scholarly journals Transcription factors and neural stem cell self-renewal, growth and differentiation

2009 ◽  
Vol 3 (4) ◽  
pp. 412-424 ◽  
Author(s):  
Sohail Ahmed ◽  
HuiTheng Gan ◽  
Chen Sok Lam ◽  
Anuradha Poonepalli ◽  
Srinivas Ramasamy ◽  
...  
Keyword(s):  
Stem Cell ◽  
Transcription Factors ◽  
Neural Stem Cell ◽  
Self Renewal

scholarly journals Transcriptional regulation of neural stem cell expansion in adult hippocampus

2021 ◽  
Author(s):  
Nannan Guo ◽  
Kelsey McDermott ◽  
Yu-Tzu Shih ◽  
Haley Zanga ◽  
Debolina Ghosh ◽  
...  
Keyword(s):  
Stem Cell ◽  
Transcription Factors ◽  
Neural Stem Cell ◽  
Cell Expansion ◽  
Self Renewal ◽  
Stem Cell Expansion ◽  
Radial Glial ◽  
Adult Hippocampus ◽  
Favorable Conditions

Experience governs neurogenesis from radial-glial neural stem cells (RGLs) in the adult hippocampus to support memory. Transcription factors in RGLs integrate physiological signals to dictate self-renewal division mode. Whereas asymmetric RGL divisions drive neurogenesis during favorable conditions, symmetric divisions prevent premature neurogenesis while amplifying RGLs to anticipate future neurogenic demands. The identities of transcription factors regulating RGL symmetric self-renewal, unlike those that regulate RGL asymmetric self-renewal, are not known. Here, we show that the transcription factor Kruppel-like factor 9 (Klf9) is elevated in quiescent RGLs and inducible, deletion of Klf9 promotes RGL activation state. Clonal analysis and longitudinal intravital 2-photon imaging directly demonstrate that Klf9 functions as a brake on RGL symmetric self-renewal. In vivo translational profiling of RGLs lacking Klf9 generated a blueprint of RGL symmetric self-renewal for stem cell community. Together, these observations identify Klf9 as a transcriptional regulator of neural stem cell expansion in the adult hippocampus.

scholarly journals Transcriptional regulation of neural stem cell expansion in adult hippocampus

eLife ◽  
2022 ◽  
Vol 11 ◽  
Author(s):  
Nannan Guo ◽  
Kelsey D McDermott ◽  
Yu-Tzu Shih ◽  
Haley Zanga ◽  
Debolina Ghosh ◽  
...  
Keyword(s):  
Stem Cell ◽  
Transcription Factors ◽  
Neural Stem Cell ◽  
Cell Expansion ◽  
Acid Oxidation ◽  
Self Renewal ◽  
Stem Cell Expansion ◽  
Adult Hippocampus ◽  
Favorable Conditions

Experience governs neurogenesis from radial-glial neural stem cells (RGLs) in the adult hippocampus to support memory. Transcription factors in RGLs integrate physiological signals to dictate self-renewal division mode. Whereas asymmetric RGL divisions drive neurogenesis during favorable conditions, symmetric divisions prevent premature neurogenesis while amplifying RGLs to anticipate future neurogenic demands. The identities of transcription factors regulating RGL symmetric self-renewal, unlike those that regulate RGL asymmetric self-renewal, are not known. Here, we show in mice that the transcription factor Kruppel-like factor 9 (Klf9) is elevated in quiescent RGLs and inducible, deletion of Klf9 promotes RGL activation state. Clonal analysis and longitudinal intravital 2-photon imaging directly demonstrate that Klf9 functions as a brake on RGL symmetric self-renewal. In vivo translational profiling of RGLs lacking Klf9 generated a molecular blueprint for RGL symmetric self-renewal that was characterized by upregulation of genetic programs underlying Notch and mitogen signaling, cell-cycle, fatty acid oxidation and lipogenesis. Together, these observations identify Klf9 as a transcriptional regulator of neural stem cell expansion in the adult hippocampus.

scholarly journals Impaired KDM2B-mediated PRC1 recruitment to chromatin causes defective neural stem cell self-renewal and ASD/ID-like behaviors

iScience ◽  
2022 ◽  
pp. 103742
Author(s):  
Yuen Gao ◽  
Natalia Duque-Wilckens ◽  
Mohammad B. Aljazi ◽  
Adam J. Moeser ◽  
George I. Mias ◽  
...  
Keyword(s):  
Stem Cell ◽  
Neural Stem Cell ◽  
Self Renewal

Plasma-Treated Flexible Aminoclay-Decorated Electrospun Nanofibers for Neural Stem Cell Self-Renewal

2016 ◽  
Vol 16 (2) ◽  
pp. 1392-1395 ◽  
Author(s):  
Young-Chul Lee ◽  
Hyun Uk Lee ◽  
Minhyung Lee ◽  
Janghwan Kim ◽  
Yun Suk Huh
Keyword(s):  
Stem Cell ◽  
Neural Stem Cell ◽  
Electrospun Nanofibers ◽  
Self Renewal

scholarly journals Endogenous Hepatocyte Growth Factor Is a Niche Signal for Subventricular Zone Neural Stem Cell Amplification and Self-Renewal

Stem Cells ◽  
2009 ◽  
Vol 27 (2) ◽  
pp. 408-419 ◽  
Author(s):  
Camille Nicoleau ◽  
Omar Benzakour ◽  
Fabienne Agasse ◽  
Nathalie Thiriet ◽  
Jérôme Petit ◽  
...  
Keyword(s):  
Stem Cell ◽  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Neural Stem Cell ◽  
Subventricular Zone ◽  
Self Renewal ◽  
Hepatocyte Growth

Surrogate Measures of Adult Stem Cell Self-Renewal: The Neural Stem Cell Paradigm

2011 ◽  
pp. 163-179
Author(s):  
Loic P. Deleyrolle ◽  
Brent A. Reynolds ◽  
Florian A. Siebzehnrubl
Keyword(s):  
Stem Cell ◽  
Neural Stem Cell ◽  
Adult Stem Cell ◽  
Self Renewal ◽  
Surrogate Measures
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