scholarly journals Regulation of the Human High Affinity IgE Receptor β-Chain Gene Expression Via an Intronic Element

2003 ◽  
Vol 171 (5) ◽  
pp. 2478-2484 ◽  
Author(s):  
Kyoko Takahashi ◽  
Chiharu Nishiyama ◽  
Masanari Hasegawa ◽  
Yushiro Akizawa ◽  
Chisei Ra
Keyword(s):  
Gene Expression ◽  
Chain Gene ◽  
Ige Receptor ◽  
High Affinity ◽  
High Affinity Ige Receptor ◽  
Β Chain

scholarly journals FHL3 negatively regulates human high-affinity IgE receptor β-chain gene expression by acting as a transcriptional co-repressor of MZF-1

2005 ◽  
Vol 386 (1) ◽  
pp. 191-200 ◽  
Author(s):  
Kyoko TAKAHASHI ◽  
Chiyuki MATSUMOTO ◽  
Chisei RA
Keyword(s):  
Gene Expression ◽  
Transcriptional Repression ◽  
Chain Gene ◽  
Dependent Manner ◽  
Ige Receptor ◽  
High Affinity ◽  
High Affinity Ige Receptor ◽  
Β Chain

The high-affinity IgE receptor FcεRI plays a key role in triggering allergic reactions. We recently reported that human FcεRI β-chain gene expression was down-regulated by a transcription factor, MZF-1, through an element in the fourth intron. In the present study, we found that this transcriptional repression by MZF-1 required FHL3 (four and a half LIM domain protein 3) as a cofactor. Yeast two-hybrid and immunoprecipitation assays demonstrated that FHL3 bound MZF-1 in vitro and in vivo. Overexpression of FHL3 in KU812 cells suppressed the β-chain promoter activity through the element in the fourth intron in an MZF-1-dependent manner. Furthermore, results from pull-down assays and gel-filtration chromatography employing nuclear extracts indicated that MZF-1 and FHL3 formed a complex of high molecular mass with some additional proteins in the nucleus. Granulocyte–macrophage colony-stimulating factor, which was reported to decrease FcεRI expression, induced the accumulation of FHL3 in the nucleus, in accordance with the repressive role of FHL3 in β-chain gene expression.

Hyperexpression of the High-Affinity IgE Receptor-β Chain in Chronic Allergic Keratoconjunctivitis

2009 ◽  
Vol 50 (6) ◽  
pp. 2871 ◽  
Author(s):  
Akira Matsuda ◽  
Yoshimichi Okayama ◽  
Nobuyuki Ebihara ◽  
Norihiko Yokoi ◽  
Junji Hamuro ◽  
...  
Keyword(s):  
Ige Receptor ◽  
High Affinity ◽  
High Affinity Ige Receptor ◽  
Β Chain

scholarly journals High-affinity IgE receptor-β chain expression in human mast cells

2008 ◽  
Vol 336 (2) ◽  
pp. 229-234 ◽  
Author(s):  
Akira Matsuda ◽  
Yoshimichi Okayama ◽  
Nobuyuki Ebihara ◽  
Norihiko Yokoi ◽  
Peisong Gao ◽  
...  
Keyword(s):  
Mast Cells ◽  
Ige Receptor ◽  
High Affinity ◽  
Human Mast Cells ◽  
High Affinity Ige Receptor ◽  
Β Chain

The E237G polymorphism of the high-affinity IgE receptor β chain and asthma

2004 ◽  
Vol 93 (5) ◽  
pp. 499-503 ◽  
Author(s):  
Zhang Xiaozhu ◽  
Zhang Weidong ◽  
Qiu Diwen ◽  
Sandford Andrew ◽  
Tan W. Cheng
Keyword(s):  
Ige Receptor ◽  
High Affinity ◽  
High Affinity Ige Receptor ◽  
Β Chain

Transcriptional regulation of the human high affinity IgE receptor α-chain gene

2002 ◽  
Vol 38 (16-18) ◽  
pp. 1193-1199 ◽  
Author(s):  
Kyoko Takahashi ◽  
Chiharu Nishiyama ◽  
Chisei Ra
Keyword(s):  
Transcriptional Regulation ◽  
Chain Gene ◽  
Ige Receptor ◽  
High Affinity ◽  
Α Chain ◽  
High Affinity Ige Receptor

Measurement of canine IgE using the alpha chain of the human high affinity IgE receptor

2001 ◽  
Vol 78 (3-4) ◽  
pp. 349-355 ◽  
Author(s):  
K. Stedman ◽  
K. Lee ◽  
S. Hunter ◽  
B. Rivoire ◽  
C. McCall ◽  
...  
Keyword(s):  
Ige Receptor ◽  
Alpha Chain ◽  
High Affinity ◽  
High Affinity Ige Receptor
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