Comparison of differential renal function using technetium-99m mercaptoacetyltriglycine (MAG3) and technetium-99m dimercaptosuccinic acid (DMSA) renography in a paediatric population

2008 ◽  
Vol 38 (8) ◽  
pp. 857-862 ◽  
Author(s):  
Gillian Ritchie ◽  
Alistair G. Wilkinson ◽  
Robin J. Prescott
Keyword(s):  
Renal Function ◽  
Paediatric Population ◽  
Dimercaptosuccinic Acid ◽  
Technetium 99M ◽  
Differential Renal Function ◽  
Technetium 99M Dimercaptosuccinic Acid

scholarly journals Influence of splenectomy on the biodistribution of technetium-99m dimercaptosuccinic acid (99mTc-DMSA) in rats

2008 ◽  
Vol 51 (spe) ◽  
pp. 197-202 ◽  
Author(s):  
Maria Kadja Meneses Torres Açucena ◽  
Kércia Regina Santos Gomes Pereira ◽  
Arthur Villarim Neto ◽  
Amália Cínthia Meneses Rêgo ◽  
Mario Bernardo-Filho ◽  
...  
Keyword(s):  
Renal Function ◽  
Wistar Rats ◽  
T Test ◽  
Dimercaptosuccinic Acid ◽  
Serum Urea ◽  
Technetium 99M ◽  
Technetium 99M Dimercaptosuccinic Acid ◽  
And Control

This study aimed to evaluate if the splenectomy alters the biodistribution of 99mTc-DMSA and renal function in Wistar rats. The animals were separated in the groups: splenectomy (n = 6) and control (n = 6). After splenectomy (15 days), the administration of 0.1ml of 99mTc-DMSA IV (0.48 MBq) was carried out. Thirty minutes later, kidney, heart, lung, thyroid, stomach, bladder and femur and samples of blood were isolated. The organs were weighed, counted and the percentage of radioactivity /g (%ATI/g) determined. Serum urea and creatinine, hematocrit, leukocytes and platelets were measured. Statistics by t test (p<0.05) was done. There was a significant reduction in %ATI/g in kidney and blood (p<0.05) of splenectomized animals, a significant increase (p<0.05) of urea (88.8 ± 18.6 mg/dL) and creatinine (0.56 ± 0.08 mg/dL), compared to the controls (51.5±1.6, 0.37±0.02mg/dL, respectively), as well as increase in platelets and leucocytes, and hematocrit reduction. The analysis of the results indicates that in rats, splenectomy seems to alter the renal function and the uptake of 99mTc-DMSA.

Assessment of various parameters in the estimation of differential renal function using technetium-99m mercaptoacetyltriglycine

1999 ◽  
Vol 26 (2) ◽  
pp. 155-162 ◽  
Author(s):  
Mark F. Lythgoe ◽  
Isky Gordon ◽  
Zambia Khader ◽  
Terry Smith ◽  
Peter J. Anderson
Keyword(s):  
Renal Function ◽  
Technetium 99M ◽  
Differential Renal Function

scholarly journals Role of 99mTc-(V)DMSA in Detecting Tumor Cell Proliferation

2007 ◽  
Vol 2 ◽  
pp. 117739010700200 ◽  
Author(s):  
Fatma Al-Saeedi
Keyword(s):  
Cell Proliferation ◽  
Tumor Cell ◽  
Tumor Cells ◽  
Dimercaptosuccinic Acid ◽  
Cell Detection ◽  
Tumor Cell Proliferation ◽  
Technetium 99M ◽  
Tumor Cell Detection ◽  
Technetium 99M Dimercaptosuccinic Acid

Pentavalent technetium-99m dimercaptosuccinic acid (99mTc-(V)DMSA) is a tumor-seeking agent which was introduced to evaluate, image, and manage many types of cancers. In this review, the beginning of, and the most recent applications of using this agent was appraised. The relation with tumor cell detection and proliferation was reported and several mechanisms of uptake of 99mTc-(V)DMSA in tumor cells are described.

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