Brainwashing assumed the proportions of a cultural fantasy during the Cold War period. The article examines the various political, scientific and cultural contexts of brainwashing, and proceeds to a consideration of the place of mind control in British spy dramas made for cinema and television in the 1960s and 1970s. Particular attention is given to the films The Mind Benders (1963) and The Ipcress File (1965), and to the television dramas Man in a Suitcase (1967–8), The Prisoner (1967–8) and Callan (1967–81), which gave expression to the anxieties surrounding thought-control. Attention is given to the scientific background to the representations of brainwashing, and the significance of spy scandals, treasons and treacheries as a distinct context to the appearance of brainwashing on British screens.