Daily Interruptions of Sedation: A Clinical Approach to Improve Outcomes in Critically Ill Patients

2012 ◽  
Vol 32 (1) ◽  
pp. 43-51 ◽  
Author(s):  
Elizabeth Berry ◽  
Heather Zecca
Keyword(s):  
Critically Ill ◽  
Critically Ill Patients ◽  
Daily Basis ◽  
Psychological Effects ◽  
Perceived Barriers ◽  
Clinical Approach ◽  
Daily Interruption ◽  
Randomized Controlled ◽  
Sedative Agents

The continuous infusion of sedative agents is often necessary for critically ill patients. However, it has been associated with several disadvantages. Numerous interventions to reduce these risks have been evaluated, including the practice of interrupting sedative infusions on a daily basis. A literature search was conducted, and 7 studies were reviewed to evaluate the safety and effectiveness of daily interruption of sedative infusions and its outcomes. The implementation of daily sedation interruptions was suggested to minimize multiple complications associated with continuous sedative infusions and was not associated with intensive care–related complications or long-term psychological effects. Additional studies have revealed perceived barriers to the implementation of daily sedation interruptions. Further randomized controlled trials enrolling larger, more diverse samples are needed to provide more evidence regarding the safety and effectiveness of this intervention.

The Long-term Psychological Effects of Daily Sedative Interruption on Critically Ill Patients

2003 ◽  
Vol 168 (12) ◽  
pp. 1457-1461 ◽  
Author(s):  
John P. Kress ◽  
Brian Gehlbach ◽  
Maureen Lacy ◽  
Neil Pliskin ◽  
Anne S. Pohlman ◽  
...  
Keyword(s):  
Critically Ill ◽  
Critically Ill Patients ◽  
Psychological Effects

scholarly journals Long-term psychological effects of a no-sedation protocol in critically ill patients

Critical Care ◽  
2011 ◽  
Vol 15 (6) ◽  
pp. R293 ◽  
Author(s):  
Thomas Strøm ◽  
Mette Stylsvig ◽  
Palle Toft
Keyword(s):  
Critically Ill ◽  
Critically Ill Patients ◽  
Psychological Effects ◽  
Sedation Protocol

scholarly journals Efficacy And Safety of Family Participate In The Early Mobilization of Critically Ill Patients: Study Protocol For A Randomized Controlled Trial

2021 ◽  
Author(s):  
Yuchen Wu ◽  
Guoqiang Wang ◽  
Bin Li ◽  
Huaping Wei ◽  
Zhigang Zhang ◽  
...  
Keyword(s):  
Critically Ill ◽  
Critically Ill Patients ◽  
Controlled Trial ◽  
Early Mobilization ◽  
Icu Patients ◽  
Outcome Indicators ◽  
Randomized Controlled ◽  
Hospitalization Costs ◽  
Mechanical Ventilation Time

Abstract Background：Long-term immobilization can cause a series of harm to ICU patients, while early rehabilitation can effectively reduce the harm of long-term immobilization and improve the medical outcome of patients. Can family members participate in the early mobilization (FMPiEM) of critically ill patients? Whether the FMPiEM of critically ill patients can reduce delirium, anxiety, depression, post-traumatic stress syndrome and other adverse emotions of ICU patients.Objective: To explore the FMPiEM of critically ill patients on the short-term and long-term outcomes.Methods and design: A single-center randomized controlled trial (RCT) is conducted and reported according to the CONSORT guidelines. A total of 120 samples were randomly assigned to the intervention group (FMPiEM) and the control group ( without-FMPiEM).The primary outcome indicators included the incidence of ICU delirium, acquired infection, ICU mortality, and ICU-acquired weakness (ICU-AW), while the secondary outcome indicators included mechanical ventilation time, length of stay in ICU (ICU LOS), reintubation, unplanned extubation (UEX), hospitalization costs, and patient outcomes. SPSS 22.0 software was used for statistical analysis. Frequency and mean ± standard deviation were used for descriptive analysis. B test, t test or Mann-whitney U test were used for statistical inference.Discussion: FMPiEM of critically ill patients maybe not only reduce the incidence of delirium, ICU-AW, but also reduce the mechanical ventilation time, length of stay in ICU, reintubation, UEX and hospitalization costs of critically ill patients, at the same time, without increasing the acquired infection in ICU.Trial registration: Chinese Clinical Trial Registry, ID:ChiCTR2000028902. Registered on 06 January 2020.

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