Safety of COVID-19 vaccine in the patient with history of drug allergy: An issue to be monitored

2021 ◽  
Vol 35 (1) ◽  
pp. 46
Author(s):  
Pathum Sookaromdee ◽  
Viroj Wiwanitkit
Keyword(s):  
Drug Allergy ◽  
History Of

АЛЛЕРГИЯ К ЛИМОНУ: ОПИСАНИЕ СЛУЧАЯ ОРАЛЬНОГО АЛЛЕРГИЧЕСКОГО СИНДРОМА В СОЧЕТАНИИ С АЛЛЕРГИЧЕСКИМ СРЕДНИМ ОТИТОМ И ЛАБИРИНТИТОМ У БОЛЬНОЙ С ПОЛИСЕНСИБИЛИЗАЦИЕЙ И МНОЖЕСТВЕННЫМИ ПРОЯВЛЕНИЯМИ АЛЛЕРГИИ

2019 ◽  
pp. 25-32
Author(s):  
O.S. Prilutskiy ◽  
Yu.A. Lyhina
Keyword(s):  
Drug Allergy ◽  
Allergic Rhinoconjunctivitis ◽  
Oral Allergy Syndrome ◽  
Plant Origin ◽  
Pollen Allergens ◽  
History Of ◽  
Skin Prick Tests ◽  
The Individual

Оральный аллергический синдром представляет собой IgEопосредованную аллергическую реакцию на продукты питания растительного происхождения у лиц с сенсибилизацией к различным пыльцевым аллергенам. Впервые описан клинический случай орального аллергического синдрома при употреблении в пищу лимона у женщины 25 лет. Кроме того, в анамнезе у больной зарегистрированы сезонный аллергический риноконъюнктивит, бронхиальная астма, контактный аллергический дерматит, проявления лекарственной аллергии в виде крапивницы, диареи и др. Установлена сенсибилизация ко многим группам аллергенов и наличие явлений аллергического среднего отита и вызванного аллергенами лабиринтита. Установлена целесообразность аллергенспецифической диагностики с использованием различных методов (лабораторных и прик, прикприктестов) для назначения индивидуальной диеты и гипоаллергенного режима.Oral allergic syndrome is an IgEmediated allergic reaction to foods of plant origin in persons with sensitization to various pollen allergens. A clinical case of oral allergy syndrome caused by consumption of lemon in a 25yearold woman with sensitization to many groups of allergens and presence of allergic otitis media and allergyinduced labyrinthitis is presented. The patient had a history of seasonal allergic rhinoconjunctivitis, bronchial asthma, contact allergic dermatitis, urticaria as a manifestation of drug allergy. In vivo (skin prick tests, prickprick tests) and in vitro allergen specific diagnostics allowed to work out the individual diet and a hypoallergenic regime in this case.

scholarly journals Antihistamines in Clinical Dentistry offering a Choice for Second Possibility in Reported Cases of Allergy to Local Anesthetics: Report of Two Cases and Literature Review

2014 ◽  
Vol 5 (1) ◽  
pp. 35-38
Author(s):  
Shahanavaj Imam Husen Khaji
Keyword(s):  
Literature Review ◽  
Local Anesthetic ◽  
Local Anesthetics ◽  
Drug Allergy ◽  
Dental Treatment ◽  
Present Report ◽  
Chemical Structures ◽  
Anesthetic Agents ◽  
History Of ◽  
Treatment Procedures

ABSTRACT Drug allergy encompasses a spectrum of immunologically mediated hypersensitivity reaction with varying mechanisms and clinical presentation. Type of adverse drug reaction not only affects patient's quality of life, but may also lead to delayed treatment, unnecessary investigations and even mortality. The most effective strategy for the management of drug allergy is the avoidance or discontinuation of the offending drug. When available, alternative medications with unrelated chemical structures should be substituted. Patients who presents with history of allergy to local anesthetics are common in dental practices. In the present report, retrospective documented history of allergy to local anesthetics (lidocaine) in two patients (50 years/female, 35 years/male) were evaluated critically and needful dental treatment procedures were carried out using antihistamines pheniramine maleate: 22.75 mg/ml; DPH HCl: 1%) as local anesthetic agents. In both the cases, antihistamines proved to be beneficial, effective, devoid of complications. In conclusion, use of antihistaminic drugs in patients with documented history of allergy could be an alternative drug of choice having local anesthetic properties for minor dental treatment procedures in routine dental practice. How to cite this article Khaji SIH. Antihistamines in Clinical Dentistry offering a Choice for Second Possibility in Reported Cases of Allergy to Local Anesthetics: Report of Two Cases and Literature Review. Int J Head Neck Surg 2014;5(1):35-38.

