Effect of lactoferrin in the prevention of late-onset sepsis in preterm neonates: a randomized-controlled trial

2021 ◽  
Vol 34 (1) ◽  
pp. 1
Author(s):  
MarwaM Farag ◽  
OmneyaM.K.B Eldin ◽  
MennattAllahH Attia ◽  
NadaI.A Morsi ◽  
RaniaM.A.S El haddad
Keyword(s):  
Randomized Controlled Trial ◽  
Late Onset ◽  
Controlled Trial ◽  
Preterm Neonates ◽  
Randomized Controlled ◽  
Late Onset Sepsis

Probiotic Effects on Late-onset Sepsis in Very Preterm Infants: A Randomized Controlled Trial

PEDIATRICS ◽  
2013 ◽  
Vol 132 (6) ◽  
pp. 1055-1062 ◽  
Author(s):  
S. E. Jacobs ◽  
J. M. Tobin ◽  
G. F. Opie ◽  
S. Donath ◽  
S. N. Tabrizi ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Preterm Infants ◽  
Late Onset ◽  
Controlled Trial ◽  
Very Preterm Infants ◽  
Very Preterm ◽  
Randomized Controlled ◽  
Late Onset Sepsis

scholarly journals Effectiveness of Kangaroo Mother Care in Intubated Preterm Neonates 28 to 36 Weeks Gestational Age, Weighing 600 to 2000 Grams at Birth: A Randomized Controlled Trial

2021 ◽  
Vol 55 (9) ◽  
Author(s):  
Shary May M. Baton ◽  
Maria Esterlita T. Villanueva-Uy ◽  
Socorro De Leon-Mendoza
Keyword(s):  
Randomized Controlled Trial ◽  
Hospital Stay ◽  
Late Onset ◽  
Controlled Trial ◽  
Intervention Group ◽  
Kangaroo Mother Care ◽  
Preterm Neonates ◽  
Control Group ◽  
Low Birth Weight Infants ◽  
Randomized Controlled

Background. Kangaroo Mother Care (KMC) is the standard of care for stable low birth weight infants. Provision of KMC to intubated preterm infants may also be beneficial, but strong evidence is still lacking. Objective. To determine the effectiveness of KMC in decreasing mortality among intubated preterm neonates. Study Design. This is a non-blinded, parallel, non-inferiority randomized controlled trial. Methodology. All intubated, preterm admissions, 28-36 weeks gestation, weighing 600-2000 grams, with respiratory distress were included. They were randomized to the intervention group who received KMC for 2-4 hours daily while intubated and the control group who received care inside an incubator. Participants’ physiologic status – before, during, and after the intervention – was recorded. The primary outcome was mortality. Secondary outcomes included comorbidities, days intubated, and hospital stay. Results. There was a total of 32 patients. The risk of dying in the KMC group (n=16) was significantly reduced by 78% (RR 0.22; 95% CI 0.06 - 0.87 p=0.009). The KMC patients were also less likely to have hypothermia, nosocomial pneumonia, NEC, and late-onset neonatal sepsis (p<0.05). The KMC group had higher blood sugar levels (110 vs. 58, p=0.001) and required fewer days of intubation (3.5 vs.1.5 days, p<0.000) compared to the control group. There was no difference in the duration of the hospital stay. Conclusion. KMC is effective in decreasing mortality among intubated preterm neonates. Other comorbidities and days of intubation were also reduced.

scholarly journals Oropharyngeal administration of colostrum for preventing necrotizing enterocolitis and late-onset sepsis in preterm infants with gestational age ≤ 32 weeks: a pilot single-center randomized controlled trial

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Xia OuYang ◽  
Chang-Yi Yang ◽  
Wen-Long Xiu ◽  
Yan-Hua Hu ◽  
Su-Su Mei ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Preterm Infants ◽  
Enteral Feeding ◽  
Late Onset ◽  
Controlled Trial ◽  
Control Group ◽  
Single Center ◽  
Randomized Controlled ◽  
Late Onset Sepsis ◽  
Full Enteral Feeding

Abstract Background Oropharyngeal administration of colostrum (OAC) may provide immunoprotective and anti-inflammatory effects that potentially reduce the incidence of necrotizing enterocolitis (NEC) and late-onset sepsis and improve short-term outcomes. Our objective was to evaluate the role of OAC in the early prevention of NEC and late-onset sepsis in preterm infants with gestational age (GA) ≤ 32 weeks. Methods A pilot, single-center, 1:1 parallel randomized controlled trial was conducted in a 40-bed tertiary neonatal intensive care unit (NICU) in China from 1 January 2019 to 30 September 2020. Preterm infants were randomly divided into two groups with GA ≤ 32 weeks. The OAC group included preterm infants who received 0.4 ml of maternal colostrum via the oropharyngeal route every 3 h for 10 days beginning within the first 48 h after birth, and the control group included preterm infants who received normal saline instead. Data from the two groups were collected and compared. Results A total of 127 infants in the OAC group and 125 infants in the control group were enrolled. The incidence of NEC (Bell stage 2 or 3) and late-onset sepsis were lower in the OAC group [2.36% vs. 10.40%, relative risk (RR) 0.23 (95% confidence interval (CI) 0.07, 0.78), adjusted RR 0.23 (95% CI 0.06, 0.84); 4.72% vs. 13.60%, RR 0.35 (95% CI 0.14, 0.85), adjusted RR 0.36 (95% CI 0.14, 0.95)]. In addition, the incidence of proven sepsis and intraventricular hemorrhage (IVH) (stage 3 or 4) were lower in the OAC group [2.36% vs. 8.80%, RR 0.27 (95% CI 0.08, 0.94); 1.57% vs. 7.20%, RR 0.22 (95% CI 0.05, 0.99)], and the time to achieve full enteral feeding was shorter (23.13 ± 9.45 days vs. 28.50 ± 14.80 days). No adverse reactions were observed in either group. Conclusions Oropharyngeal administration of colostrum is a safe and simple NICU procedure that may yield a potential effect in decreasing the incidences of NEC, late-onset sepsis, and severe IVH and shorten the time to achieve full enteral feeding in preterm infants with GA ≤ 32 weeks. Trial registration Chinese Clinical Trial Registry, ChiCTR1900023697, Registered 8 June 2019, retrospectively registered.

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