scholarly journals A pilot exploration using optical coherence tomography angiography analysis of capillary vascular density and foveal avascular zone for the diagnosis of uveal melanoma

2020 ◽  
Vol 0 (0) ◽  
pp. 0
Author(s):  
CarolL Shields ◽  
JasonL Chien ◽  
Alicia Valverde-Megias ◽  
Gwo-Farn Chien
Keyword(s):  
Optical Coherence Tomography ◽  
Uveal Melanoma ◽  
Optical Coherence Tomography Angiography ◽  
Foveal Avascular Zone ◽  
Vascular Density ◽  
Optical Coherence ◽  
Avascular Zone

scholarly journals Comparison of optical coherence tomography angiography results of adult patients with Familial Mediterranean fever and healthy individuals

2019 ◽  
Vol 11 ◽  
pp. 251584141989205
Author(s):  
Emine Esra Karaca ◽  
Dilay Ozek ◽  
Ahmet Omma ◽  
Ozlem Evren Kemer
Keyword(s):  
Optical Coherence Tomography ◽  
Familial Mediterranean Fever ◽  
Optical Coherence Tomography Angiography ◽  
Foveal Avascular Zone ◽  
Control Group ◽  
Vascular Density ◽  
Optical Coherence ◽  
Healthy Individuals ◽  
Avascular Zone ◽  
Mediterranean Fever

Purpose: The aim of this study is to assess the macular ultrastructure measuring by optical coherence tomography angiography in adult patients with Familial Mediterranean fever. Methods: Participants were 62 Familial Mediterranean fever patients and 54 healthy individuals in control group with similar age and sex. The superficial and deep vascular plexus structures covering the central fovea in an area of 6 mm × 6 mm were measured using AngioVue images taken with optical coherence tomography angiography. Vasculature structure, foveal avascular zone, acircularity index of foveal avascular zone (the ratio of the perimeter of foveal avascular zone and the perimeter of a circle with the equal area), and superficial and deep retinal plexus densities were measured. Results: The inferior deep vascular density was measured: 49.17% ± 8.59% in Familial Mediterranean fever patients, 55.56% ± 5.92% in the control group. The deep inferior-hemi vascular density was measured: 48.59% ± 10.34% in Familial Mediterranean fever patients, 56.54% ± 8.05% in the control group. Deep inferior and deep inferior-hemi vascular density was significantly reduced in Familial Mediterranean fever patients compared with healthy controls ( p = 0.04 and p = 0.03, respectively). Conclusion: The vascular abnormalities in optical coherence tomography angiography show subclinical signs of microangiopathy in Familial Mediterranean fever patients. This observation, which can be obtained only through optical coherence tomography angiography, may be an ocular hallmark for Familial Mediterranean fever disease.

scholarly journals Is the Retinal Vasculature Related to β-Peripapillary Atrophy in Nonpathological High Myopia? An Optical Coherence Tomography Angiography Study in Chinese Adults

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Jiao Sun ◽  
Jialin Wang ◽  
Ran You ◽  
Yanling Wang
Keyword(s):  
Optical Coherence Tomography ◽  
High Myopia ◽  
Optical Coherence Tomography Angiography ◽  
Vessel Density ◽  
Foveal Avascular Zone ◽  
Vascular Density ◽  
Retinal Vasculature ◽  
Optical Coherence ◽  
Peripapillary Atrophy ◽  
Avascular Zone

Purpose. The association between β-peripapillary atrophy and the retinal vasculature in nonpathological high myopia is unclear. The aim of this study is to investigate whether β-peripapillary atrophy contribute to the changes of the retinal vasculature using optical coherence tomography angiography. Methods. In a cross-sectional study, one hundred and thirty eyes with nonpathological high myopia were included. β-peripapillary atrophy was analysed using Image J software based on fundus photographs. A 3.0 × 3.0 mm2 grid and a 4.5 × 4.5 mm2 grid were used to scan parafoveal and peripapillary regions using optical coherence tomography angiography, respectively. Vessel density and fractal dimensions of the retina and foveal avascular zone were analysed and quantified using en face projection images. Correlations between the vascular density, foveal avascular zone, and β-peripapillary atrophy were determined. Results. Using multivariate analysis, β-peripapillary atrophy was negatively correlated with the vessel density in radial peripapillary capillaries (p=0.002) even after adjusting for other variables. This relationship was also confirmed in the macula (superficial retinal plexus: p<0.05; deep retinal plexus: p<0.05). The vessel densities in the nasal and inferior sectors were more strongly correlated with β-peripapillary atrophy. Conclusions. There was a negative correlation between β-peripapillary atrophy and the retinal vasculature in highly myopic eyes, especially in radial peripapillary capillaries and deep retinal plexus. β-peripapillary atrophy can be visualized and is a convenient structural feature that can benefit the early diagnosis and detection of chorioretinal atrophy in high myopia.

