Genetic Algorithm to Solve Multi-Period, Multi-Product, Bi-Echelon Supply Chain Network Design Problem

2009 ◽  
Vol 2 (4) ◽  
pp. 24-42 ◽  
Author(s):  
R. Dhanalakshmi ◽  
P. Parthiban ◽  
K. Ganesh ◽  
T. Arunkumar
Keyword(s):  
Supply Chain ◽  
Supply Chains ◽  
Raw Materials ◽  
Optimization Techniques ◽  
Network Design Problem ◽  
Production Plant ◽  
Two Stage ◽  
Cost Structures ◽  
Multi Stage ◽  
Product Costs

In many multi-stage manufacturing supply chains, transportation related costs are a significant portion of final product costs. It is often crucial for successful decision making approaches in multi-stage manufacturing supply chains to explicitly account for non-linear transportation costs. In this article, we have explored this problem by considering a Two-Stage Production-Transportation (TSPT). A two-stage supply chain that faces a deterministic stream of external demands for a single product is considered. A finite supply of raw materials, and finite production at stage one has been assumed. Items are manufactured at stage one and transported to stage two, where the storage capacity of the warehouses is limited. Packaging is completed at stage two (that is, value is added to each item, but no new items are created), and the finished goods inventories are stored which is used to meet the final demand of customers. During each period, the optimized production levels in stage one, as well as transportation levels between stage one and stage two and routing structure from the production plant to warehouses and then to customers, must be determined. The authors consider “different cost structures,” for both manufacturing and transportation. This TSPT model with capacity constraint at both stages is optimized using Genetic Algorithms (GA) and the results obtained are compared with the results of other optimization techniques of complete enumeration, LINDO, and CPLEX.

Genetic Algorithm to Solve Multi-Period, Multi-Product, Bi-Echelon Supply Chain Network Design Problem

2011 ◽  
pp. 275-289
Author(s):  
R. Dhanalakshmi ◽  
P. Parthiban ◽  
K. Ganesh ◽  
T. Arunkumar
Keyword(s):  
Supply Chain ◽  
Supply Chains ◽  
Raw Materials ◽  
Optimization Techniques ◽  
Network Design Problem ◽  
Production Plant ◽  
Two Stage ◽  
Cost Structures ◽  
Multi Stage ◽  
Product Costs

In many multi-stage manufacturing supply chains, transportation related costs are a significant portion of final product costs. It is often crucial for successful decision making approaches in multi-stage manufacturing supply chains to explicitly account for non-linear transportation costs. In this article, we have explored this problem by considering a Two-Stage Production-Transportation (TSPT). A two-stage supply chain that faces a deterministic stream of external demands for a single product is considered. A finite supply of raw materials, and finite production at stage one has been assumed. Items are manufactured at stage one and transported to stage two, where the storage capacity of the warehouses is limited. Packaging is completed at stage two (that is, value is added to each item, but no new items are created), and the finished goods inventories are stored which is used to meet the final demand of customers. During each period, the optimized production levels in stage one, as well as transportation levels between stage one and stage two and routing structure from the production plant to warehouses and then to customers, must be determined. The authors consider “different cost structures,” for both manufacturing and transportation. This TSPT model with capacity constraint at both stages is optimized using Genetic Algorithms (GA) and the results obtained are compared with the results of other optimization techniques of complete enumeration, LINDO, and CPLEX.

Genetic Algorithm to Solve Multi-Period, Multi-Product, Bi-Echelon Supply Chain Network Design Problem

2010 ◽  
pp. 487-501
Author(s):  
R. Dhanalakshmi ◽  
P. Parthiban ◽  
K. Ganesh ◽  
T. Arunkumar
Keyword(s):  
Supply Chain ◽  
Supply Chains ◽  
Raw Materials ◽  
Optimization Techniques ◽  
Network Design Problem ◽  
Production Plant ◽  
Two Stage ◽  
Cost Structures ◽  
Multi Stage ◽  
Product Costs

