The role of clinical and laboratory tests along with uterine artery Doppler indices in the prediction of pre-eclampsia and pregnancy outcome in Egypt

Background: The uterine artery Doppler has potentials for screening for complications of impaired placentation. The purpose of study was to assess the role of uterine artery color Doppler waveform analysis in second trimester for the prediction of preeclampsia in a high-risk pregnancy between 18-24 weeks of gestation.Methods: 100 women with moderate or high-risk factors for developing preeclampsia reporting to Obstetrics and Gynaecology department of Government Medical College and Hospital, Sector 32, Chandigarh were enrolled for present study. Transabdominal uterine artery doppler measurements was done at 18-24weeks of gestation in these patients. Doppler . The Doppler indices generated automatically from the machine , the Pulsatility Index (PI), Resistance Index (RI) , presence or absence of diastolic notch and S/D Ratio were recorded, and average was calculated.Results: Out of 100 patients there were 46 primigravidas with no additional risk factors, 22 pateints with two or more risk factors and there were no patients who had three or more risk factors in present study population. Preeclampsia is seen more commonly in primigravida and primigravida is considered as moderate risk factor for preeclampsia. It was found that an elevated second trimester uterine artery RI was significantly associated with developing preeclampsia later in pregnancy. The sensitivity and specificity of uterine artery Doppler velocimetry were found to be 84% and 55% respectively. Receiver operator characteristics (ROC) curves were created to demonstrate the prognostic value of RI and PI of uterine artery doppler indices at 18-24 weeks of gestation for the development preeclampsia. In addition, there were statistically significant positive correlations between mean RI of uterine artery doppler study and patients who developed preeclampsia. With a sensitivity of 84.21% it could identify 31% of the cases of preeclampsia at a false positive rate of 44.4%.Conclusions: Uterine artery doppler study can be used as a predictor of moderate strength for preeclampsia.

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Role of Uterine Artery Doppler in Second Trimester in Predicting Adverse Pregnancy Outcome

Indian Journal of Obstetrics and Gynecology ◽

10.21088/ijog.2321.1636.5417.5 ◽

2017 ◽

Vol 5 (4) ◽

pp. 471-478

Author(s):

C.C. Nandhini ◽

◽

D.S. Kavitha ◽

Keyword(s):

Pregnancy Outcome ◽

Uterine Artery ◽

Adverse Pregnancy Outcome ◽

Second Trimester ◽

Uterine Artery Doppler ◽

Adverse Pregnancy

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Correlation between First-Trimester Maternal Serum Markers, Second-Trimester Uterine Artery Doppler Indices and Pregnancy Outcome

Gynecologic and Obstetric Investigation ◽

10.1159/000303260 ◽

2010 ◽

Vol 70 (2) ◽

pp. 126-131 ◽

Cited By ~ 13

Author(s):

Banu Dane ◽

Cem Dane ◽

Murat Kiray ◽

Ahmet Cetin ◽

Macit Koldas ◽

...

Keyword(s):

Pregnancy Outcome ◽

Uterine Artery ◽

First Trimester ◽

Serum Markers ◽

Maternal Serum ◽

Second Trimester ◽

Uterine Artery Doppler ◽

Doppler Indices

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Role of pregnancy associated plasma protein-A and doppler velocimetry in the assessment of fetomaternal outcome in high risk pregnancy

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20191955 ◽

2019 ◽

Vol 8 (5) ◽

pp. 1981

Author(s):

Asmita Kaundal ◽

Usha Gupta ◽

Jayashree Bhattcharjee

Keyword(s):

High Risk ◽

Pregnancy Outcome ◽

Plasma Protein ◽

Uterine Artery ◽

Protein A ◽

High Risk Population ◽

Risk Population ◽

Uterine Artery Doppler ◽

Adverse Pregnancy

Background: The study aimed at defining the role of Pregnancy associated plasma protein-A (PAPP-A) and uterine artery doppler (Ut.A.PI) in the development of adverse pregnancy outcome (APO) in high risk pregnancies.Methods: This was an observational study where 100 singleton pregnancies at high risk of development of APO, between 11 to 13 + 6 weeks POG were enrolled. PAPP-A levels were measured at 11 to 13 + 6 weeks POG and uterine artery doppler PI was measured at 20 weeks. Women were followed till delivery. Pregnancy outcome were seen and a cut off at which APO developed was derived.Results: In this study women with lower mean PAPP-A (0.75±0.19 MOM versus 1.23±0.31MOM) (p<0.001) values and higher Ut.A.PI (1.43±0.35MOM versus 0.99±0.25MOM) (p<0.001) developed APO. Cut off value for PAPP-A and Ut.A.PI was determined and was found to be ≤11.65 µg/ml (≤0.79MoM) and >1.42 (>1.19MoM) respectively which was higher than what is determined in other studies done on low risks populations thereby suggesting for an intervention or more meticulous observations at a higher cut offs.Conclusions: PAPP-A and uterine artery doppler are already being used for the screening of preeclampsia in most of the countries but not for other adverse pregnancy outcomes. PAPP-A levels along with the uterine artery PI in predicting APO in high risk women has high negative predictive value. Hence can be uses as a screening method in high risk population whether they should be used for low risk population also needs further evaluation.

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