes.Results: Forty studies met the inclusion criteria. Of the 6 studies that used the microbiologic assay (MA) to measure serum or plasma (S/P) and RBC folate concentrations, the percentage difference between genotypes showed a clear pattern of CC > CT > TT. The percentage difference was greatest for CC > TT [S/P: 13%; 95% credible interval (CrI): 7%, 18%; RBC: 16%; 95% CrI: 12%, 20%] followed by CC > CT (S/P: 7%; 95% CrI: 1%, 12%; RBC: 8%; 95% CrI: 4%, 12%) and CT > TT (S/P: 6%; 95% CrI: 1%, 11%; RBC: 9%; 95% CrI: 5%, 13%). S/P folate concentrations measured by using protein-binding assays (PBAs) also showed this pattern but to a greater extent (e.g., CC > TT: 20%; 95% CrI: 17%, 22%). In contrast, RBC folate concentrations measured by using PBAs did not show the same pattern and are presented in the Supplemental Material only.Conclusions: Meta-analysis results (limited to the MA, the recommended population assessment method) indicated a consistent percentage difference in S/P and RBC folate concentrations across MTHFR C677T genotypes. Lower blood folate concentrations associated with this polymorphism could have implications for a population-level risk of neural tube defects.

scholarly journals Assessing the Association between the Methylenetetrahydrofolate Reductase (MTHFR) 677C->T Polymorphism on Blood Folate Concentrations: A Systematic Review and Meta-analysis of Trials and Observational Studies

2015 ◽  
pp. 650-651
Author(s):  
Becky Tsang ◽  
Amy Cordero ◽  
Claire Marchetta ◽  
Joseph Mulinare ◽  
Patricia Mersereau ◽  
...  
Keyword(s):  
Systematic Review ◽  
Protein Binding ◽  
Observational Studies ◽  
Methylenetetrahydrofolate Reductase ◽  
Meta Analysis ◽  
Mthfr C677t ◽  
Review Of Literature ◽  
Binding Assays ◽  
Lower Blood ◽  
Meta Analyses

Objectives: The methylenetetrahydrofolate reductase (MTHFR) 677C->T polymorphism is a risk factor for neural tube birth defects (NTDs). The T allele produces an enzyme with reduced folate processing capacity, which has been shown to produce lower blood folate concentrations in some studies. Our objective was to assess the association between MTHFR C677T genotypes (CC, CT, TT) and blood folate concentrations among women aged 12-49 years. Methods: We conducted a systematic review of literature published between 1/1992-7/2013 to identify controlled trials and observational studies that reported serum, plasma, or red blood cell (RBC) folate concentrations and MTHFR C677T genotype. We applied a Bayesian random-effects model to predict differences in blood folate concentrations between MTHFR C677T genotypes, stratified by folate assay. Results: Thirty-eight studies met criteria for inclusion. Serum/plasma folate concentrations showed a consistent genotype trend with the highest concentrations for CC (CC > CT > TT) regardless of assay type. RBC folate concentrations measured by microbiologic assay also demonstrated this trend; however, this trend was reversed (CC < CT < TT) in studies using protein-binding assays. Conclusions: Meta-analyses results showed blood folate concentrations differed by assay type and genotype. Previous evidence has shown that RBC folate concentrations measured with a radioimmunoassay requires adjustment for genotype-dependent folate recovery; our results suggest that other protein-binding assays could have similar limitations. Compared to CC individuals, TT individuals have lower blood folate concentrations, which may increase a woman's risk for an NTD-affected pregnancy.

Association of Fetal MTHFR C677T Polymorphism with Susceptibility to Neural Tube Defects: A Systematic Review and Update Meta-Analysis

2020 ◽  
pp. 1-17
Author(s):  
Razieh Sadat Tabatabaei ◽  
Neda Fatahi-Meibodi ◽  
Bahare Meibodi ◽  
Atiyeh Javaheri ◽  
Hajar Abbasi ◽  
...  
Keyword(s):  
Systematic Review ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Meta Analysis ◽  
Mthfr C677t ◽  
C677t Polymorphism ◽  
Mthfr C677t Polymorphism

Clomiphene citrate and neural tube defects: A meta-analysis of controlled observational studies

