Can We Restore the Endothelial Dysfunction in Patients with Essential Hypertension with Calcium Channel Blockers?

2000 ◽  
Vol 30 (8) ◽  
pp. 1010
Author(s):  
Jang Ho Bae
Keyword(s):  
Essential Hypertension ◽  
Endothelial Dysfunction ◽  
Calcium Channel ◽  
Calcium Channel Blockers ◽  
Channel Blockers

scholarly journals Calcium Channel Blockers Shorten the Periodicity of Ultradian Variation in Blood Pressure in Patients with Essential Hypertension.

1998 ◽  
Vol 21 (3) ◽  
pp. 179-186 ◽  
Author(s):  
Hiroshi Kawamura ◽  
Hiromi Mitsubayashi ◽  
Tomoaki Saito ◽  
Katsuo Kanmatsuse ◽  
Noboru Saito
Keyword(s):  
Blood Pressure ◽  
Essential Hypertension ◽  
Calcium Channel ◽  
Calcium Channel Blockers ◽  
Channel Blockers

Calcium-channel blockers and sodium intake: A controlled study in patients with essential hypertension

1989 ◽  
Vol 3 (2) ◽  
pp. 135-140 ◽  
Author(s):  
Ferruccio Galletti ◽  
Pasquale Strazzullo ◽  
Francesco P. Cappuccio ◽  
Gianvincenzo Barba ◽  
Nicola Giorgione ◽  
...  
Keyword(s):  
Essential Hypertension ◽  
Calcium Channel ◽  
Calcium Channel Blockers ◽  
Sodium Intake ◽  
Controlled Study ◽  
Channel Blockers

scholarly journals A Comparative study to assess the effectiveness and safety of cilnidipine versus amlodipine in patients with newly diagnosed essential hypertension: insights from a single centre prospective observational study

2017 ◽  
Vol 6 (3) ◽  
pp. 648
Author(s):  
Ramya Y. S. ◽  
Jayanthi C. R. ◽  
Raveendra K. R. ◽  
Pradeep Kumar B. T.
Keyword(s):  
Blood Pressure ◽  
Essential Hypertension ◽  
Side Effects ◽  
Calcium Channel ◽  
Calcium Channel Blockers ◽  
Channel Blockers ◽  
Newly Diagnosed ◽  
Open Label ◽  
Amlodipine Group ◽  
Pedal Edema

Background: Calcium channel blockers (CCBs) are proposed to play a pivotal role for the management and control of hypertension. Dihydropyridine-type calcium channel blockers (CCBs) like Amlodipine are frequently used because for their strong antihypertensive and minimal adverse side effects. However, it is commonly associated with the causation of pedal edema among the patients. Cilnidipine, which is a novel new generation calcium channel blocker, is presumed to cause lesser pedal edema with a satisfactory clinical control of hypertension along with negligible side effects. This study was carried out to compare clinical effectiveness and safety profile between Amlodipine and Cilnidipine.Methods: A prospective, randomized, open label study of 12 weeks’ duration was conducted amongst 60 patients with newly diagnosed essential hypertension. 30 patients of one group received Tab. Amlodipine 5 mg and 30 patients of same age groups received Tab. Cilnidipine 10mg.Results: There was a highly statistically significant decrease in the level of blood pressure in the Cilnidipine group compared to the Amlodipine group mainly at day 90 (P<0.001). Cilnidipine treated group had a fall in blood pressure of 23 ± 8 mmHg and the Amlodipine group had a decrease in the blood pressure of 12±7mmHg. Additionally, there was also significant reduction in pulse rate in the cilnidipine group. Only 4 patients in the Cilnidipine group developed ankle edema which completely disappeared at the end of 12 weeks of therapy compared to 9 patients in the Amlodipine group which persistently worsened at the completion of the study.Conclusions: Our study concluded that cilnidipine was a well-tolerated anti-hypertensive drug amongst patients with newly diagnosed essential hypertension and associated with minor adverse effects.

Case 36: Orthostatic Hypertension

2019 ◽  
pp. 215-218
Author(s):  
Peter Novak
Keyword(s):  
Blood Pressure ◽  
Essential Hypertension ◽  
Calcium Channel ◽  
Calcium Channel Blockers ◽  
Cerebral Perfusion ◽  
Cerebral Vessels ◽  
Channel Blockers ◽  
Orthostatic Hypertension ◽  
Orthostatic Blood Pressure

Orthostatic hypertension is a syndrome associated with a rise in orthostatic blood pressure, for example in essential hypertension, diabetes, and dysautonomia. Therapy with calcium channel blockers may reduce hypertension and also may improve cerebral perfusion since calcium channel blockers dilate cerebral vessels.

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