Imaging for branching vascular network in polypoidal choroidal vasculopathy

Background: To compare the vascular lesion size using optical coherence tomography angiography and indocyanine green angiography in eyes with polypoidal choroidal vasculopathy. Methods: Treatment-naïve cases (46 eyes of 44 patients) with polypoidal choroidal vasculopathy were retrospectively analyzed. The comparison of mean area of branching vascular network and polyp detection rate was done between indocyanine green angiography and optical coherence tomography angiography and correlated with various optical coherence tomography features. Results: The mean age of the study patients was 62.33 ± 10.74 years. The mean branching vascular network size was 7.47 ± 5.74 and 7.51 ± 5.69 mm² in indocyanine green angiography and optical coherence tomography angiography, respectively, with an excellent correlation (r = 0.997). Optical coherence tomography angiography overestimated (mean ± SD: 0.28 ± 0.19 mm²) and underestimated branching vascular network area (0.36 ± 0.33 mm²) in 23 eyes each as compared to indocyanine green angiography. However, the difference in branching vascular network size was not statistically significant (p = 0.53). Indocyanine green angiography and optical coherence tomography angiography could identify polyps in 43 of 46 (93.48%) and 32 of 46 (69.57%) patients, respectively. Conclusion: Branching vascular network size measurements with indocyanine green angiography and optical coherence tomography angiography were comparable and showed significant correlation, albeit the polyp identification rate was lower with optical coherence tomography angiography. Optical coherence tomography angiography may serve as a useful substitute to indocyanine green angiography in measurements of branching vascular network for photodynamic therapy and follow-up of polypoidal choroidal vasculopathy eyes.

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Characterizing Branching Vascular Network Morphology in Polypoidal Choroidal Vasculopathy by Optical Coherence Tomography Angiography

Scientific Reports ◽

10.1038/s41598-018-37384-y ◽

2019 ◽

Vol 9 (1) ◽

Cited By ~ 6

Author(s):

Chu-Hsuan Huang ◽

Po-Ting Yeh ◽

Yi-Ting Hsieh ◽

Tzyy-Chang Ho ◽

Chung-May Yang ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Polypoidal Choroidal Vasculopathy ◽

Optical Coherence Tomography Angiography ◽

Vascular Network ◽

Optical Coherence ◽

Branching Vascular Network ◽

Choroidal Vasculopathy ◽

Network Morphology

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Clinical features and prognosis of polypoidal choroidal vasculopathy with different morphologies of branching vascular network on optical coherence tomography angiography

Scientific Reports ◽

10.1038/s41598-021-97340-1 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Shang-Te Ma ◽

Chu-Hsuan Huang ◽

Yun-Chia Chang ◽

Tso-Ting Lai ◽

Yi-Ting Hsieh ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Clinical Features ◽

Polypoidal Choroidal Vasculopathy ◽

Optical Coherence Tomography Angiography ◽

Vascular Network ◽

Optical Coherence ◽

Branching Vascular Network ◽

Type 3 ◽

Choroidal Vasculopathy

AbstractThis study highlights the clinical features and treatment response of polypoidal choroidal vasculopathy (PCV) among three different branching vascular network (BVN) morphologies in optical coherence tomography angiography (OCTA), and further correlates the BVN features with those under fluorescent angiography (FA) and indocyanine green angiography (ICGA). In total, we reviewed 70 eyes with PCV followed up for > 12 months. OCTA, ICGA and FA images were obtained at baseline and post-treatments. BVN was assessed using OCTA and divided into three types by a previously described BVN classification: type 1 (trunk), type 2 (glomeruli), and type 3 (stick). At baseline, type 1 BVN had the poorest vision and thinnest subfoveal choroidal thickness (SFCT), whereas type 3 had the best vision and thickest SFCT. The aforementioned trend sustained after treatments. Each BVN morphology in OCTA showed typical features in FA + ICGA and encompassed significant correlation (p = 0.004). In conclusion, OCTA is an innovative imaging tool for the detection and classification of BVN in PCV. Furthermore, OCTA has advantages of being noninvasive and free of systemic toxicities. The BVN can be divided into three types based on morphological characteristics in OCTA, which play crucial roles in clinical presentations and treatment outcomes.