scholarly journals Retinal Morphological Alterations in Polycythemia Vera: An Optical Coherence Tomography Angiography Study

2021 ◽  
Author(s):  
Muberra Akdogan ◽  
Mustafa Dogan ◽  
Anar Alizade ◽  
Mehmet Cem Sabaner ◽  
Hamidu Hamisi Gobeka ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Polycythemia Vera ◽  
Optical Coherence Tomography Angiography ◽  
Foveal Avascular Zone ◽  
Vascular Density ◽  
Optical Coherence ◽  
Morphological Alterations ◽  
Avascular Zone ◽  
Group 2 ◽  
Group 1

Abstract PurposeInvestigation of retinal morphological alterations in patients with polycythemia vera (PV) using optical coherence tomography angiography (OCTA).Materials and MethodsThirty PV patients (group 1) who were followed-up at Afyonkarahisar Health Sciences University Hospital, Department of Hematology, and 30 normal subjects (group 2) who applied to Ophthalmology Department for routine eye examination were enrolled in this cross-sectional, single-centered study. Following a comprehensive ophthalmological examination, all participants underwent spectral-domain OCTA examination with Angio Retina mode (6x6 mm). Data were compared between groups for statistical significance.RESULTSThe male-to-female ratio was 1:1. Mean ages were 46.97±3.20 and 47.42±2.55 years in groups 1 and 2, respectively (P: 0.350). Compared to group 2, group 1 had higher values of superficial whole, parafoveal, deep foveal, perifoveal region vascular density, foveal avascular zone perimeter, and foveal vascular density in 300 μm wide regions around foveal avascular zone values, although there were no statistically significant differences. Further, group 1 had statistically non-significantly decreased flow values and foveal avascular zone area compared to group 2. The superficial foveal vascular density was statistically significantly higher in group 1 than in group 2 (P: 0.032).CONCLUSIONFor the first time, the present study has revealed association of PV with substantial increase in the vascular density almost all around the foveal region. This suggests consideration of potential hyperviscosity impact on the vessel density during macular microcirculation assessment of patients with PV.

Foveal avascular zone in oculocutaneous albinism

2021 ◽  
Vol 14 (5) ◽  
pp. e240208
Author(s):  
Hana A Mansour ◽  
Sami Uwaydat ◽  
Muhamad H Yunis ◽  
Ahmad M Mansour
Keyword(s):  
Optical Coherence Tomography ◽  
Optical Coherence Tomography Angiography ◽  
Oculocutaneous Albinism ◽  
Foveal Avascular Zone ◽  
Optical Coherence ◽  
Retinal Capillary ◽  
Avascular Zone ◽  
Capillary Plexus ◽  
Foveal Hypoplasia

Optical coherence tomography angiography imaging in two patients with oculocutaneous albinism, one with severe nystagmus, showed persistence of both the superficial and the deep retinal capillary plexus adding another vascular feature to the foveal hypoplasia.

scholarly journals Automatic segmentation of foveal avascular zone based on adaptive watershed algorithm in retinal optical coherence tomography angiography images

2021 ◽  
Author(s):  
Jian Liu ◽  
Shixin Yan ◽  
Nan Lu ◽  
Dongni Yang ◽  
Chunhui Fan ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Healthy Subjects ◽  
Optical Coherence Tomography Angiography ◽  
Automatic Segmentation ◽  
Qualitative Evaluation ◽  
Foveal Avascular Zone ◽  
Watershed Algorithm ◽  
Strong Positive Correlation ◽  
Optical Coherence ◽  
Avascular Zone

The size and shape of the foveal avascular zone (FAZ) have a strong positive correlation with several vision-threatening retinovascular diseases. The identification, segmentation and analysis of FAZ are of great significance to clinical diagnosis and treatment. We presented an adaptive watershed algorithm to automatically extract FAZ from retinal optical coherence tomography angiography (OCTA) images. For the traditional watershed algorithm, “over-segmentation” is the most common problem. FAZ is often incorrectly divided into multiple regions by redundant “dams”. This paper analyzed the relationship between the “dams” length and the maximum inscribed circle radius of FAZ, and proposed an adaptive watershed algorithm to solve the problem of “over-segmentation”. Here, 132 healthy retinal images and 50 diabetic retinopathy (DR) images were used to verify the accuracy and stability of the algorithm. Three ophthalmologists were invited to make quantitative and qualitative evaluations on the segmentation results of this algorithm. The quantitative evaluation results show that the correlation coefficients between the automatic and manual segmentation results are 0.945 (in healthy subjects) and 0.927 (in DR patients), respectively. For qualitative evaluation, the percentages of “perfect segmentation” (score of 3) and “good segmentation” (score of 2) are 99.4% (in healthy subjects) and 98.7% (in DR patients), respectively. This work promotes the application of watershed algorithm in FAZ segmentation, making it a useful tool for analyzing and diagnosing eye diseases.

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