scholarly journals Ciprofloxacin and Metronidazole Allergy- A Case Report

2021 ◽  
Vol 6 (4) ◽  
pp. 87-92
Author(s):  
Rashi Bahuguna ◽  
Devesh Joshi ◽  
Madhulata Rana
Keyword(s):  
Intestinal Obstruction ◽  
Drug Administration ◽  
Drug Allergy ◽  
Complete Blood Count ◽  
Mean Corpuscular Hemoglobin ◽  
Hypersensitivity Reactions ◽  
Corpuscular Hemoglobin ◽  
Function Tests ◽  
History Of ◽  
Subacute Intestinal Obstruction

Fluoroquinolones are well-tolerated antibiotics widely used for treating infections. According to the literature, ciprofloxacin is mostly involved in Drug-induced hypersensitivity reactions. The various reactions that are reported in various case reports due to ciprofloxacin include Steven Johnson syndrome, eczema, erythroderma, maculopapular rashes. Metronidazole is a 5-nitroimidazole compound introduced in 1959 to treat Trichomonas vaginalis infections. Ciprofloxacin and Metronidazole hypersensitivity is not very frequent it is usually well tolerated but allergic reactions to these drugs occur due to their increased use either alone or in combination. An 83-year-old female was admitted to the private ward of surgery at Shri Mahant Indiresh hospital with chief complaints of abdominal pain and chronic constipation as the patient was not passing stools for 10 days. The patient was diagnosed with Subacute intestinal obstruction (SAIO) based on various laboratory findings and the symptomatic treatment was given treatment. Hypersensitivity reactions can be of two types immediate that occurs within few hours of drug administration and delayed that occurs within 24-48 hours of drug administration. Here in this case the person developed vomiting immediately after few hours of Ciprofloxacin administration so it is an immediate IgE mediated anaphylactic reaction. Metronidazoleis causing Type 4 Delayed hypersensitivity reaction in this patient as rashes and itching developed the next day after administration of metronidazole drug. Healthcare professionals should maintain the record of a medication history of the patient to identify any drug allergy so that it can be avoided in the future and in case of any ADR it should be reported. The patient should be advised to go for a sensitivity test to check which drug he/ she is allergic to and should avoid taking that medication. The patient should tell his/ her history of drug allergy to the doctor so that doctor doesn’t prescribe that medication. Keywords: CBC-Complete Blood Count, RFT-Renal Function tests, LFT-Liver function tests, Hb-Hemoglobin, SGOT-Serum Glutamic oxaloacetic transaminases, ALP-Alkaline phosphatase, MCH-mean corpuscular Hemoglobin, MCHC-Mean corpuscular hemoglobin concentration, RBC-Red Blood Cells, SAIO-Subacute intestinal obstruction, USG- Ultrasound.

Drug allergy

2019 ◽  
Vol 40 (6) ◽  
pp. 474-479
Author(s):  
Paul A. Greenberger
Keyword(s):  
Cystic Fibrosis ◽  
Drug Allergy ◽  
Skin Testing ◽  
Stevens Johnson Syndrome ◽  
Epstein Barr Virus Infection ◽  
Drug Reactions ◽  
Specific Patient ◽  
Increased Risk ◽  
History Of ◽  
Hiv Aids

Drug allergy describes clinical adverse reactions that are proved or presumed to be immunologically based. Allergic drug reactions do not resemble pharmacologic actions of the incriminated drug and may occur at fractions of what would be the therapeutic dosage. Allergic drug reactions are unpredictable; nevertheless, there is increased risk of drug hypersensitivity in (1) patients with cystic fibrosis who receive antibiotics; (2) patients with human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) who receive trimethoprim-sulfamethoxazole or if human leukocyte antigen (HLA)-B*5701+ and receive the antiretroviral agent abacavir; (3) other genetically susceptible populations, e.g., Han-Chinese with HLA-B*1502+ who develop Stevens-Johnson syndrome and toxic epidermal necrolysis from carbamazepine, with HLA-B*5801+ who are at increased risk for such reactions from allopurinol, those with HLA-A*32:01 and receive vancomycin and develop drug reaction with eosinophilia and systemic symptoms syndrome; and (4) patients with a history of compatible allergic reactions to the same medication, similar class, or potentially unrelated medication. Specific patient groups at higher risk for drug allergy include patients with Epstein-Barr virus infection, chronic lymphatic leukemia, HIV/AIDS, cystic fibrosis, patients with seizures who are being treated with anti-epileptic medications, and patients with asthma (especially severe asthma) who are at increased risk of anaphylaxis from any cause, including drugs, compared with patients without asthma. In patients with a history of penicillin allergy, skin testing helps clarify the current level of risk for anaphylaxis by using the major (penicilloyl polylysine) and minor penicillin determinants in which sensitivity is 99%. If penicilloyl polylysine and penicillin G are used for skin testing, then the sensitivity is approximately 85‐95%. When skin test results are negative, graded challenges are performed to administer optimal or truly essential antibiotics.

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