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Photodynamic therapy for polypoidal choroidal vasculopathy: Vaso-occlusive effect on the branching vascular network and origin of recurrence

Japanese Journal of Ophthalmology ◽

10.1007/s10384-007-0501-y ◽

2008 ◽

Vol 52 (2) ◽

pp. 108-115 ◽

Cited By ~ 31

Author(s):

Won Ki Lee ◽

Phil Young Lee ◽

Sang Kyu Lee

Keyword(s):

Photodynamic Therapy ◽

Polypoidal Choroidal Vasculopathy ◽

Vascular Network ◽

Branching Vascular Network ◽

Choroidal Vasculopathy

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Modern aspects of polypoidal choroidal vasculopathy diagnosis and treatment

Ophthalmology journal ◽

10.17816/ov16034 ◽

2019 ◽

Vol 12 (3) ◽

pp. 93-100

Author(s):

Konstantin V. Sokolov ◽

Alexey K. Smirnov

Keyword(s):

Clinical Practice ◽

Polypoidal Choroidal Vasculopathy ◽

European Population ◽

Age Related Macular Degeneration ◽

Universal Method ◽

Distinctive Features ◽

Anti Vegf ◽

Age Related ◽

Branching Vascular Network ◽

Choroidal Vasculopathy

Polypoidal choroidal vasculopathy (PCV) is one of the choroidal neovascularization forms, being a subtype of neovascular age-related macular degeneration (nAMD). These two conditions share many characteristics, while PCV has some distinctive features with aneurysmal dilatations (polyps) at the end of abnormal branching vascular network being the most specific of them. Low documented incidence of PCV in European population (up to 13%) may be related to the absence of indocyanin-green angiography (ICG) the only reliable method for PCV diagnosis confirmation in routine clinical practice. In that regard, there should be a universal method of treatment suitable for any patient with nAMD irrespectively of whether he or she has PCV. To date, there is no common approach to PCV treatment anti-VEGF therapy, photodynamic therapy (PDT), and combination of these methods are used in clinical practice. Key diagnostic criteria helping to suspect the presence of PCV without ICG as well as results of clinical trials aimed at assessing effectiveness of different anti-VEGF agents as monotherapy or in combination with PDT are described in this article.

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Polypoidal Choroidal Vasculopathy Complicating Retinal Laser in Quiescent Uveitis

Case Reports in Ophthalmological Medicine ◽

10.1155/2019/6147063 ◽

2019 ◽

Vol 2019 ◽

pp. 1-5

Author(s):

Tomas R. Burke ◽

Susan L. Lightman

Keyword(s):

Lupus Erythematosus ◽

Polypoidal Choroidal Vasculopathy ◽

Retinal Vasculitis ◽

Subretinal Fluid ◽

Fundus Fluorescein Angiography ◽

Pan Retinal Photocoagulation ◽

Branching Vascular Network ◽

Previously Treated ◽

Choroidal Vasculopathy ◽

Retinal Photocoagulation

A 58-year-old Afro-Caribbean gentleman with a diagnosis of quiescent systemic lupus erythematosus- (SLE-) related occlusive retinal vasculitis was previously treated with sector pan-retinal photocoagulation in his right eye to control temporal retinal neovascularization. At routine review he was found to have a focal area of subretinal fluid in the temporal macula sparing an ischaemic fovea. Fundus fluorescein angiography and indocyanine green angiography confirmed a branching vascular network (BVN) and terminal polys (i.e., polypoidal choroidal vasculopathy (PCV)). Interestingly, the BVN arose within an old laser scar. To our knowledge this is the first report of PCV in uveitis in an Afro-Caribbean patient and of the lesions arising within a laser scar.

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