scholarly journals Left ventricular restrictive physiology in kids with atrial septal defects: Something unexpected!

2021 ◽  
Vol 0 (0) ◽  
pp. 0
Author(s):  
Gianfranco Butera ◽  
Alessia Faccini ◽  
Matteo Casenghi ◽  
Mario Carminati
Keyword(s):  
Left Ventricular ◽  
Septal Defects ◽  
Atrial Septal Defects ◽  
Restrictive Physiology

scholarly journals Hidden burden of arrhythmias in patients with small atrial septal defects: a nationwide study

Open Heart ◽  
2019 ◽  
Vol 6 (1) ◽  
pp. e001056
Author(s):  
Sebastian Udholm ◽  
Camilla Nyboe ◽  
Andrew Redington ◽  
Jens Erik Nielsen-Kudsk ◽  
Jens Cosedis Nielsen ◽  
...  
Keyword(s):  
Volume Overload ◽  
Left Ventricular ◽  
Adult Patients ◽  
Heart Volume ◽  
Nationwide Study ◽  
Septal Defects ◽  
Atrial Septal Defects ◽  
Background Population ◽  
Number Of Patients ◽  
Increased Risk

BackgroundIn recent Danish nationwide register-based study, adults with small, unrepaired atrial septal defects (ASD) have increased risk of pneumonia, atrial fibrillation (AF) and stroke. Moreover, they revealed higher mortality than the background population.ObjectiveIn this nationwide study, we evaluate the hidden burden of atrial and ventricular arrhythmias in adult patients with a small, unrepaired ASD without a previous diagnosis of AF.MethodsAll Danish patients, aged 18–65, diagnosed between 1953 and 2011 with an unrepaired ASD and no documented AF were invited for 7 days Holter-recording, echocardiography and 6 min walk test. The first 48 hours Holter-recording was completely analysed, while only AF was screened for throughout all 7 days. Furthermore, the entire patient group were characterised using the unique Danish registries.ResultsA total of 151 patients (mean age 32 years) were included. Approximately 80% of the patients had spontaneous closure of their defect. Despite this, occult arrhythmias were frequent. The most common arrhythmia was supraventricular tachycardia (n=24, 16%) with non-sustained atrial arrhythmias in 21 patients and AF in two patients. A considerable number of patients had non-sustained ventricular tachycardia (n=12, 8%). Patients with ASD and tachyarrhythmias had increased right ventricular to left ventricular diastolic area in echocardiography and higher age when compared with ASD patients without arrhythmias.ConclusionAdult patients with small, unrepaired ASD have a hidden burden of both atrial and ventricular tachyarrhythmias. The mechanism likely relates to the residua of previous right-heart volume overload and incomplete reverse remodelling. Our results support guidelines recommending continued follow-up of patients with small, unrepaired ASD.

Left ventricular rotation and right–left ventricular interaction in congenital heart disease: the acute effects of interventional closure of patent arterial ducts and atrial septal defects

2013 ◽  
Vol 24 (4) ◽  
pp. 661-674 ◽  
Author(s):  
Kai T. Laser ◽  
Nikolaus A. Haas ◽  
Markus Fischer ◽  
Sheeraz Habash ◽  
Franziska Degener ◽  
...  
Keyword(s):  
Volume Overload ◽  
Left Ventricular ◽  
Diastolic Filling ◽  
Healthy Children ◽  
Septal Defects ◽  
Atrial Septal Defects ◽  
Apical Rotation ◽  
Maximal Torsion ◽  
Group A ◽  
Group B

AbstractBackgroundLeft ventricular rotation is physiologically affected by acute changes in preload. We investigated the acute effect of preload changes in chronically underloaded and overloaded left ventricles in children with shunt lesions.MethodsA total of 15 patients with atrial septal defects (Group A: 7.4 ± 4.7 years, 11 females) and 14 patients with patent arterial ducts (Group B: 2.7 ± 3.1 years, 10 females) were investigated using 2D speckle-tracking echocardiography before and after interventional catheterisation. The rotational parameters of the patient group were compared with those of 29 matched healthy children (Group C).ResultsMaximal torsion (A: 2.45 ± 0.9°/cm versus C: 1.8 ± 0.8°/cm, p < 0.05), apical peak systolic rotation (A: 12.6 ± 5.7° versus C: 8.7 ± 3.5°, p < 0.05), and the peak diastolic torsion rate (A: −147 ± 48°/second versus C: −110 ± 31°/second, p < 0.05) were elevated in Group A and dropped immediately to normal values after intervention (maximal torsion 1.5 ± 1.1°/cm, p < 0.05, apical peak systolic rotation 7.2 ± 4.1°, p < 0.05, and peak diastolic torsion rate −106 ± 35°/second, p < 0.05). Patients in Group B had decreased maximal torsion (B: 1.8 ± 1.1°/cm versus C: 3.8 ± 1.4°/cm, p < 0.05) and apical peak systolic rotation (B: 8.3 ± 6.1° versus C: 13.9 ± 4.3°, p < 0.05). Defect closure was followed by an increase in maximal torsion (B: 2.7 ± 1.4°/cm, p < 0.05) and the peak diastolic torsion rate (B: −133 ± 66°/second versus −176 ± 84°/second, p < 0.05).ConclusionsPatients with chronically underloaded left ventricles compensate with an enhanced apical peak systolic rotation, maximal torsion, and quicker diastolic untwisting to facilitate diastolic filling. In patients with left ventricular dilatation by volume overload, the peak systolic apical rotation and the maximal torsion are decreased. After normalisation of the preload, they immediately return to normal and diastolic untwisting rebounds. These mechanisms are important for understanding the remodelling processes.

Masked left ventricular restriction in elderly patients with atrial septal defects: A contraindication for closure?

2001 ◽  
Vol 52 (2) ◽  
pp. 177-180 ◽  
Author(s):  
Peter Ewert ◽  
Felix Berger ◽  
Nicole Nagdyman ◽  
Oliver Kretschmar ◽  
Sven Dittrich ◽  
...  
Keyword(s):  
Elderly Patients ◽  
Left Ventricular ◽  
Septal Defects ◽  
Atrial Septal Defects

scholarly journals Influence of Left Ventricular Stiffness on Hemodynamics in Patients With Untreated Atrial Septal Defects

2015 ◽  
Vol 79 (8) ◽  
pp. 1823-1827 ◽  
Author(s):  
Clara Kurishima ◽  
Ryo Inuzuka ◽  
Seiko Kuwata ◽  
Yoichi Iwamoto ◽  
Masaya Sugimoto ◽  
...  
Keyword(s):  
Left Ventricular ◽  
Septal Defects ◽  
Atrial Septal Defects ◽  
Left Ventricular Stiffness

Left ventricular rotational deformation changes by speckle tracking imaging before and 24 hours after transcatheter closure of large secundum atrial septal defects in children

2020 ◽  
Vol 37 (7) ◽  
pp. 1065-1071
Author(s):  
Amal Mahmoud El‐Sisi ◽  
Abd El‐Moneam Ahmed Mohammed Gabr ◽  
Ali Abdellatif Afia ◽  
Hassan Saad Abu‐Seif ◽  
Hala M. Agha ◽  
...  
Keyword(s):  
Speckle Tracking ◽  
Transcatheter Closure ◽  
Left Ventricular ◽  
Speckle Tracking Imaging ◽  
Septal Defects ◽  
Atrial Septal Defects ◽  
Rotational Deformation
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