High Resolution Retinal Imaging Based on Ocular Aberration Measurement and Compensation

2012 ◽  
Vol 246-247 ◽  
pp. 213-218
Author(s):  
Chun Liang ◽  
Jian Xin Shen ◽  
Sai Sai Niu

Ocular retinal imaging is a major diagnostic modality for retinal disease, and can play a critical role for diagnosing systemic diseases such as diabetes and eye-specific diseases such as macular degeneration and diabetic retinopathy, the leading causes of blindness. In order to get high-resolution retinal imaging and develop the low-cost and compact retinal imaging system, we employ micro adaptive optics, which is consisted of wavefront sensor, wavefront corrector and control system. In this paper, the theory, design and testing of the ocular retinal microscopy is detailed, with an emphasis on the eye wavefront aberration describing, aberration detecting method with Hartmann-Shack wavefront sensing and close-loop aberration compensating by micromachined membrane deformable mirrors(MMDM).The ocular retinal microscopy experimental setup is built, the retinal cell imaging had been snapped. It is showed in this work that the ocular retinal microscopy based on adaptive optics system can enable diffraction-limited imaging of micro-scale features of the retina, through real-time compensation of aberrations introduced by the eye.

2017 ◽  
Vol 10 (01) ◽  
pp. 1650038 ◽  
Author(s):  
Junlei Zhao ◽  
Fei Xiao ◽  
Jian Kang ◽  
Haoxin Zhao ◽  
Yun Dai ◽  
...  

It is necessary to know the distribution of the Chinese eye’s aberrations in clinical environment to guide high-resolution retinal imaging system design for large Chinese population application. We collected the monochromatic wave aberration of 332 healthy eyes and 344 diseased eyes in Chinese population across a 6.0-mm pupil. The aberration statistics of Chinese eyes including healthy eyes and diseased eyes were analyzed, and some differences of aberrations between the Chinese and European race were concluded. On this basis, the requirement for adaptive optics (AO) correction of the Chinese eye’s monochromatic aberrations was analyzed. The result showed that a stroke of 20[Formula: see text][Formula: see text]m and ability to correct aberrations up to the 8th Zernike order were needed for reflective wavefront correctors to achieve near diffraction-limited imaging in both groups for a reference wavelength of 550[Formula: see text]nm and a pupil diameter of 6.0[Formula: see text]mm. To verify the analysis mentioned above, an AO flood-illumination system was established, and high-resolution retinal imaging in vivo was achieved for Chinese eye including both healthy and diseased eyes.


2013 ◽  
Vol 33 (2) ◽  
pp. 0211001 ◽  
Author(s):  
周虹 Zhou Hong ◽  
官春林 Guan Chunlin ◽  
戴云 Dai Yun

2011 ◽  
Vol 31 (12) ◽  
pp. 1211001 ◽  
Author(s):  
孔宁宁 Kong Ningning ◽  
李抄 Li Chao ◽  
夏明亮 Xia Mingliang ◽  
齐岳 Qi Yue ◽  
李大禹 Li Dayu ◽  
...  

2015 ◽  
Vol 30 (4) ◽  
pp. 590-595
Author(s):  
潘宇骏 PAN Yu-jun ◽  
韩玉琢 HAN Yu-zhuo ◽  
解洪升 XIE Hong-sheng ◽  
杨乐宝 YANG Le-bao ◽  
王少鑫 WANG Shao-xin ◽  
...  

2011 ◽  
Vol 121-126 ◽  
pp. 877-881
Author(s):  
Hong Xin Zhang ◽  
Xiao Xi Xu

Wavefront correction plays significant role in some fields like astronomical observation, laser processing and medical imaging, etc. Liquid crystal spatial light modulator ( LC SLM) is an ideal device for high-resolution wavefront correction because of its low cost, low consumption, large number of pixels and independent programming control of each unit. It is researched experimentally that LC SLM is used as a wavefront correction device and corrects arbitrary wavefront aberration. Wavefront correction is performed based on phase conjugation and periodic phase modulation with modulo-2π. The experimental results show that the PV value of the irregular wavefront aberration is 1.56λ, RMS value is 0.25 and Strehl ratio is 0.08 before correction, but the PV value of the residual aberration is reduced to 0.26λ, RMS value is 0.02 and Strehl ratio is increased to 0.97 which is approximated diffraction limit after correction. It is proved to be feasible and effective that LC SLM is used to the high-precision and high-resolution wavefront correction.


2006 ◽  
Author(s):  
Daniel C. Gray ◽  
William Merigan ◽  
Bernard P. Gee ◽  
Jessica I. Wolfing ◽  
Jason Porter ◽  
...  

1997 ◽  
Vol 14 (11) ◽  
pp. 2884 ◽  
Author(s):  
Junzhong Liang ◽  
David R. Williams ◽  
Donald T. Miller

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