Analysis of the mononuclear inflammatory cell infiltrate in the nontumorigenic, Pretumorigenic and tumorigenic keratinocytic hyperproliferative lesions of the skin

Abstract Context.—Deep penetrating nevus is a distinctive melanocytic lesion that may simulate melanoma both clinically and histologically. Objective.—To review clinical and histologic features of deep penetrating nevi and discuss their differential diagnosis, especially regarding melanoma. Data Sources.—The literature on deep penetrating nevi is reviewed and supplemented by our experiences with deep penetrating nevi. Conclusions.—One or more disturbing histologic features may frequently be found in deep penetrating nevi, including asymmetry, plump but fairly regular nests of melanocytes in the dermis, cytologic atypia with some nuclear pleomorphism, a small to medium-sized eosinophilic nucleolus, absence of maturation, occasional presence of normal dermal mitoses, and a patchy mononuclear inflammatory cell infiltrate. Although unusual, such histologic features should not be regarded as a sign of malignancy in deep penetrating nevi.

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Analysis of the mononuclear inflammatory cell infiltrate in the cirrhotic, Dysplastic nodules and hepatocellular carcinomas in patients with chronic hepatitis C infection

Cancer Biology & Therapy ◽

10.4161/cbt.4.10.1986 ◽

2005 ◽

Vol 4 (10) ◽

pp. 1075-1078 ◽

Cited By ~ 6

Author(s):

Mahmoud R. Hussein ◽

Rabab A. Ahmed

Keyword(s):

Chronic Hepatitis ◽

Hepatitis C ◽

Chronic Hepatitis C ◽

Inflammatory Cell ◽

Inflammatory Cell Infiltrate ◽

Cell Infiltrate ◽

Hepatitis C Infection ◽

Hepatocellular Carcinomas ◽

Dysplastic Nodules ◽

Mononuclear Inflammatory Cell

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Higher Number of EBI3 Cells in Mucosal Chronic Hyperplastic Candidiasis May Serve to Regulate IL-17-Producing Cells

Journal of Fungi ◽

10.3390/jof7070533 ◽

2021 ◽

Vol 7 (7) ◽

pp. 533

Author(s):

Ailish Williams ◽

Helen Rogers ◽

David Williams ◽

Xiao-Qing Wei ◽

Damian Farnell ◽

...

Keyword(s):

Oral Mucosa ◽

Oral Lichen Planus ◽

Inflammatory Cell ◽

Candida Infection ◽

Inflammatory Cell Infiltrate ◽

T Helper ◽

Cell Infiltrate ◽

High Prevalence ◽

Squamous Cell Papilloma ◽

Oral Lichen

Previous research into the inflammatory cell infiltrate of chronic hyperplastic candidosis (CHC) determined that the immune response is primarily composed of T cells, the majority of which are T helper (CD4+) cells. This present investigation used immunohistochemistry to further delineate the inflammatory cell infiltrate in CHC. Cells profiled were those expressing IL-17A cytokine, EBI3 and IL-12A subunits of the IL-35 cytokine, and FoxP3+ cells. Squamous cell papilloma (with Candida infection) and oral lichen planus tissues served as comparative controls to understand the local immune responses to Candida infection. The results demonstrated that Candida-induced inflammation and immune regulation co-exist in the oral mucosa of CHC and that high prevalence of cells expressing the EBI3 cytokine subunit may play an important role in this regulation. This balance between inflammation and immune tolerance toward invading Candida in the oral mucosa may be critical in determining progress of infection.

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