In many multi-stage manufacturing supply chains, transportation related costs are a significant portion of final product costs. It is often crucial for successful decision making approaches in multi-stage manufacturing supply chains to explicitly account for non-linear transportation costs. In this article, we have explored this problem by considering a Two-Stage Production-Transportation (TSPT). A two-stage supply chain that faces a deterministic stream of external demands for a single product is considered. A finite supply of raw materials, and finite production at stage one has been assumed. Items are manufactured at stage one and transported to stage two, where the storage capacity of the warehouses is limited. Packaging is completed at stage two (that is, value is added to each item, but no new items are created), and the finished goods inventories are stored which is used to meet the final demand of customers. During each period, the optimized production levels in stage one, as well as transportation levels between stage one and stage two and routing structure from the production plant to warehouses and then to customers, must be determined. The authors consider “different cost structures,” for both manufacturing and transportation. This TSPT model with capacity constraint at both stages is optimized using Genetic Algorithms (GA) and the results obtained are compared with the results of other optimization techniques of complete enumeration, LINDO, and CPLEX.

Genetic Algorithm to Solve Multi-Period, Multi-Product, Bi-Echelon Supply Chain Network Design Problem

2011 ◽  
pp. 273-289
Author(s):  
R. Dhanalakshmi ◽  
P. Parthiban ◽  
K. Ganesh ◽  
T. Arunkumar
Keyword(s):  
Supply Chain ◽  
Supply Chains ◽  
Raw Materials ◽  
Optimization Techniques ◽  
Network Design Problem ◽  
Production Plant ◽  
Supply Chain Network ◽  
Cost Structures ◽  
Multi Stage ◽  
Product Costs

In many multi-stage manufacturing supply chains, transportation related costs are a significant portion of final product costs. It is often crucial for successful decision making approaches in multi-stage manufacturing supply chains to explicitly account for non-linear transportation costs. In this article, we have explored this problem by considering a Two-Stage Production-Transportation (TSPT). A twostage supply chain that faces a deterministic stream of external demands for a single product is considered. A finite supply of raw materials, and finite production at stage one has been assumed. Items are manufactured at stage one and transported to stage two, where the storage capacity of the warehouses is limited. Packaging is completed at stage two (that is, value is added to each item, but no new items are created), and the finished goods inventories are stored which is used to meet the final demand of customers. During each period, the optimized production levels in stage one, as well as transportation levels between stage one and stage two and routing structure from the production plant to warehouses and then to customers, must be determined. The authors consider “different cost structures,” for both manufacturing and transportation. This TSPT model with capacity constraint at both stages is optimized using Genetic Algorithms (GA) and the results obtained are compared with the results of other optimization techniques of complete enumeration, LINDO, and CPLEX.

Investigating the impact of inventory inaccuracy on the bullwhip effect in RFID-enabled supply chains using colored petri nets

2019 ◽  
Vol 14 (2) ◽  
pp. 360-384 ◽  
Author(s):  
Maria Drakaki ◽  
Panagiotis Tzionas
Keyword(s):  
Supply Chain ◽  
Supply Chains ◽  
Petri Nets ◽  
Information Sharing ◽  
Bullwhip Effect ◽  
Colored Petri Nets ◽  
Content Type ◽  
Multi Stage ◽  
The Impact ◽  
Serial Supply Chains

PurposeInformation distortion results in demand variance amplification in upstream supply chain members, known as the bullwhip effect, and inventory inaccuracy in the inventory records. As inventory inaccuracy contributes to the bullwhip effect, the purpose of this paper is to investigate the impact of inventory inaccuracy on the bullwhip effect in radio-frequency identification (RFID)-enabled supply chains and, in this context, to evaluate supply chain performance because of the RFID technology.Design/methodology/approachA simulation modeling method based on hierarchical timed colored petri nets is presented to model inventory management in multi-stage serial supply chains subject to inventory inaccuracy for various traditional and information sharing configurations in the presence and absence of RFID. Validation of the method is done by comparing results obtained for the bullwhip effect with published literature results.FindingsThe bullwhip effect is increased in RFID-enabled multi-stage serial supply chains subject to inventory inaccuracy. The information sharing supply chain is more sensitive to the impact of inventory inaccuracy.Research limitations/implicationsInformation sharing involves collaboration in market demand and inventory inaccuracy, whereas RFID is implemented by all echelons. To obtain the full benefits of RFID adoption and collaboration, different collaboration strategies should be investigated.Originality/valueColored petri nets simulation modeling of the inventory management process is a novel approach to study supply chain dynamics. In the context of inventory errors, information on RFID impact on the dynamic behavior of multi-stage serial supply chains is provided.

