scholarly journals Study of peripapillary retinal nerve fiber layer thickness in patients of type 2 diabetes mellitus and its correlation with glycemic control

2021 ◽  
Vol 9 (1) ◽  
pp. 9
Author(s):  
Valerie Menezes ◽  
UgamP S. Usgaonkar ◽  
Akshaya Nagvenkar
2009 ◽  
Vol 19 (6) ◽  
pp. 1034-1038 ◽  
Author(s):  
M. Necati Demir ◽  
Ümit Ekşioğlu ◽  
Mustafa Altay ◽  
Özlem Tök ◽  
F. Gül Yilmaz ◽  
...  

2010 ◽  
Vol 2010 ◽  
pp. 1-6 ◽  
Author(s):  
Masahiko Sugimoto ◽  
Mikio Sasoh ◽  
Masashi Ido ◽  
Chisato Narushima ◽  
Yukitaka Uji

Purpose. To assess an effect of glycemic control on retinal nerve fiber layer (RNFL) in type 2 diabetes mellitus.Methods. Thirty-eight eyes of 38 patients with type 2 diabetes undergoing blood glucose regulation were enrolled. All patients were examined at (1) initial visit, (2) 1 month, (3) 2 months, and (4) 4-month after the initial examination. On each occasion, glycosylated hemoglobin (HbA1c) levels and optical coherence tomography (OCT) scanning for RNFL thickness were evaluated. 360 degree circular OCT scans with a diameter of 3.4 mm centered on the optic disc were performed.Results. Significant RNFL decrease was seen in the superior area between initial and 4 months examination (). The relationship between the changes in HbA1c and the changes in RNFL thickness was observed in superior, temporal, and inferior area () at 4 months.Conclusions. This study suggests that the glycemic control affects RNFL within 4 months.


2018 ◽  
Vol Volume 12 ◽  
pp. 419-425
Author(s):  
Rania Fahmy ◽  
Ramesa Bhat ◽  
Manar Al-Mutairi ◽  
Feda Aljaser ◽  
Afaf El-Ansary

2017 ◽  
Vol Volume 11 ◽  
pp. 1135-1141 ◽  
Author(s):  
Alexandros Takis ◽  
Dimitrios Alonistiotis ◽  
Nikolaos Ioannou ◽  
Evgenia Kontou ◽  
Maria Mitsopoulou ◽  
...  

2021 ◽  
Vol 14 (5) ◽  
pp. 750-758
Author(s):  
Jia-Xin Han ◽  
◽  
Huan-Huan Liang ◽  
Jian-Xin Guo ◽  
◽  
...  

AIM: To investigate the change of ocular surface and corneal nerve and their correlation in patients suffering from type 2 diabetes mellitus under different degrees of retinopathy. METHODS: Totally 129 type 2 diabetes mellitus patients (257 eyes) were included. They were divided into three groups: no diabetic retinopathy (NDR) group (33 cases, 66 eyes), non-proliferative diabetic retinopathy (NPDR) group (32 cases, 64 eyes), and proliferative diabetic retinopathy (PDR) group (34 cases, 67 eyes). Healthy normal individuals were enrolled as controls (30 cases, 60 eyes). Ocular Surface Disease Index (OSDI) questionnaire was completed by all subjects, and dry eye analyzer was applied to examine tear meniscus height (TMH), first tear break-up time (FTBUT), average tear break-up time (ATBUT), tear film lipid layer thickness classification, and meibomian gland loss (MGL) score. Corneal nerve fiber density (CNFD), corneal nerve branch density (CNBD), corneal nerve fiber length (CNFL), and corneal nerve fiber tortuosity (CNFT) were examined by in vivo confocal microscopy (IVCM). The differences and correlation among these parameters were analyzed. RESULTS: Total OSDI score, TMH, FTBUT, ATBUT, tear film lipid layer thickness, MGL score, CNFD, CNBD, CNFL, and CNFT were statistically different among the four groups (P<0.05). In NDR group, CNFL was positively correlated with TMH (r=0.493, both P<0.01) and ATBUT (r=0.437, P<0.05). CNFL in NPDR group was positively correlated with TMH (r=0.642, P<0.01) and ATBUT (r=0.6, P<0.01). CNFL in PDR group was positively correlated with TMH (r=0.364, P<0.05) and ATBUT (r=0.589, P<0.01), with low negative correlation with MGL score (r=-0.331, P<0.05). CONCLUSION: With the progression of diabetic retinopathy, TMH, BUT, lipid layer thickness, CNFL, CNFD, and CNBD gradually decreased, while total OSDI score, MGL score, and CNFT increased. CNFL is correlated with TMH and ATBUT in diabetic patients.


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