Correlation between Predictors for Diabetic Gastroparesis and Gastric Emptying Scintigraphy

2009 ◽  
Vol 45 (3) ◽  
pp. 175
Author(s):  
Kyung-Ju Lee ◽  
Kyoung-Ho Ryu ◽  
Jin-Ook Chung ◽  
Dong-Hyeok Cho ◽  
Dong-Jin Chung ◽  
...  
2017 ◽  
Vol 26 (1) ◽  
pp. 17-23 ◽  
Author(s):  
Zeinab Alipour ◽  
Foad Khatib ◽  
Seyed Masoud Tabib ◽  
Hamid Javadi ◽  
Esmail Jafari ◽  
...  

2010 ◽  
Vol 138 (5) ◽  
pp. S-720
Author(s):  
Daniil Rolshud ◽  
Harvey A. Ziessman ◽  
Kerry B. Dunbar ◽  
Gerard E. Mullin ◽  
John O. Clarke

2016 ◽  
Vol 151 (1) ◽  
pp. 87-96.e6 ◽  
Author(s):  
Anthony Lembo ◽  
Michael Camilleri ◽  
Richard McCallum ◽  
Ramon Sastre ◽  
Cristian Breton ◽  
...  

2021 ◽  
Vol 75 (2) ◽  
pp. 159-164
Author(s):  
Martina Horváthová ◽  
Zuzana Bárdyová ◽  
Darina Budošová ◽  
Rastislav Husťak

Introduction: Gastric emptying scintigraphy (GES) is a safe, noninvasive method for assessing the ability of the stomach to empty which has been used clinically for many years. It is considered as a “gold standard” to assess gastric emptying of both solids and liquids allowing assessment of early, mid and late emptying, each of which may be altered by pathology. The aim of the study was to analyse standard diagnostic approach and evaluate patients` radiation exposure, who underwent GES in Slovakia. Methods: A retrospective cohort study included 55 patients from 2 departments of nuclear medicine (department A, B). Patients’ radiation exposure was determined by dosimetry program IDAC-Dose2.1. The radiopharmaceutical 99mTc-DTPA, always with the same activity, was applied orally to patients at Department B. The applied activity of the radiopharmaceutical at GES was 185 MBq. The radiopharmaceutical 99mTc MAA, with various activity, was applied orally to patients at Department A. Results: According to ICRP60, the eff ective dose (ED) of every patient undergoing GES was 0.77 mSv and, according to ICRP103, the dose was 0.836 mSv at Department B. Patients at Department A were exposed to ionizing radiation with 5-times lower intensity, compared with patients at Department B. It was caused by radiopharmaceutical activity correction. The ED medians according to ICRP60, and according to ICRP103 were 0.167 mSv (range 0.105–0.208 mSv) and 0.181 mSv (range 0.113–0.226 mSv) at Department A, respectively. Discussion: Adequate correction of applied radiopharmaceutical activity is an essential part of GES guidelines and in accordance with ALARA principles. For the accuracy of GES examination, it is necessary to follow a standard 4-hour protocol and an approach which ensures full-featured utilization of the examination while decreasing patient`s radiation exposure. Conclusion: The results of our study show relatively low ED associated with GES, but also confi rm that the GES methodology significantly affects the patient`s radiation exposure


2014 ◽  
Vol 32 (2) ◽  
pp. 139-145 ◽  
Author(s):  
Netanella Danielli Miller ◽  
Elad Schiff ◽  
Eran Ben-Arye ◽  
Joelle Singer ◽  
Tsachi Tsadok Perets ◽  
...  

Objectives The aim of this preliminary study was to compare the effectiveness of domperidone and acupuncture for the management of diabetic gastroparesis. Methods This was a preliminary, prospective non-randomised, unblinded case-crossover study conducted in patients with longstanding, uncontrolled diabetes mellitus and gastroparesis. All patients received domperidone (20 mg four times a day) for 12 weeks, followed by a 2–3 week washout period, and then biweekly acupuncture treatments for 8 weeks. Gastric emptying rate, glucose and glycated haemoglobin (HbA1C) levels were measured at start and end of each treatment period. At each of these timepoints patients completed the Gastroparesis Cardinal Symptom Index (GCSI), the Satisfaction with Life Scale (SWLS), and the Short-Form 36 Health Survey Update (SF-36). Results The trial was curtailed after only eight participants could be recruited in 3 years. The mean age of patients was 57.1±9.9 years, the male:female ratio was 1:7 and mean body mass index (kg/m2) was 25.2±1.2. There was no change in any of the outcome parameters after treatment with domperidone. Acupuncture was associated with a decrease in scores for almost all cardinal symptoms of the GCSI, as well as in increased total score on the SWLS (p=0.002) and the social functioning domain of the SF-36 (p=0.054). Acupuncture did not lead to an improvement in gastric emptying, or glucose control from baseline. Conclusions Acupuncture treatment may lead to symptomatic improvement in patients with diabetic gastroparesis. Within the limitations of this preliminary, non-randomised and unblinded study, it appears that this effect may be due to non-specific mechanisms.


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