Neural Network Model for Predicting Anticancer Activity of Pyridopyrimidines Derivatives

2014 ◽  
Vol 905 ◽  
pp. 96-100 ◽  
Author(s):  
Xi Hhua Du ◽  
Wen Chang Zhuang
Keyword(s):  
Neural Network ◽  
Anticancer Activity ◽  
Network Model ◽  
Neural Network Model ◽  
Network Architecture ◽  
Structural Parameters ◽  
Back Propagation ◽  
Molecular Structures ◽  
Molecular Connectivity ◽  
Molecular Connectivity Index

Molecular structures of pyridopyrimidines derivatives as known as dihydrofolate reductase (DHFR) inhibitors were investigated by using the neural network method. Based on the molecular connectivity, molecular connectivity index and molecular electronegativity distance vectors of 32 pyridopyrimidine derivatives were obtained. Among these parameters, three optimized structural parameters 1χ3χ and M17 as the input neurons of the artificial neural network were selected by step-wise regression. Then a 3:4:1 network architecture was employed and a satisfying neural network model for predicting anticancer activity (lg1/C) was constructed with the back-propagation (BP) algorithm. The total correlation coefficient R and the standard deviation S were 0.925 and 0.336 respectively that showed significantly nonlinear relationships between lg1/C and three structural parameters. It was concluded that the predictions of BP neural network are better than those of methods in the literatures.

Application of ANN Back-Propagation for Fracture Design Parameters of Middle Carbon Steel in Extra-Low Cycle Bend Torsion Loading

2013 ◽  
Vol 345 ◽  
pp. 272-276 ◽  
Author(s):  
Hong Yan Duan ◽  
You Tang Li ◽  
Zhi Jia Sun ◽  
Yang Yang Zhang
Keyword(s):  
Neural Network ◽  
Carbon Steel ◽  
Network Model ◽  
Neural Network Model ◽  
Network Architecture ◽  
Back Propagation ◽  
Training Data ◽  
Design Parameters ◽  
Ann Model ◽  
The Neural Network

The fracture problems of medium carbon steel (MCS) under extra-low cycle bend torsion loading were studied using artificial neural networks (ANN) in this paper. The training data were used in the formation of training set of ANN. The ANN model exhibited excellent comparison with the experimental results. It was concluded that predicted fracture design parameters by the trained neural network model seem more reasonable compared to approximate methods. It is possible to claim that, ANN is fairly promising prediction technique if properly used. Training ANN model was introduced at first. And then the Training data for the development of the neural network model was obtained from the experiments. The input parameters, notch depth and tip radius of the notch, and the output, the cycle times of fracture were used during the network training. The neural network architecture is designed. The ANN model was developed using back propagation architecture with three layers jump connections, where every layer was connected or linked to every previous layer. The number of hidden neurons was determined according to special formula. The performance of system is summarized at last. In order to facilitate the comparisons of predicted values, the error evaluation and mean relative error are obtained. The result show that the training model has good performance, and the experimental data and predicted data from ANN are in good coherence.

scholarly journals Dynamic versus static neural network model for rainfall forecasting at Klang River Basin, Malaysia

2012 ◽  
Vol 16 (4) ◽  
pp. 1151-1169 ◽  
Author(s):  
A. El-Shafie ◽  
A. Noureldin ◽  
M. Taha ◽  
A. Hussain ◽  
M. Mukhlisin
Keyword(s):  
Neural Network ◽  
Neural Networks ◽  
Network Model ◽  
Neural Network Model ◽  
Network Architecture ◽  
Rainfall Time Series ◽  
Hydrological Process ◽  
Multi Layer Perceptron ◽  
Rainfall Forecasting ◽  
Unseen Data

Abstract. Rainfall is considered as one of the major components of the hydrological process; it takes significant part in evaluating drought and flooding events. Therefore, it is important to have an accurate model for rainfall forecasting. Recently, several data-driven modeling approaches have been investigated to perform such forecasting tasks as multi-layer perceptron neural networks (MLP-NN). In fact, the rainfall time series modeling involves an important temporal dimension. On the other hand, the classical MLP-NN is a static and has a memoryless network architecture that is effective for complex nonlinear static mapping. This research focuses on investigating the potential of introducing a neural network that could address the temporal relationships of the rainfall series. Two different static neural networks and one dynamic neural network, namely the multi-layer perceptron neural network (MLP-NN), radial basis function neural network (RBFNN) and input delay neural network (IDNN), respectively, have been examined in this study. Those models had been developed for the two time horizons for monthly and weekly rainfall forecasting at Klang River, Malaysia. Data collected over 12 yr (1997–2008) on a weekly basis and 22 yr (1987–2008) on a monthly basis were used to develop and examine the performance of the proposed models. Comprehensive comparison analyses were carried out to evaluate the performance of the proposed static and dynamic neural networks. Results showed that the MLP-NN neural network model is able to follow trends of the actual rainfall, however, not very accurately. RBFNN model achieved better accuracy than the MLP-NN model. Moreover, the forecasting accuracy of the IDNN model was better than that of static network during both training and testing stages, which proves a consistent level of accuracy with seen and unseen data.

scholarly journals Back-propagation neural network model to predict visibility at a road link-level

2020 ◽  
Vol 8 ◽  
pp. 100250
Author(s):  
Venkata R. Duddu ◽  
Srinivas S. Pulugurtha ◽  
Ajinkya S. Mane ◽  
Christopher Godfrey
Keyword(s):  
Neural Network ◽  
Network Model ◽  
Neural Network Model ◽  
Back Propagation ◽  
Back Propagation Neural Network

A novel adaptive and fast deep convolutional neural network for bearing fault diagnosis under different working conditions

2019 ◽  
Vol 234 (4) ◽  
pp. 1167-1182 ◽  
Author(s):  
Kun Xu ◽  
Shunming Li ◽  
Jinrui Wang ◽  
Zenghui An ◽  
Yu Xin
Keyword(s):  
Neural Network ◽  
Fault Diagnosis ◽  
Receptive Field ◽  
Convolutional Neural Network ◽  
Network Model ◽  
Working Conditions ◽  
Neural Network Model ◽  
Network Architecture ◽  
Deep Convolutional Neural Network ◽  
Mechanical Equipment

Deep learning method is gradually applied in the field of mechanical equipment fault diagnosis because it can learn complex and useful features automatically from the vibration signals. Among the many intelligent diagnostic models, convolutional neural network has been gradually applied to intelligent fault diagnosis of bearings due to its advantages of local connection and weight sharing. However, there are still some drawbacks. (1) The training process of convolutional neural network is slow and unstable. It has more training parameters. (2) It cannot perform well under different working conditions, such as noisy environment and different workloads. In this paper, a novel model named adaptive and fast convolutional neural network with wide receptive field is presented to overcome the aforementioned deficiencies. The prime innovations include the following. First, a deep convolutional neural network architecture is constructed using the scaled exponential linear unit activation function and global average pooling. The model has fewer training parameters and can converge rapidly and stably. Second, the model has a wide receptive field with two medium and three small length convolutional kernels. It also has high diagnostic accuracy and robustness when the environment is noisy and workloads are changed compared with other models. Furthermore, to demonstrate how the wide receptive field convolutional neural network model works, the reasons for high model performance are analyzed and the learned features are also visualized. Finally, the wide receptive field convolutional neural network model is verified by the vibration dataset collected in the background of high noise, and the results indicate that it has high diagnostic performance.

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