scholarly journals “Alternatively Activated” Dendritic Cells Preferentially Secrete IL-10, Expand Foxp3+CD4+ T Cells, and Induce Long-Term Organ Allograft Survival in Combination with CTLA4-Ig

2006 ◽  
Vol 177 (9) ◽  
pp. 5868-5877 ◽  
Author(s):  
Yuk Yuen Lan ◽  
Zhiliang Wang ◽  
Giorgio Raimondi ◽  
Wenhan Wu ◽  
Bridget L. Colvin ◽  
...  
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Cd4 T Cells ◽  
Allograft Survival ◽  
Alternatively Activated

scholarly journals Differential regulation of naïve and memory CD4+ T cells by alternatively activated dendritic cells

2008 ◽  
Vol 84 (1) ◽  
pp. 124-133 ◽  
Author(s):  
Amy E. Anderson ◽  
Bethan L. Sayers ◽  
Muzlifah A. Haniffa ◽  
David J. Swan ◽  
Julie Diboll ◽  
...  
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Cd4 T Cells ◽  
Differential Regulation ◽  
Memory Cd4 T Cells ◽  
Alternatively Activated

scholarly journals Human dendritic cells sequentially matured with CD4+ T cells as a secondary signal favor CTL and long-term T memory cell responses

2012 ◽  
Vol 45 (1) ◽  
pp. 33-43 ◽  
Author(s):  
Thomas Simon ◽  
Séverine Tanguy-Royer ◽  
Pierre-Joseph Royer ◽  
Nicolas Boisgerault ◽  
Jihane Frikeche ◽  
...  
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Cd4 T Cells ◽  
Memory Cell ◽  
Cell Responses ◽  
Human Dendritic Cells

Active suppression of allogeneic proliferative responses by dendritic cells after induction of long-term allograft survival by CTLA4Ig

Blood ◽  
2003 ◽  
Vol 101 (8) ◽  
pp. 3325-3333 ◽  
Author(s):  
Cécile Guillot ◽  
Séverine Ménoret ◽  
Carole Guillonneau ◽  
Cécile Braudeau ◽  
Maria G. Castro ◽  
...  
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Molecular Mechanisms ◽  
Transforming Growth Factor ◽  
Combined Treatment ◽  
Interleukin 10 ◽  
No Production ◽  
Allograft Survival

Abstract Costimulatory blockade using cytotoxic T lymphocyte–associated antigen 4 immunoglobulin (CTLA4Ig) efficiently down-regulates immune responses in animal models and is currently used in autoimmune and transplantation clinical trials, but the precise cellular and molecular mechanisms involved remain unclear. Rats that received allogeneic heart transplants and were treated with adenoviruses coding for CTLA4Ig show long-term allograft survival. The immune mechanisms regulating induction of long-term allograft acceptance were analyzed in splenocytes using mixed leukocyte reactions (MLRs). MLRs of splenocytes but not purified T cells from CTLA4Ig-treated rats showed higher than 75% inhibition compared with controls. Splenocytes from CTLA4Ig-treated rats inhibited proliferation of naive and allogeneically primed splenocytes or T cells. MLR suppression was dependent on soluble secreted product(s). Production of soluble inhibitory product(s) was triggered by a donor antigen-specific stimulation and inhibited proliferation in an antigen-nonspecific manner. CTLA4Ig levels in the culture supernatant were undetectable and neither interleukin-10 (IL-10), transforming growth factor β1 (TGFβ1), IL-4, nor IL-13 were responsible for suppression of MLRs. Inhibition of nitrous oxide (NO) production or addition of IL-2 could not restore proliferation independently, but the combined treatment synergistically induced proliferation comparable with controls. Stimulation of APCs using tumor necrosis factor (TNF)–related activation-induced cytokine (TRANCE) or CD40L and addition of IL-2 normalized MLRs of CTLA4Ig-treated splenocytes. Finally, dendritic cells (DCs), but not T cells, from CTLA4Ig-treated rats inhibited naive MLRs. Altogether, these results provide evidence that after in vivo CTLA4Ig treatment, splenocytes, and in particular DCs, can inhibit alloantigen-induced proliferative responses through secretion of inhibitory products, thus promoting alloantigen-specific tolerance in vivo.

scholarly journals Long-Term Cardiac Allograft Survival across an MHC Mismatch after “Pruning” of Alloreactive CD4 T Cells

2008 ◽  
Vol 180 (10) ◽  
pp. 6593-6603 ◽  
Author(s):  
Min Hu ◽  
Debbie Watson ◽  
Geoff Y. Zhang ◽  
Nicole Graf ◽  
Yuan M. Wang ◽  
...  
Keyword(s):  
T Cells ◽  
Cd4 T Cells ◽  
Cardiac Allograft ◽  
Allograft Survival

CD69+ Th2-type CD4+ T Cells are Responsible for Long-term Memory Responses to Allergens in the Lungs

2021 ◽  
Vol 147 (2) ◽  
pp. AB174
Author(s):  
Takao Kobayashi ◽  
Koji Iijima ◽  
Jyoti Lama ◽  
Hirohito Kita
Keyword(s):  
T Cells ◽  
Cd4 T Cells ◽  
Long Term Memory ◽  
Term Memory

scholarly journals Human anogenital monocyte-derived dendritic cells and langerin+cDC2 are major HIV target cells

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Jake W. Rhodes ◽  
Rachel A. Botting ◽  
Kirstie M. Bertram ◽  
Erica E. Vine ◽  
Hafsa Rana ◽  
...  
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Cd4 T Cells ◽  
Pathogen Detection ◽  
Hiv Transmission ◽  
Sexual Transmission ◽  
Mononuclear Phagocytes ◽  
Target Cells ◽  
Epithelial Surface ◽  
Transmission Studies

AbstractTissue mononuclear phagocytes (MNP) are specialised in pathogen detection and antigen presentation. As such they deliver HIV to its primary target cells; CD4 T cells. Most MNP HIV transmission studies have focused on epithelial MNPs. However, as mucosal trauma and inflammation are now known to be strongly associated with HIV transmission, here we examine the role of sub-epithelial MNPs which are present in a diverse array of subsets. We show that HIV can penetrate the epithelial surface to interact with sub-epithelial resident MNPs in anogenital explants and define the full array of subsets that are present in the human anogenital and colorectal tissues that HIV may encounter during sexual transmission. In doing so we identify two subsets that preferentially take up HIV, become infected and transmit the virus to CD4 T cells; CD14+CD1c+ monocyte-derived dendritic cells and langerin-expressing conventional dendritic cells 2 (cDC2).

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