scholarly journals Patterns of Nerve Conduction Abnormalities in Patients with Type 2 Diabetes Mellitus According to the Clinical Phenotype Determined by the Current Perception Threshold

2018 ◽  
Vol 42 (6) ◽  
pp. 519 ◽  
Author(s):  
Joong Hyun Park ◽  
Jong Chul Won
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Nerve Conduction ◽  
Clinical Phenotype ◽  
Perception Threshold ◽  
Current Perception Threshold ◽  
Conduction Abnormalities

scholarly journals Assessment of Peripheral Neuropathy Using Measurement of the Current Perception Threshold with the Neurometer® in Patients with Type 2 Diabetes Mellitus

2005 ◽  
Vol 33 (4) ◽  
pp. 442-453 ◽  
Author(s):  
R Matsutomo ◽  
K Takebayashi ◽  
Y Aso
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Peripheral Neuropathy ◽  
Sensory Nerve ◽  
Significant Negative Correlation ◽  
Diabetic Patients ◽  
Perception Threshold ◽  
Current Perception Threshold

Measurement of current perception threshold (CPT) using the Neurometer® at 2000, 250 and 5 Hz assesses function in three different nerve fibre types. This method was used to investigate peripheral neuropathy in 116 patients with type 2 diabetes mellitus and 38 healthy controls. The CPT at 2000 Hz was significantly higher in diabetic patients than in controls, and showed a significant negative correlation with motor and sensory nerve conduction velocities. At 250 Hz, CPT showed a significant positive correlation with the vibration perception threshold. At 5 Hz, the change in systolic blood pressure in the Schellong test in patients with hypoaesthesia tended to be less than in those with normal sensation or hyperaesthesia. Significantly higher CPT values were obtained in patients with proliferative diabetic retinopathy and macroalbuminuria. These data suggest that CPT is useful in detecting abnormalities of myelinated as opposed to unmyelinated nerve fibres in patients with type 2 diabetes.

scholarly journals Diabetic Distal Symmetrical Polyneuropathy: Correlation of Clinical, Laboratory, and Electrophysiologic Studies in Patients with Type 2 Diabetes Mellitus

2020 ◽  
Vol 2020 ◽  
pp. 1-11
Author(s):  
Yi-Ching Weng ◽  
Sung-Sheng Tsai ◽  
Rong-Kuo Lyu ◽  
Chun-Che Chu ◽  
Long-Sun Ro ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Nerve Conduction ◽  
Clinical Laboratory ◽  
Thermal Threshold ◽  
Distal Symmetrical Polyneuropathy ◽  
Electrophysiologic Studies

This cross-sectional study is aimed at determining the prevalence of distal symmetrical polyneuropathy (DSPN) and diabetic peripheral neuropathic pain (DPNP) in participants with type 2 diabetes mellitus (T2DM); finding the risk factors for DSPN and DPNP via biochemical tests; and correlating DSPN and DPNP with the results of electrophysiologic studies, quantitative sensory tests, and neurologic examination. The 145 participants with T2DM enrolled were divided into the DSPN (abnormal nerve conduction studies (NCS) with signs of polyneuropathy), subclinical DSPN (abnormal NCS without signs of polyneuropathy), minimal DSPN (normal NCS with signs of polyneuropathy), and no DSPN groups. The biochemical risk factors of diabetic peripheral neuropathy were investigated. Neurologic examinations, laboratory tests, NCS, vibration threshold tests, and thermal threshold tests were conducted. The modified Michigan Neuropathy Screening Instrument (mMNSI) and Douleur Neuropathique 4 were used to evaluate the severity of DSPN and DPNP, respectively. In all, 30% of participants had DSPN and 11% had DPNP. DSPN correlated strongly with male gender and higher glycohaemoglobin levels; NCS abnormality correlated with higher glycohaemoglobin levels; DSPN severity correlated with NCS of each stimulating nerve. DPNP commonly occurred with clinical and electrophysiologic evidence of DSPN. Symptomatic diabetic polyneuropathy significantly correlated with longer disease duration, higher glycohaemoglobin levels, and abnormal vibration tests. The thermal threshold test combined with nerve conduction tests could detect most of the patients with DSPN, subclinical DSPN, and minimal DSPN. Poor diabetic control was independently associated with the development of DSPN. DPNP was associated with DSPN. The combination of thermal threshold tests with NCS can potentially provide the diagnosis of DSPN.

scholarly journals Electrophysiological Changes of Motor Nerves in Patients with Type 2 Diabetes Mellitus

1970 ◽  
Vol 5 (2) ◽  
pp. 14-17 ◽  
Author(s):  
S Sultana ◽  
N Begum ◽  
L Ali ◽  
MM Hossain ◽  
NB Bhowmik ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Nerve Conduction ◽  
Motor Nerve ◽  
Motor Nerve Conduction ◽  
Duration Of Diabetes ◽  
Motor Nerves ◽  
Type 2 Diabetic

Peripheral neuropathy is a common disabling complication in patients with diabetes and this complication is related to the duration of the disease process. Nerve conduction study is widely used for the assessment of diabetic polyneuropathy not only to evaluate the degree of abnormality but also to document serial changes in the clinical course of the disease. This study was designed to characterize motor nerve conduction abnormalities in subjects having relatively shorter and longer duration of type 2 diabetes mellitus and also to assess whether time related variable like duration of diabetes has any influence on motor nerve function of the subjects. Forty-four type 2 diabetic subjects were included in two groups:- Group B consisted of 23 diabetic subjects having duration of diabetes for 5-10 years (shorter duration) and Group C consisted of 21 diabetic subjects having duration of diabetes for 10-15 years (longer duration). Twenty-five age and BMI matched healthy subjects without family history of diabetes were included as Group A (non-diabetic) subjects. Motor nerve conduction velocities, action potential amplitudes and latencies of ulnar and peroneal nerves were measured by standard Nerve Conduction Velocity- Electromyography (NCV-EMG) equipment. Motor conduction parameters like ulnar compound muscle action potential (U CMAP), peroneal compound muscle action potential (P CMAP) and peroneal  nerve conduction velocity (P NCV) were found to be significantly reduced (p<0.001, <0.01, <0.01 respectively) in diabetic group with shorter duration of diabetes(Group B) in comparison to non-diabetic control group (Group A). In the diabetic group with relatively longer duration of diabetes (Group C) motor nerve conduction parameters like U CMAP and P NCV were significantly reduced (p<0.001, <0.01 respectively). The results showed that in the type 2 diabetic population, motor nerve conduction parameters were affected early and there was gradual deterioration of motor function as duration of diabetes increased. Though previous studies on diabetic neuropathy suggest that abnormalities of sensory nerve conduction are early features of diabetic nerve damage and sensory nerves are more susceptible to fall prey to metabolic assaults, the present study indicates that motor nerves are also involved and the neuropathic changes assessed by electro diagnostic methods in motor nerves may occur early in patients with type 2 diabetes mellitus. So, there may be some genetic and biochemical basis (other than hyperglycaemia) for early motor involvement in type 2 diabetic population of Bangladesh. Key words: Diabetic neuropathy, electrophysiology, nerve conduction, electromyography. DOI: 10.3329/jafmc.v5i2.4576 JAFMC Bangladesh Vol.5(2) (December) 2009, pp.14-17

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