scholarly journals Bilateral proptosis in a child: A rare presentation of acute lymphoblastic leukemia

2018 ◽  
Vol 13 (4) ◽  
pp. 511
Author(s):  
Julius Scott ◽  
PonRamya Sivaperumal ◽  
SnehaMagatha Latha ◽  
Sowmiya Narayani
2017 ◽  
Vol 2017 ◽  
pp. 1-3 ◽  
Author(s):  
Khalid Mahmood ◽  
Muhammad Ubaid ◽  
Syeda Taliya Rizvi

Acute lymphoblastic leukemia is characterized by unchecked proliferation of malignant lymphoblasts which replaces the normal bone marrow culminating in anemia due to red blood cells inadequacy as well as in easy bruising/bleeding secondary to insufficient platelets production. Even the white blood cells which are produced excessively are immature and abnormal. ALL is the most common hematological malignancy in children. Most commonly, patients present with lymphadenopathy, recurrent infections, bleeding, fatigue, and bone pains. Bone pains, often particularly involving long bones, occur in about 21–38% of cases and are due to overcrowding of bone marrow with malignant cells. Vast majority of children with ALL have thrombocytopenia and/or anemia with a normal or mildly elevated white blood cells count with the presence of lymphoblasts on peripheral smear. About 50% of children present with bleeding while about 75% of patients have platelet count 100,000/microL. Visceromegaly is not uncommon but osteolytic lesions and hypercalcemia are rather uncommon. We present a 22-year-old gentleman with generalized fatigue and bone pains without visceromegaly. There was severe hypercalcemia with normal parathyroid levels but multiple osteolytic lesions. Peripheral smear showed anemia without blasts, whereas a bone marrow biopsy revealed > 30% blasts with interspersed CD 10 positive cells.


2021 ◽  
Vol 9 (3) ◽  
pp. 138
Author(s):  
PaurnimaU Bodhankar ◽  
Divya Balakrishnan ◽  
Nadhna Basheer ◽  
Mahesh Gopalakrishnan ◽  
Giridhar Anantharaman

2018 ◽  
Vol 35 (2) ◽  
pp. 369-370 ◽  
Author(s):  
Kundan Mishra ◽  
Aditya Jandial ◽  
Rajeev Sandal ◽  
Deepesh Lad ◽  
Gaurav Prakash ◽  
...  

2021 ◽  
Vol 11 (8) ◽  
pp. 79-80
Author(s):  
Vipul Taneja ◽  
Goud Raghvendra ◽  
Kusum Mahajan

Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer. Survival probability of pediatric ALL had been 10-20%, but the most recent clinical trials with multiagent chemotherapy have achieved overall survival probability of better than 80%. This is achieved because of better supportive care, treatment stratification based on relapse risk, and the biological features of leukemic cells. Diagnosis of ALL was based principally on morphological identification of leukemic blasts in bone marrow, and immunophenotype assessment by flow cytometry is necessary, and most pediatric ALL cases are clinically classified as B-cell precursor, T-cell ALL, or mature B-cell types. Key words: Acute Lymphoblastic Leukemia, ALL, Unilateral Facial palsy, pediatric ALL.


2013 ◽  
Vol 03 (03) ◽  
pp. 257-259
Author(s):  
Tapas Kumar Sabui ◽  
Syamal Sardar ◽  
Sumanta Laha ◽  
Abhishek Roy

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