scholarly journals Effect of .ALPHA..BETA.-Blocker Carvedilol on whole-body and hepatic hemodynamics in liver cirrhosis.

1997 ◽  
Vol 28 (1) ◽  
pp. 203-204
Author(s):  
TATSUYA SEKIYAMA
Keyword(s):  
Liver Cirrhosis ◽  
Beta Blocker ◽  
Whole Body ◽  
Hepatic Hemodynamics ◽  
Alpha Beta

Impairment of albumin and whole body postprandial protein synthesis in compensated liver cirrhosis

2002 ◽  
Vol 282 (2) ◽  
pp. E304-E311 ◽  
Author(s):  
P. Tessari ◽  
R. Barazzoni ◽  
E. Kiwanuka ◽  
G. Davanzo ◽  
G. De Pergola ◽  
...  
Keyword(s):  
Protein Synthesis ◽  
Liver Cirrhosis ◽  
Disease Stage ◽  
Whole Body ◽  
Synthesis Rate ◽  
Albumin Concentration ◽  
Mixed Meal ◽  
Body Protein ◽  
Control Subjects ◽  
Class B

To investigate the anabolic effects of feeding in cirrhosis, we measured albumin fractional synthesis rate (FSR) and whole body protein synthesis in six nondiabetic patients with stable liver cirrhosis (three in the Child-Pugh classification Class A, three in Class B) and in seven normal control subjects, before and after administration of a 4-h mixed meal. Leucine tracer precursor-product relationships and whole body kinetics were employed at steady state. Basal levels of postabsorptive albumin concentration and FSR, whole body leucine rate of appearance, oxidation, and nonoxidative leucine disposal (NOLD, ≈protein synthesis) were similar in the two groups. However, after the meal, in the patients neither albumin FSR (from 8.5 ± 1.5 to 8.8 ± 1.8 %/day) nor NOLD (from 1.69 ± 0.22 to 1.55 ± 0.26 μmol · kg−1· min−1) changed ( P = nonsignificant vs. basal), whereas they increased in control subjects (albumin FSR: from 10.9 ± 1.5 to 15.9 ± 1.9 %/day, P < 0.002; NOLD: from 1.80 ± 0.14 to 2.10 ± 0.19 μmol · kg−1· min−1, P = 0.032). Thus mixed meal ingestion did not stimulate either albumin FSR or whole body protein synthesis in compensated liver cirrhosis. The mechanism(s) maintaining normoalbuminemia at this disease stage need to be further investigated.

Fasting and postprandial phenylalanine and leucine kinetics in liver cirrhosis

1994 ◽  
Vol 267 (1) ◽  
pp. E140-E149 ◽  
Author(s):  
P. Tessari ◽  
S. Inchiostro ◽  
R. Barazzoni ◽  
M. Zanetti ◽  
R. Orlando ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Protein Turnover ◽  
Normal Subjects ◽  
Whole Body ◽  
Protein Breakdown ◽  
Phenylalanine Concentration ◽  
Mixed Meal ◽  
Body Protein ◽  
Plasma Phenylalanine ◽  
Leucine Kinetics

To investigate body protein turnover and the pathogenesis of increased concentration of plasma phenylalanine in liver cirrhosis, we have studied phenylalanine and leucine kinetics in cirrhotic (diabetic and nondiabetic) patients, and in normal subjects, both in the postabsorptive state and during a mixed meal, using combined intravenous and oral isotope infusions. Postabsorptive phenylalanine concentration and whole body rate of appearance (Ra) were approximately 40% greater (P < 0.05) in patients than in controls. Leucine concentrations were comparable, but intracellular leucine Ra was also increased (P < 0.05), suggesting increased whole body protein breakdown. Postprandial phenylalanine Ra was also greater (P < 0.05) in the patients. This difference was due to a diminished fractional splanchnic uptake of the dietary phenylalanine (approximately 40% lower in the cirrhotics vs. controls, P < or = 0.05). Postprandial leucine Ra was also increased in the patients, but splanchnic uptake of dietary leucine was normal. Thus both increased body protein breakdown and decreased splanchnic extraction of dietary phenylalanine can account for the increased phenylalanine concentrations in liver cirrhosis.

Evaluation of one dimensional profile scans with a whole body counter -82bromide space in liver cirrhosis: Concise communication

1979 ◽  
Vol 4 (3) ◽  
pp. 231-234 ◽  
Author(s):  
Otmar Schober ◽  
Bernd Knoop ◽  
Peter Mari� ◽  
Kurt Jordan ◽  
Heinz Hundeshagen ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Whole Body ◽  
One Dimensional ◽  
Body Counter ◽  
Whole Body Counter

Whole body protein turnover in malnourished patients with alcoholic liver cirrhosis

1991 ◽  
Vol 13 ◽  
pp. S151
Author(s):  
K. Nielsen ◽  
J. Kondrup ◽  
B. Stilling ◽  
K. Nielsen ◽  
L. Martinsen ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Protein Turnover ◽  
Whole Body ◽  
Alcoholic Liver Cirrhosis ◽  
Body Protein

scholarly journals Structural and functional changes of abdominal organs in patients with hepatocerebral degeneration

2021 ◽  
Keyword(s):  
Liver Cirrhosis ◽  
Chronic Hepatitis ◽  
Endothelial Function ◽  
Abdominal Cavity ◽  
Ultrasound Elastography ◽  
Functional Changes ◽  
Normal Limits ◽  
Hepatocerebral Degeneration ◽  
Hepatic Hemodynamics ◽  
Food Load

The paper presents the results of ultrasound diagnostic of 76 patients with neurological forms of hepatocerebral degeneration (HCD) or Wilson’s disease (WD), who were examined and treated at the clinic of the Institute of Neurology, Psychiatry and Narcology of the National Academy of Medical Sciences of Ukraine. According to ultrasound diagnostic, all patients had pathological changes in the liver. In 58% of patients these changes corresponded to chronic hepatitis, in 42% - liver cirrhosis, and in 32% of patients were reported for portal hypertension. Background hepatic hemodynamics of patients was within normal limits, but in 82% of them the reaction to food load was negative. Doppler study showed that background hepatic hemodynamics in patients with neurological forms of hepatocerebral degeneration (GCD) was within normal limits. However, the food load showed that 82% of patients had impaired reciprocal autoregulation of liver microcirculation. This indicates a decrease in their compensatory-adaptive capacity of the liver. This position is confirmed by the fact that 70% of these patients have a decrease in vasoactive endothelial function. Our study of the functional state of the vascular endothelium showed that patients with GCD have a significant decrease in vasoactive endothelial function. In general, the group was only 8.12% at a rate of 10% or more. Despite the young average age of our patients (29.7 years), only 30% of patients had a normal vasoactive reaction. These were patients under the age of 25 from the group of chronic hepatitis. The degree of endothelial dysfunction was significantly higher in patients with liver cirrhosis compared with chronic hepatitis. According to ultrasound elastography, in the vast majority of examined patients with GCD (88%) there was increased stiffness of the liver parenchyma. On the average on group of patients it made 10,62 KPA with a range from 4,74 to 20,69 KPA (norm 0,4-6,0 KPA). Thus, patients with neurological forms of GCD, which are observed by a neurologist, it is necessary before each course of treatment, but at least 1-2 times a year, to conduct ultrasound of the abdominal cavity.

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