Effect of Interleukin-6 (IL-6) on the Vascular Smooth Muscle Contraction in Abdominal Aorta of Rats with Streptozotocin-Induced Diabetes

2012 ◽  
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Muscle Contraction ◽  
Abdominal Aorta ◽  
Interleukin 6 ◽  
Smooth Muscle Contraction ◽  
Streptozotocin Induced Diabetes ◽  
Vascular Smooth Muscle Contraction

Inhibitory effect of interleukin-6 on vascular smooth muscle contraction

1994 ◽  
Vol 266 (3) ◽  
pp. H898-H902 ◽  
Author(s):  
F. Ohkawa ◽  
U. Ikeda ◽  
K. Kawasaki ◽  
E. Kusano ◽  
M. Igarashi ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Muscle Contraction ◽  
Interleukin 6 ◽  
Smooth Muscle Contraction ◽  
Inhibitory Effect ◽  
Sprague Dawley ◽  
Intracellular Cgmp ◽  
Dependent Relationship ◽  
Vascular Smooth Muscle Contraction

Our objective was to investigate the direct effect of interleukin-6 (IL-6) on the vascular smooth muscle contraction. We measured the contraction of endothelium-denuded aortic rings isolated from Sprague-Dawley rats. We also investigated the involvement of vasodilator prostaglandin and guanosine 3',5'-cyclic monophosphate (cGMP) productions in the effect of IL-6 using cultured rat vascular smooth muscle cells (VSMC). Exposing the aortic rings to recombinant murine IL-6 (50 U/ml) for 180 min significantly suppressed the phenylephrine (10(-9)-10(-5) M)-induced contraction. This inhibitory effect of IL-6 on the contraction tended to exhibit a dose-dependent relationship (0.5-50 U/ml). The effect of IL-6 was totally eliminated in the presence of indomethacin (10(-5) M). The release of immunoreactive 6-ketoprostaglandin F1 alpha from cultured rat VSMC was significantly increased by exposure to IL-6. Intracellular cGMP concentration in VSMC was not affected by IL-6. In conclusion, IL-6 is a potent inhibitor of the alpha-adrenergic-stimulated contraction of vascular smooth muscle. Its action is endothelium independent and mediated by the increased synthesis of prostacyclin in VSMC.

Multiple mechanisms of vascular smooth muscle contraction

1990 ◽  
Vol 183 (2) ◽  
pp. 173-174
Author(s):  
H. Karaki ◽  
K. Sato ◽  
M. Hori ◽  
H. Ozaki ◽  
K. Sakata ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Muscle Contraction ◽  
Smooth Muscle Contraction ◽  
Vascular Smooth Muscle Contraction

Vascular smooth muscle contraction induced by Na+ channel activators, veratridine and batrachotoxin

1991 ◽  
Vol 205 (2) ◽  
pp. 199-202 ◽  
Author(s):  
Shinjoh Masayoshi ◽  
Nakaki Toshio ◽  
Otsuka Yukari ◽  
Sasakawa Nobuyuki ◽  
Kato Ryuichi
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Muscle Contraction ◽  
Smooth Muscle Contraction ◽  
Na Channel ◽  
Vascular Smooth Muscle Contraction
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