Research on the Non-Contact Manipulation of Biomaterials in the Stationary Sound Field of Ultrasonic Transducers

2007 ◽  
Vol 353-358 ◽  
pp. 3035-3038 ◽  
Author(s):  
Zong Wei Fan ◽  
Keji Yang ◽  
Zi Chen Chen
Keyword(s):  
Acoustic Radiation ◽  
Ultrasonic Transducer ◽  
Sound Field ◽  
Numerical Data ◽  
Radiation Force ◽  
Axial Direction ◽  
Acoustic Radiation Force ◽  
Ultrasonic Transducers ◽  
Lateral Direction ◽  
Trapping Forces

For applying acoustic radiation force to manipulate biomaterials such as cell, DNA, bio-macromolecule without contact, stationary sound field of an ultrasonic transducer was computed numerically. With the numerical data about the sound field, spatial distribution of the acoustic radiation force was analyzed. Besides the radiation force in the axial direction, trapping forces in the lateral direction were discovered. By moving the reflector continuously and carefully, positions of trapping wells were changed simultaneously, as the result, non-contact manipulation of micro cells was implemented.

scholarly journals Measurements of acoustic radiation force of ultrahigh frequency ultrasonic transducers using model-based approach

2021 ◽  
Author(s):  
Sangnam Kim ◽  
Sunho Moon ◽  
Sunghoon Rho ◽  
Sangpil Yoon
Keyword(s):  
Single Cell ◽  
Acoustic Radiation ◽  
Ultrasonic Transducer ◽  
Radiation Force ◽  
Solid Sphere ◽  
Acoustic Radiation Force ◽  
Ultrasonic Transducers ◽  
Ultrahigh Frequency ◽  
Cell Phenotype ◽  
Target Cells

AbstractEven though ultrahigh frequency ultrasonic transducers over 60 MHz have been used for single cell level manipulation such as intracellular delivery, acoustic tweezers, and stimulation to investigate cell phenotype and cell mechanics, no techniques have been available to measure actual acoustic radiation force (ARF) applied to target cells. Therefore, we have developed an approach to measure ARF of ultrahigh frequency ultrasonic transducers using theoretical model of the dynamics of a solid sphere in a gelatin phantom. To estimate ARF at the focus of 130 MHz transducer, we matched measured maximum displacements of a solid sphere with theoretical calculations. We selected appropriate ranges of input voltages and pulse durations for single cell applications and estimated ARF were in the range of tens of pN to nN. FRET live cell imaging was demonstrated to visualize calcium transport between cells after a target single cell was stimulated by the developed ultrasonic transducer.

scholarly journals Confocal acoustic radiation force optical coherence elastography using a ring ultrasonic transducer

2014 ◽  
Vol 104 (12) ◽  
pp. 123702 ◽  
Author(s):  
Wenjuan Qi ◽  
Rui Li ◽  
Teng Ma ◽  
K. Kirk Shung ◽  
Qifa Zhou ◽  
...  
Keyword(s):  
Acoustic Radiation ◽  
Ultrasonic Transducer ◽  
Radiation Force ◽  
Acoustic Radiation Force ◽  
Optical Coherence

Observations of Tissue Response to Acoustic Radiation Force: Opportunities for Imaging

2002 ◽  
Vol 24 (3) ◽  
pp. 129-138 ◽  
Author(s):  
Kathryn Nightingale ◽  
Rex Bentley ◽  
Gregg Trahey
Keyword(s):  
Acoustic Radiation ◽  
Ex Vivo ◽  
Ultrasonic Transducer ◽  
Radiation Force ◽  
Acoustic Radiation Force ◽  
Tissue Response ◽  
Acoustic Radiation Force Impulse ◽  
Ex Vivo Tissues ◽  
Force Excitation ◽  
Arfi Imaging

Acoustic Radiation Force Impulse (ARFI) imaging is a method for characterizing local variations in tissue mechanical properties. In this method, a single ultrasonic transducer array is used to both apply temporally short localized radiation forces within tissue and to track the resulting displacements through time. In an ongoing study of the response of tissue to temporally short radiation force excitation, ARFI datasets have been obtained of ex vivo tissues under various focal configurations. The goal of this paper is to report observations of the response of tissue to radiation force and discuss the implications of these results in the construction of clinical imaging devices.

Acoustic radiation force experienced by a solid cylinder in a plane progressive sound field

1988 ◽  
Vol 83 (5) ◽  
pp. 1770-1775 ◽  
Author(s):  
Takahi Hasegawa ◽  
Kyosuke Saka ◽  
Naoki Inoue ◽  
Kiichiro Matsuzawa
Keyword(s):  
Acoustic Radiation ◽  
Sound Field ◽  
Radiation Force ◽  
Acoustic Radiation Force ◽  
Solid Cylinder

Acoustic radiation pressure on a rigid sphere in a viscous fluid

1994 ◽  
Vol 447 (1931) ◽  
pp. 447-466 ◽  
Keyword(s):  
Viscous Fluid ◽  
Radiation Pressure ◽  
Special Interest ◽  
Acoustic Radiation ◽  
Sound Field ◽  
Radiation Force ◽  
Acoustic Radiation Force ◽  
Rigid Sphere ◽  
Sphere Radius ◽  
Acoustic Radiation Pressure

The acoustic radiation pressure exerted by an axisymmetric sound field on a rigid sphere suspended freely in a viscous fluid is calculated, the sphere being considered as having an arbitrary radius relative to the sound and viscous wavelengths. The limiting cases of special interest are then investigated, namely, the acoustic radiation force due to a plane progressive and plane standing wave is examined for the limiting cases when the sound wavelength is much more than both the sphere radius and the viscous wavelength and the sphere radius is, in its turn, small or large compared with the viscous wavelength. It is shown that the influence of the viscosity of the fluid surrounding the sphere on the radiation force can be quite considerable in both a quantitative and a qualitative sense. The case of a fastened sphere is also considered.

Spatial distribution of acoustic radiation force modal excitation from focused ultrasonic transducers in air

2017 ◽  
Vol 141 (5) ◽  
pp. 3576-3576
Author(s):  
Thomas M. Huber ◽  
Ian McKeag ◽  
William Riihiluoma ◽  
Christopher Niezrecki ◽  
Songmao Chen ◽  
...  
Keyword(s):  
Spatial Distribution ◽  
Acoustic Radiation ◽  
Radiation Force ◽  
Acoustic Radiation Force ◽  
Ultrasonic Transducers
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