Mauriac syndrome, a rare complication of insulin dependent diabetes mellitus

2015 ◽  
Vol 2 (4) ◽  
pp. 234
Author(s):  
Mrigind Singh ◽  
Baljeet Maini ◽  
Chandan Mago ◽  
H. M.Haq Nawaz ◽  
AnandKumar Bhardwaj
2021 ◽  
Vol 8 (4) ◽  
pp. 1340
Author(s):  
Parthasarathi Hota

A case presented here depicting testicular necrosis in a 45 years old male patient with diabetes mellitus. Past history suggestive of diabetes with very irregular medication. Patient presented with gradually increasing right testicular enlargement for three weeks. Ultrasonography showed abscess formation with no vascularity in right testis. Right orchiectomy done. Histopathology report confirmed testicular necrosis. Testicular necrosis is a common complication after torsion which leads to orchiectomy. In those cases, patients present with acute onset pain in the scrotum, usually unilateral. On examination there is acutely tender testis with red and angry looking overlying skin. In diabetic patients, urinary tract infections are common occurrence as well as epididymo-orchitis. Patients present with testicular pain with fever, leucocytosis etc. But testicular necrosis is extremely rare. Long term complications specific to diabetes mellitus include retinopathy, nephropathy and neuropathy. Patients with all forms of diabetes of sufficient duration, including insulin-dependent diabetes mellitus and non-insulin-dependent diabetes mellitus, are vulnerable to these complications, which cause serious morbidity. Testicular necrosis is a very rare complication of diabetes mellitus. An internet search did not reveal any article of testicular necrosis as a complication of diabetes. A case of unilateral testicular necrosis as a complication of diabetes mellitus is presented here for the first time. Probably accelerated microangiopathy along with poor control of blood glucose led to this unique complication.


1996 ◽  
Vol 76 (03) ◽  
pp. 328-332 ◽  
Author(s):  
Bernd Jilma ◽  
Peter Fasching ◽  
Christine Ruthner ◽  
Anna Rumplmayr ◽  
Sabine Ruzicka ◽  
...  

SummaryBased on findings that showed increased P-selectin expression on platelets and on choroidal microvessels of patients with insulin dependent diabetes mellitus (IDDM), we hypothesized that also plasma concentrations of circulating (c)P-selectin would be increased in these patients.The aim of this study was to compare the plasma levels of cP-selec-tin between non-smoking patients with IDDM, treated with an intensified insulin therapy, and healthy controls. The study design was prospective, cross-sectional and analyst-blinded. Subjects were matched individually for sex, age and body mass index. Plasma levels of cP-selectin and of von Willebrand antigen (vWF-Ag) were determined by enzyme linked immunoassays.Forty-two pairs were available for intergroup comparison. Median plasma concentrations of cP-selectin in patients with IDDM (285 ng/ml; interquartile range: 233-372) were on average 21% higher than those of controls (236 ng/ml; interquartile range: 175-296; p = 0.004). Also, median plasma levels of vWF-Ag were 10% higher in patients (96 U/dl; interquartile range: 82-127) than controls (87 U/dl; interquartile range: 70-104; p = 0.025). There was no correlation between plasma concentrations of cP-selectin and vWF-Ag levels in either group (p ώ0.05).In conclusion, our results of increased cP-selectin levels are in line with increased P-selectin expression on platelets and on choroidal microvessels found in patients with IDDM. In view of the currently developed small molecule inhibitors of cell adhesion molecules, these independent observations together may provide a sound rationale to select P-selectin as a target for treating or preventing IDDM-associated micro- or macrovascular complications.


Diabetes ◽  
1986 ◽  
Vol 35 (2) ◽  
pp. 139-142 ◽  
Author(s):  
S. Srikanta ◽  
A. T. Ricker ◽  
D. K. McCulloch ◽  
J. S. Soeldner ◽  
G. S. Eisenbarth ◽  
...  

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