scholarly journals Only as Strong as the Weakest Link

2011 ◽  
Vol 133 (06) ◽  
pp. 26-31 ◽  
Author(s):  
James B. Rice
Keyword(s):  
Supply Chain ◽  
Supply Chains ◽  
Raw Materials ◽  
Supply Chain Risk Management ◽  
Supply Chain Risk ◽  
Risk Monitoring ◽  
Weakest Link ◽  
Internal Operations ◽  
Supplier Risk ◽  
Simulation Exercises

This article discusses why companies need to shore up their supply chains to guard against disasters. Supply chains, which provide raw materials and distribute finished goods to end customers, now extend through many independent companies, and nearly every chain is global. As a consequence, major events from around the world, both natural and man-made, affect the flow of goods and have an increasingly sharp and visibly evident impact on businesses. It is therefore essential that companies identify their entire upstream supply chain—not just their tier-one suppliers but all suppliers and subsuppliers . They should try to understand their downstream customers and intermediaries as well. Businesses also need to conduct a vulnerability assessment for their extended supply chain, not just internal operations. This includes assessing geographic risk, organizational risk, embedded risk, and supplier risk. Organizations should also develop a plan to create a culture that supports supply chain risk management, including active risk monitoring, education, training, and simulation exercises.

scholarly journals Reinforcing the Supply Chain of Umifenovir and Other Antiviral Drugs with Retrosynthetic Software

2021 ◽  
Author(s):  
Yingfu Lin ◽  
Zirong Zhang ◽  
Babak Mahjour ◽  
Di Wang ◽  
Rui Zhang ◽  
...  
Keyword(s):  
Supply Chain ◽  
Supply Chains ◽  
Raw Materials ◽  
Antiviral Drug ◽  
Drug Repurposing ◽  
Antiviral Drugs ◽  
Multiple Drug ◽  
General Strategy ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Abstract The global disruption caused by the 2020 coronavirus pandemic stressed the supply chain of many products, including pharmaceuticals. Multiple drug repurposing studies for COVID-19 are now underway. If a winning therapeutic emerges, it is unlikely that the existing inventory of the medicine, or even the chemical raw materials needed to synthesize it, will be available in the quantities required. We used retrosynthetic software to arrive at alternate chemical supply chains for the antiviral drug umifenovir, as well as eleven other antiviral and anti-inflammatory drugs. We have experimentally validated four routes to umifenovir and one route to bromhexine. In several instances, the software utilizes C–H functionalization logic, and one route to umifenovir employs functionalization of six C–H bonds. The general strategy we apply can be used to identify distinct starting materials, and relieve stress on existing supply chains.

scholarly journals Reinforcing the Supply Chain of COVID-19 Therapeutics with Expert-Coded Retrosynthetic Software

2020 ◽  
Author(s):  
Yingfu Lin ◽  
Zirong Zhang ◽  
babak mahjour ◽  
di wang ◽  
rui zhang ◽  
...  
Keyword(s):  
Artificial Intelligence ◽  
Supply Chain ◽  
General Solution ◽  
Supply Chains ◽  
Raw Materials ◽  
Drug Repurposing ◽  
Hand Sanitizer ◽  
Toilet Paper ◽  
Global Demand

Supply chains become stressed when demand for essential products increases rapidly in times of crisis. This year, the scourge of coronavirus highlighted the fragility of diverse supply chains, affecting the world’s pipeline of hand sanitizer, 1 toilet paper,2 and pharmaceutical starting materials. 3 Many drug repurposing studies are now underway. 4 If a winning therapeutic emerges, it is unlikely that the existing inventory of the medicine, or even the chemical raw materials needed to synthesize it,5 will be available in the quantities required to satisfy global demand. We show the use of a retrosynthetic artificial intelligence (AI) 6-10 to navigate multiple parallel synthetic sequences, and arrive at plausible alternate reagent supply chains for twelve investigational COVID-19 therapeutics. In many instances, the AI utilizes C–H functionalization logic, 11-13 and we have experimentally validated several syntheses, including a route to the antiviral umifenovir that requires functionalization of six C–H bonds. This general solution to chemical supply chain reinforcement will be useful during global disruptions, such as during a pandemic.

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