Different fracture risk profile in patients treated with anti-osteoporotic drugs in real-life

In this retrospective study, we intended to investigate the baseline fracture risk profile in patients who started treatment with different anti-osteoporotic medications. We analyzed retrospectively the fracture risk calculated with DeFRA, a validated FRAX derived tool, in women who started an anti-osteoporotic treatment from 2010 to 2017. We analyzed baseline data of 12,024 post-menopausal women aged over 50 years. Teriparatide initiators had a baseline 10-year risk of major osteoporotic fracture of 82.1% with a Standard Deviation (SD) of 66.5%. Denosumab initiators and zoledronic acid initiators had a greater 10-year baseline risk of fracture (54.3%, SD 46.5% and 47.0%, SD 42.0 respectively) than patients initiated on alendronate (24.9%, SD 34.6%) and patients initiated on risedronate (23.9%, SD 24.1%). Using DeFRA, a FRAX™ derived tool, we showed significantly different fracture risk profiles in women who were started on various therapeutic agents for the treatment of osteoporosis in routine clinical practice.

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Raloxifene for the prevention and treatment of osteoporosis in post-menopausal women

10.1002/14651858.cd003112 ◽

2000 ◽

Author(s):

A Cranney ◽

V Robinson ◽

G Guyatt ◽

N Krolicki ◽

JD Adachi ◽

...

Keyword(s):

Treatment Of Osteoporosis ◽

Menopausal Women ◽

Prevention And Treatment ◽

Post Menopausal

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SAT0364 Are differences of hip shape responsible for increased femoral neck fracture risk in post-menopausal women?:

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2012-eular.3310 ◽

2013 ◽

Vol 71 (Suppl 3) ◽

pp. 595.2-595

Author(s):

A.G.S. Oldroyd ◽

M. Nickkho-Amiry ◽

B. Evans ◽

C. Greenbank ◽

M. Bukhari

Keyword(s):

Femoral Neck ◽

Fracture Risk ◽

Femoral Neck Fracture ◽

Menopausal Women ◽

Neck Fracture ◽

Post Menopausal

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Bone density and geometry in assessing hip fracture risk in post-menopausal women

British Journal of Radiology ◽

10.1259/bjr/37401526 ◽

2007 ◽

Vol 80 (959) ◽

pp. 893-897 ◽

Cited By ~ 13

Author(s):

S Gnudi ◽

E Sitta ◽

N Fiumi

Keyword(s):

Hip Fracture ◽

Bone Density ◽

Fracture Risk ◽

Hip Fracture Risk ◽

Menopausal Women ◽

Post Menopausal

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Human parathyroid hormone for the treatment of osteoporosis in post-menopausal women.

10.1002/14651858.cd003111 ◽

2001 ◽

Author(s):

Lisa M. Waldegger ◽

Ann Cranney ◽

Jonathan Adachi ◽

Peter Tugwell ◽

George A Wells

Keyword(s):

Parathyroid Hormone ◽

Human Parathyroid Hormone ◽

Treatment Of Osteoporosis ◽

Menopausal Women ◽

Post Menopausal

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A Preliminary Evaluation of the Ability of Keratotic Tissue to Act as a Prognostic Indicator of Hip Fracture Risk

Clinical Medicine Insights Arthritis and Musculoskeletal Disorders ◽

10.1177/1179544117754050 ◽

2018 ◽

Vol 11 ◽

pp. 117954411775405 ◽

Cited By ~ 1

Author(s):

J Renwick Beattie ◽

Diane Feskanich ◽

M Clare Caraher ◽

Mark R Towler

Keyword(s):

Raman Spectroscopy ◽

Hip Fracture ◽

Fracture Risk ◽

Spectroscopic Analysis ◽

Prognostic Indicator ◽

Health Study ◽

Preliminary Evaluation ◽

Predictive Values ◽

Menopausal Women ◽

Post Menopausal

Studies have shown that Raman spectroscopic analysis of fingernail clippings can help differentiate between post-menopausal women who have and who have not suffered a fracture. However, all studies to date have been retrospective in nature, comparing the proteins in nails sourced from women, post-fracture. The objective of this study was to investigate the potential of a prospective test for hip fracture based on spectroscopic analysis of nail tissue. Archived toenail samples from post-menopausal women aged 50 to 63 years in the Nurses’ Health Study were obtained and analysed by Raman spectroscopy. Nails were matched case-controls sourced from 161 women; 82 who underwent a hip fracture up to 20 years after nail collection and 81 age-matched controls. A number of clinical risk factors (CRFs) from the Fracture Risk Assessment (FRAX) tool had been assessed at toenail collection. Using 80% of the spectra, models were developed for increasing time periods between nail collection and fracture. Scores were calculated from these models for the other 20% of the sample and the ability of the score to predict hip fracture was tested in model with and without the CRFs by comparing the odds ratios (ORs) per 1 SD increase in standardised predictive values. The Raman score successfully distinguished between hip fracture cases and controls. With only the score as a predictor, a statistically significant OR of 2.2 (95% confidence interval [CI]: 1.5-3.1) was found for hip fracture for up to 20 years after collection. The OR increased to 3.8 (2.6-5.4) when the CRFs were added to the model. For fractures limited to 13 years after collection, the OR was 6.3 (3.0-13.1) for the score alone. The test based on Raman spectroscopy has potential for identifying individuals who may suffer hip fractures several years in advance. Higher powered studies are required to evaluate the predictive capability of this test.

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