Potential mutagenic effects of the glyphosate herbicide on Gymnotus inaequilabiatus (Valenciennes, 1839)

This study analyzed the occurrence of nuclear damage in the red blood cells of Gymnotus inaequilabiatus (Valenciennes, 1839), exposed in vivo to the herbicide glyphosate. The fish were distributed in four groups, namely: control (without addition of herbicide) and contaminated groups with application of 65 µg/L (concentration allowed by CONAMA Resolution), 1 mg/L (maximum limit recommended by the World Health Organization - WHO and Food and Agriculture Organization - FAO) and 5 mg/L (overdose, five times higher than that by WHO and FAO). For the analysis of cell damage, the method of Nuclear Erythrocytic Abnormalities (NEA) was used, containing 1000 cells for duplicate elimination. An increase in cell damage was observed for 144 hours (6-days) of exposure in all controls. Even under a small concentration, there was a clear effect on segmented, renal, lobed formation and mainly on the formation of micronuclei. The high damage was caused in the first 48 hours and reduced after 144 hours, where the fish can have the herbicidal effect blocked. Studies that analyze the mechanisms of action of glyphosate-based herbicides are essential to determine the risks caused by biota, since there is a great divergence on the maximum tolerable limits in water, which affect quality and integrity of these ecosystems.

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TRENDS

PEDIATRICS ◽

10.1542/peds.10.5.619 ◽

1952 ◽

Vol 10 (5) ◽

pp. 619-623

Keyword(s):

United Nations ◽

The United States ◽

World Health ◽

United States Government ◽

Food And Agriculture ◽

Equatorial Africa ◽

Food And Agriculture Organization ◽

The United Nations ◽

Health Organization ◽

Emergency Fund

IT APPEARS timely to call attention again to the work and objectives of the United Nations International Children's Emergency Fund. Particularly noteworthy is the trend to use this fund more and more in efforts to help other nations help themselves. Thus the mass attack on tuberculosis, yaws and malaria are, it is hoped, bringing those diseases into proportions where their continued control can be more effectively managed. Similarly, increasing attention is being given to the training of professional and technical personnel. The plans and long-range purpose of the UNICEF have recently been described by Maurice Pate, Executive Director of the fund: "Five years ago, in May 1947, the United Nations International Children's Emergency Fund received its first pledge of support, a contribution of $15,000,000 from the United States Government. A number of other pledges and contributions soon followed, and procurement of supplies was begun. By the middle of 1948, those supplies were reaching several million children. "Those early beginnings were in the minds of many of us at the recent meeting of the Fund's 26-nation Executive Board (April 22-24), for on that occasion UNICEF's aid was extended to the only remaining area of need in which it had not been operating— Africa, south of the Sahara. "In the Belgian Congo, French Equatorial Africa, Liberia, Togoland, the Cameroons and West Africa, UNICEF, side by side with the World Health Organization and the Food and Agriculture Organization, will soon be working with the governments and people on a number of child-health projects. The largest of these is to be an attack on kwashiokor, a dietary deficiency disease that affects thousands of young children in these regions.

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