2018 ◽  
Vol 80 ◽  
pp. 157-158
Author(s):  
Marine Auffret ◽  
Judith Cottin ◽  
Aurore Gouraud ◽  
Michel Cucherat
Keyword(s):  
Neural Tube ◽  
Neural Tube Defects ◽  
Observational Studies ◽  
Meta Analysis ◽  
Clomiphene Citrate

Maternal, paternal, and neonatal risk factors for neural tube defects: A systematic review and meta‐analysis

2019 ◽  
Vol 78 (1) ◽  
pp. 227-235 ◽  
Author(s):  
Shanshan Jia ◽  
Xiaowei Wei ◽  
Ling Ma ◽  
Yanfu Wang ◽  
Hui Gu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Meta Analysis ◽  
Neonatal Risk Factors

scholarly journals Neighborhood Deprivation and Risk of Congenital Heart Defects, Neural Tube Defects and Orofacial Clefts: A Systematic Review and Meta-Analysis

PLoS ONE ◽  
2016 ◽  
Vol 11 (10) ◽  
pp. e0159039 ◽  
Author(s):  
Séverine Deguen ◽  
Wahida Kihal ◽  
Maxime Jeanjean ◽  
Cindy Padilla ◽  
Denis Zmirou-Navier
Keyword(s):  
Systematic Review ◽  
Congenital Heart Defects ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Congenital Heart ◽  
Heart Defects ◽  
Meta Analysis ◽  
Orofacial Clefts ◽  
Neighborhood Deprivation

Association between Fetal MTHFR A1298C (rs1801131) Polymorphism and Neural Tube Defects Risk: A Systematic Review and Meta-Analysis

2020 ◽  
pp. 1-18
Author(s):  
Sara Soleimani-Jadidi ◽  
Bahare Meibodi ◽  
Atiyeh Javaheri ◽  
Razieh Sadat Tabatabaei ◽  
Amaneh Hadadan ◽  
...  
Keyword(s):  
Systematic Review ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Meta Analysis ◽  
Mthfr A1298c

scholarly journals Birth prevalence of neural tube defects and associated risk factors in Africa: a systematic review and meta-analysis

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Mohammed Oumer ◽  
Ashenafi Tazebew ◽  
Mezgebu Silamsaw
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Test Statistic ◽  
Birth Prevalence ◽  
Effect Model ◽  
Associated Risk Factors

Abstract Background Neural tube defects are common congenital anomalies that result from early malformation in the development of the spinal cord and brain. It is related to substantial mortality, morbidity, disability, and psychological and economic costs. The aim of this review is to determine the pooled birth prevalence of neural tube defects and associated risk factors in Africa. Methods The first outcome of this review was the pooled birth prevalence of the neural tube defects and the second outcome was the pooled measure of association between neural tube defects and associated risk factors in Africa. We systematically searched PubMed, PubMed Central, Joanna Briggs Institute, Google Scopus, Cochrane Library, African Journals Online, Web of Science, Science Direct, Google Scholar, and Medline databases. The heterogeneity of studies was assessed using the Cochrane Q test statistic, I2 test statistic, and, visually, using Forest and Galbraith’s plots. A random-effect model was applied to get the pooled birth prevalence of neural tube defects. Subgroup, sensitivity, meta-regression, time-trend, and meta-cumulative analyses were undertaken. The fixed-effect model was used to analyze the association between neural tube defects and associated risk factors. Results Forty-three studies with a total of 6086,384 participants were included in this systematic review and meta-analysis. The pooled birth prevalence of the neural tube defects was 21.42 (95% CI (Confidence Interval): 19.29, 23.56) per 10,000 births. A high pooled birth prevalence of neural tube defects was detected in Algeria 75 (95% CI: 64.98, 85.02), Ethiopia 61.43 (95% CI: 46.70, 76.16), Eritrea 39 (95% CI: 32.88, 45.12), and Nigeria 32.77 (95% CI: 21.94, 43.59) per 10,000 births. The prevalence of neural tube defects has increased over time. Taking folic acid during early pregnancy, consanguineous marriage, male sex, and substance abuse during pregnancy were assessed and none of them was significant. Conclusions The pooled birth prevalence of neural tube defects in Africa was found to be high. The risk factors evaluated were not found significant.

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