scholarly journals Gellan gum-based mucoadhesive microspheres of almotriptan for nasal administration: Formulation optimization using factorial design, characterization, and in vitro evaluation

2014 ◽  
Vol 6 (4) ◽  
pp. 267 ◽  
Author(s):  
Zaheer Abbas ◽  
Sachin Marihal
Keyword(s):  
Factorial Design ◽  
Gellan Gum ◽  
Nasal Administration ◽  
In Vitro Evaluation ◽  
Formulation Optimization

FORMULATION AND IN-VITRO EVALUATION OF ZOLMITRIPTAN IN SITU GEL FOR NASAL ADMINISTRATION

INDIAN DRUGS ◽  
2013 ◽  
Vol 50 (12) ◽  
pp. 54-58
Author(s):  
P. H Patil ◽  
◽  
V. S Belgamwar ◽  
D. A Patel ◽  
S. J. Surana
Keyword(s):  
Evaluation Studies ◽  
Methyl Cellulose ◽  
Nasal Delivery ◽  
Nasal Administration ◽  
Histopathological Study ◽  
In Situ Gel ◽  
In Vitro Evaluation ◽  
Effective Delivery

The aim of present investigation was formulation and in-vitro evaluation of in situ gel for the nasal delivery of zolmitriptan. The in situ gel was prepared by temperature induced gelation technique using Pluronic with mucoadhesive polymer hydroxy propyl methyl cellulose K4 M in different ratios. The in situ gels so prepared were characterized and from the evaluation studies, batch PH2 was optimized and further subjected for stability studies at 30±2°C and 60±5% RH for 90 days. These formulations retained good stability at accelerated conditions and also did not show any remarkable damage to nasal mucosa in histopathological study. Owing to these properties it can be used as an effective delivery system for the nasal route.

Formulation optimization and in vitro evaluation of orally disintegrating domperidone tablets

2013 ◽  
Vol 13 (4) ◽  
pp. 278-281
Author(s):  
Jing YANG ◽  
Zhao WANG ◽  
MiaoMiao XI ◽  
Wei SONG ◽  
Nai LIAO ◽  
...  
Keyword(s):  
In Vitro Evaluation ◽  
Formulation Optimization

scholarly journals Systematic Development of Transethosomal Gel System of Piroxicam: Formulation Optimization, In Vitro Evaluation, and Ex Vivo Assessment

2016 ◽  
Vol 18 (1) ◽  
pp. 58-71 ◽  
Author(s):  
Varun Garg ◽  
Harmanpreet Singh ◽  
Amit Bhatia ◽  
Kaisar Raza ◽  
Sachin Kumar Singh ◽  
...  
Keyword(s):  
Ex Vivo ◽  
In Vitro Evaluation ◽  
Formulation Optimization ◽  
Systematic Development ◽  
Gel System

In vitro evaluation of spray-dried mucoadhesive micropheres for nasal administration.

1992 ◽  
Vol 18 (5) ◽  
pp. 581-597 ◽  
Author(s):  
P. Vidgren ◽  
M. Vidgren ◽  
J. Arppe ◽  
T. Hakuli ◽  
E. Laine ◽  
...  
Keyword(s):  
Nasal Administration ◽  
In Vitro Evaluation ◽  
Spray Dried

Factorial design based curcumin ethosomal nanocarriers for the skin cancer delivery: in vitro evaluation

2019 ◽  
Vol 29 (3) ◽  
pp. 291-311 ◽  
Author(s):  
Malleswara Rao Peram ◽  
Sunil Jalalpure ◽  
Vijay Kumbar ◽  
Sachin Patil ◽  
Sumit Joshi ◽  
...  
Keyword(s):  
Skin Cancer ◽  
Factorial Design ◽  
In Vitro Evaluation

scholarly journals In vitro evaluation of a self-emulsifying drug delivery system (SEDDS) for nasal administration of dimenhydrinate

2019 ◽  
Vol 9 (5) ◽  
pp. 945-955 ◽  
Author(s):  
Christina Leichner ◽  
Randi Angela Baus ◽  
Max Jelkmann ◽  
Melanie Plautz ◽  
Jan Barthelmes ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Nasal Administration ◽  
In Vitro Evaluation

In-Situ Gelling System based on Thiolated Gellan Gum as New Carrier for Nasal Administration of Dimenhydrinate

2009 ◽  
Vol 2 (2) ◽  
pp. 544-550
Author(s):  
Hitendra Mahajan ◽  
Hannan Shaikh ◽  
Surendra Gattani ◽  
Pankaj Nerkar
Keyword(s):  
Nasal Mucosa ◽  
Histopathological Examination ◽  
Polymer Concentration ◽  
Gellan Gum ◽  
Nasal Administration ◽  
In Vitro Permeation ◽  
Permeation Studies ◽  
In Situ Gelling

The purpose of the present study was to develop intranasal delivery system of dimenhydrinate using thiolated gellan gum and formulations were modulated so as to have gelation at physiological ion content after intranasal administration.  Gelation was determined by physical appearance.  The mucoadhesive force in terms of detachment stress, determined using sheep nasal mucosa, increased with increasing concentration of thiolated polymer. The results of in vitro drug permeation studies across sheep nasal mucosa indicate that effective permeation could be significantly increased by using in situ gelling formulation with thiolated polymer concentration.  Finally, histopathological examination did not detect any changes during in vitro permeation studies.  In conclusion the gel formulation of dimenhydrinate with in situ gelling and mucoadhesive properties with increased permeation rate is promising for prolonging nasal residence time and thereby nasal absorption.

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