Study on Adhesion and Biocompatibility of Copolymer of MMA-BMA-MAA for Coronary Stents Coatings

Implantation of drug releasing coronary stents has been developed as an useful method for prevention of the restenosis in blood vessels. Copolymers of methyl methacrylate (MMA), butyl methacrylate (BMA) and methacrylic acid (MAA) were prepared as the coating polymer for drug releasing stent. The adhesion of the polymer with metal substrate and the biocompatibility were studied. Effect of the polymer composition on the adhesion between polymer coatings and metal substrate, as well as the effect of the polymer purification method on biocompatibility of the polymer, was studied. The results showed that the copolymer coating has good dry and wet adhesion properties, which can be improved by control of the polymer compositions. Biocompatibility of the prepared copolymer comes within the permission limit.

Download Full-text

pH‐Sensitive methacrylic acid–methyl methacrylate copolymer Eudragit L100 and dimethylaminoethyl methacrylate, butyl methacrylate, and methyl methacrylate tri‐copolymer Eudragit E100

Polymers for Advanced Technologies ◽

10.1002/pat.4780 ◽

2019 ◽

Vol 31 (3) ◽

pp. 440-450 ◽

Cited By ~ 1

Author(s):

Coraline Sester ◽

Fabrice Ofridam ◽

Noureddine Lebaz ◽

Emilie Gagnière ◽

Denis Mangin ◽

...

Keyword(s):

Methyl Methacrylate ◽

Methacrylic Acid ◽

Ph Sensitive ◽

Butyl Methacrylate ◽

Dimethylaminoethyl Methacrylate ◽

Eudragit L100 ◽

Acid Methyl ◽

Eudragit E100 ◽

Methacrylate Copolymer

Download Full-text

Physical Properties of Electropolished CoCrMo Alloy Coated with Biodegradable Polymeric Coatings Releasing Heparin after Prolonged Exposure to Artificial Urine

Materials ◽

10.3390/ma14102551 ◽

2021 ◽

Vol 14 (10) ◽

pp. 2551

Author(s):

Wojciech Kajzer ◽

Janusz Szewczenko ◽

Anita Kajzer ◽

Marcin Basiaga ◽

Joanna Jaworska ◽

...

Keyword(s):

Physical Properties ◽

Crevice Corrosion ◽

Mass Density ◽

Polymer Coatings ◽

Metal Substrate ◽

Reference Level ◽

Polymeric Coatings ◽

Initial State ◽

Cocrmo Alloy ◽

Artificial Urine

In this study, we aimed to determine the effect of long-term exposure to artificial urine on the physical properties of CoCrMo alloy with biodegradable heparin-releasing polymeric coatings. Variants of polymer coatings of poly(L,L-lactide-ɛ-caprolactone) (P(L,L-L/CL)) and poly(D,L-lactide-ɛ-caprolactone) (P(D,L-L/CL)) constituting the base for heparin-releasing (HEP) polyvinyl alcohol (PVA) coatings were analyzed. The coatings were applied by the dip-coating method. Heparin was used to counteract the incrustation process in the artificial urine. The study included tests of wettability, resistance to pitting and crevice corrosion, determination of the mass density of metal ions penetrating into the artificial urine, and the kinetics of heparin release. In addition, microscopic observations of surface roughness and adhesion to the metal substrate were performed. Electrolytically polished CoCrMo samples (as a reference level) and samples with polymer coatings were used for the tests. The tests were conducted on samples in the initial state and after 30, 60, and 90 days of exposure to artificial urine. The analysis of the test results shows that the polymer coatings contribute by improving the resistance of the metal substrate to pitting and crevice corrosion in the initial state and reducing (as compared with the metal substrate) the mass density of metal ion release into the artificial urine. Moreover, the PVA + HEP coating, regardless of the base polymer coatings used, contributes to a reduction in the incrustation process in the first 30 days of exposure to the artificial urine.

Download Full-text