Significance and Expression of Heat Shock Protein 72 and Glycoprotein96 in Human Gastroenterological Cancers

Heat shock protein 72 (HSP72) and glycoprotein 96 (gp96) are highly expressed in cancer tissues. Recent studies indicate the possible roles of HSP72 and gp96 in the development and progression of gastrointestinal carcinomas but detailed information is still ambiguous. The aim of the study is to investigate the correlation between clinicopathology and immunolocalization of HSP72 and gp96 in human hepatocellular carcinoma. Immunohistochemistry demonstrated that HSP72 and gp96 expression in hepatocellular carcinomas with metastasis was significantly higher than those with non-metastasis. HSP72 and gp96 expression were significantly associated with the presence of tumor infiltration, lymph node and remote metastasis.

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Correlation between Clinicopathology and Expression of Heat Shock Protein 72 in Human Hepatocellular Carcinoma

Applied Mechanics and Materials ◽

10.4028/www.scientific.net/amm.556-562.23 ◽

2014 ◽

Vol 556-562 ◽

pp. 23-26

Author(s):

Yan Fang ◽

Xiao Ping Wang ◽

Huan Ping Lin ◽

Bing Xu ◽

Jing Gang Fang ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Lymph Node ◽

Heat Shock ◽

Heat Shock Protein ◽

Human Hepatocellular Carcinoma ◽

Tumor Infiltration ◽

Heat Shock Protein 72 ◽

Hepatocellular Carcinomas ◽

Cancer Tissues ◽

Hsp72 Expression

Heat shock protein 72 (HSP72) is highly expressed in cancer tissues. Recent studies indicate the possible roles of HSP72 in the development and progression of hepatocellular carcinomas but detailed information is still ambiguous. The aim of the study is to investigate the correlation between clinicopathology and immunolocalization of HSP72 in human hepatocellular carcinoma. Immunohistochemistry demonstrated that HSP72 expression in hepatocellular carcinomas with metastasis was significantly higher than those with non-metastasis. HSP72 expression was significantly associated with the presence of tumor infiltration, lymph node and remote metastasis.

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Significance of Clinicopathology and Expression of Heat Shock Protein 72 in Human Primary Lung Carcinomas

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.459.242 ◽

2012 ◽

Vol 459 ◽

pp. 242-246

Author(s):

Yan Fang ◽

Xiao Ping Wang ◽

Huan Ping Lin ◽

Qiao Xia Wang

Keyword(s):

Lymph Node ◽

Heat Shock ◽

Heat Shock Protein ◽

Lung Carcinoma ◽

Human Lung ◽

Tumor Infiltration ◽

Heat Shock Protein 72 ◽

Lung Carcinomas ◽

Human Lung Carcinoma ◽

Cancer Tissues

Heat shock protein 72 (HSP72) and glycoprotein 96 (gp96) are highly expressed in cancer tissues. Recent studies indicate the possible roles of HSP72 and gp96 in the development and progression of lung carcinomas but detailed information is still ambiguous. The aim of the study is to investigate the correlation between clinicopathology and immunolocalization of HSP72 and gp96 in human lung carcinoma. Immunohistochemistry demonstrated that HSP72 and gp96 expression in lung carcinomas with metastasis was significantly higher than those with non-metastasis. HSP72 and gp96 expression were significantly associated with the presence of tumor infiltration, lymph node and remote metastasis.

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Correlation between Clinicopathology and Expression of Heat Shock Protein 72 and Glycoprotein 96 in Human Esophageal Squamous Cell Carcinoma

Clinical and Developmental Immunology ◽

10.1155/2010/212537 ◽

2010 ◽

Vol 2010 ◽

pp. 1-8 ◽

Cited By ~ 8

Author(s):

Xiaoping Wang ◽

Qiaoxia Wang ◽

Huanping Lin

Keyword(s):

Squamous Cell Carcinoma ◽

Heat Shock ◽

Esophageal Squamous Cell Carcinoma ◽

Heat Shock Protein ◽

Cell Carcinoma ◽

Squamous Cell ◽

Squamous Cell Carcinomas ◽

Heat Shock Protein 72 ◽

Primary Tumors ◽

Esophageal Squamous Cell Carcinomas

Heat shock protein 72 (HSP72) and glycoprotein 96 (gp96) are highly expressed in cancer tissues. Recent studies indicate the possible roles of HSP72 and gp96 in the development and progression of gastrointestinal carcinomas but detailed information is still ambiguous. We investigated the correlation between clinicopathology and expression of HSP72 and gp96 in human esophageal squamous cell carcinoma. The expression of HSP72 and gp96 was studied in 120 human esophageal squamous cell carcinomas with or without metastasis as well as in mucous membrane adjacent to cancers by way of immunohistochemistry. HSP72 immunoreactivities were detected in 112 of 120 primary tumors (93.3%) and in 30 of 120 mucous membranes adjacent to cancers (25.0%). Gp96 detected in esophageal squamous cell carcinoma and inmucous membrane adjacent to cancer was 85.0% and 20.0%, respectively. Both HSP72 and gp96 stained in cytoplasm. HSP72 and gp96 expression in esophageal squamous cell carcinomas withmetastasis was significantly higher than those with nonmetastasis (P<.05). The results indicate that there exists a significant correlation between the expression of HSP72 and gp96 and the progression of esophageal squamous cell carcinomas. HSP72 and gp96 expression were significantly associated with the presence of tumor infiltration, lymph node, and remote metastasis.

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