scholarly journals Comparing absolute lymphocyte count to total lymphocyte count, as a CD4 T cell surrogate, to initiate antiretroviral therapy

2011 ◽  
Vol 3 (3) ◽  
pp. 265 ◽  
Author(s):  
Srirangaraj Sreenivasan ◽  
Venkatesha Dasegowda
Keyword(s):  
T Cell ◽  
Antiretroviral Therapy ◽  
Lymphocyte Count ◽  
Absolute Lymphocyte Count ◽  
Total Lymphocyte Count ◽  
Cd4 T Cell ◽  
Total Lymphocyte

Correlation between total and CD4 lymphocyte counts in HIV infection: not making the good an enemy of the not so perfect

1996 ◽  
Vol 7 (6) ◽  
pp. 422-428 ◽  
Author(s):  
E J Beck ◽  
E J Kupek ◽  
M M Gompels ◽  
A J Pinching
Keyword(s):  
T Cell ◽  
Hiv Infection ◽  
Lymphocyte Count ◽  
Cell Subset ◽  
Total Lymphocyte Count ◽  
Aids Patients ◽  
T Cell Subset ◽  
Total Lymphocyte ◽  
Asymptomatic Patients ◽  
Cd4 Lymphocyte

The aim of this study was to assess the correlation and average cost of total lymphocyte count compared with CD4 count as a broad estimate of immunosuppression in HIV-1 infected individuals. Spearman's partial rank correlation were calculated between total lymphocyte count, absolute CD4 count and CD4 per cent stratified by stage of HIV-1 infection for routinely collected samples. Data were collected prospectively from a T cell-subset register combined with clinical data obtained retrospectively from case notes of HIV-infected patients managed at St Mary's Hospital, London 1982-1991. Costing data were obtained through a survey of the departments of haematology and immunology 1989 90 prices . The correlation between 1534 paired absolute lymphocyte count and CD4 lymphocyte count was found to be high R 0.76 . When analysed by stage of HIV infection, the correlation increased from R 0.64 for asymptomatic patients, to R 0.72 for patients with symptomatic non-AIDS HIV infection and R 0.73 for AIDS patients. Correlations between absolute lymphocyte count and CD4 per cent were considerably weaker: R 0.41 all paired counts; R 0.32 for asymptomatic patients; R 0.25 for symptomatic non-AIDS patients; R 0.32 for AIDS patients. Average cost was 8 per full blood count compared with 38 per T-cell subset analysis. The high correlation between total and CD4 lymphocyte counts, especially for patients with symptomatic HIV disease, demonstrates the suitability of the use of total lymphocyte count in the absence of CD4 counts. Given the considerably lower prices of total lymphocyte counts compared with T-cell subset analysis, this is particularly relevant for developing countries.

Absolute or total lymphocyte count as a marker for the CD4 T lymphocyte criterion for initiating antiretroviral therapy

AIDS ◽  
2003 ◽  
Vol 17 (6) ◽  
pp. 917-919 ◽  
Author(s):  
Mark A Jacobson ◽  
Lea Liu ◽  
Hassan Khayam-Bashi ◽  
Steven G Deeks ◽  
Frederick M Hecht ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
T Lymphocyte ◽  
Lymphocyte Count ◽  
Total Lymphocyte Count ◽  
Total Lymphocyte

Rapid declines in total lymphocyte count and hemoglobin in HIV infection begin at CD4 lymphocyte counts that justify antiretroviral therapy

AIDS ◽  
2003 ◽  
Vol 17 (1) ◽  
pp. 119-121 ◽  
Author(s):  
Stephen J Gange ◽  
Bryan Lau ◽  
John Phair ◽  
Sharon A Riddler ◽  
Roger Detels ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
Hiv Infection ◽  
Lymphocyte Count ◽  
Total Lymphocyte Count ◽  
Total Lymphocyte ◽  
Cd4 Lymphocyte
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