Prevalence and Clinical Impact of IgE-Mediated Food Allergy in School Children With Asthma: A Double-Blind Placebo-Controlled Food Challenge Study

Food allergy is an immune reaction that occurs frequently in pediatric age, its prevalence is higher in industrialized countries, affecting 8% of the population, the most frequently involved foods are milk, hen’s egg, soybeans, peanuts, fish, wheat, seafood and tree nuts. Food allergy can be divided into three groups: IgE-mediated, non-IgE-mediated, and mixed food allergy. The symptoms will depend on the immunological mechanisms and can be divided into immediate or no immediate, the immediate symptoms appear in the first two hours of intake and the no immediate symptoms after the second hour and up to 72 hours. Diagnosis of food allergy requires a medical history, physical examination and laboratory tests; misdiagnosis can lead to unnecessary elimination diets. The gold standard is the double-blind placebo controlled oral food challenge. The main treatment is food restriction, the nutritional and psychological implications that this entails must be taken into account; Another treatment option is oral immunotherapy, it is recommended in patients who cannot carry out an elimination diet and it has a significant impact on quality of life.

Download Full-text

Timing of Onset of Allergic Symptoms as a Response to a Double-Blind, Placebo-Controlled Food Challenge in Patients with Food Allergy Combined with a Radioallergosorbent Test and the Evaluation of Proliferative Lymphocyte Responses

International Archives of Allergy and Immunology ◽

10.1159/000236691 ◽

1994 ◽

Vol 104 (4) ◽

pp. 352-357 ◽

Cited By ~ 10

Author(s):

Osamu Fukutomi ◽

Naomi Kondo ◽

Hiroatsu Agata ◽

Shinji Shinoda ◽

Naoki Kuwabara ◽

...

Keyword(s):

Food Allergy ◽

Food Challenge ◽

Double Blind ◽

Double Blind Placebo ◽

Allergic Symptoms ◽

Radioallergosorbent Test ◽

Lymphocyte Responses ◽

Timing Of Onset

Download Full-text

Influence of Antihistamines on Basophil Activation Test in Food Allergy to Milk and Egg

Diagnostics ◽

10.3390/diagnostics11010044 ◽

2020 ◽

Vol 11 (1) ◽

pp. 44

Author(s):

Eleonora Nucera ◽

Riccardo Inchingolo ◽

Rosario Nicotra ◽

Manuela Ferraironi ◽

Anna Giulia Ricci ◽

...

Keyword(s):

Food Allergy ◽

Food Challenge ◽

Basophil Activation Test ◽

Basophil Activation ◽

Double Blind ◽

Positive Skin ◽

Activation Test ◽

History Of ◽

Ige Mediated ◽

Food Allergy Diagnosis

Background: The basophil activation test (BAT) is used to improve the accuracy of food allergy diagnosis. To date, the influence of antiallergic drugs on BAT reactivity is poorly investigated. The aim of the study was to investigate if BAT results were influenced by antihistamine intake for 3 months in a cohort of patients with IgE-mediated food allergy to milk or egg. Methods: A retrospective, single-center, observational study was performed. We enrolled subjects with history of hypersensitivity reaction after specific food ingestion, positive skin prick tests and specific IgEs, concomitant allergic rhinitis, and, contraindication to the double-blind, placebo-controlled food challenge due to personal history of systemic reactions related to the ingestion of culprit food. Validated allergens (α-lactoalbumin, β-lactoglobulin, casein, egg white, and yolk) for BAT were used. Results: Thirty-nine patients with well-documented food symptoms and positive allergological workup were included in the study. BAT was positive in 29 patients. The mean percentages of CD63+ expression to specific culprit allergen did not change after the administration of drugs. Conclusions: This was the first study assessing the effects of oral antihistamines on basophil reactivity in cow’s milk and egg food allergy. Antihistamines do not interfere with BAT results.

Download Full-text

The Effect of Wheat Allergy on the Course of Atopic Eczema in Patients over 14 Years of Age

Acta Medica (Hradec Kralove Czech Republic) ◽

10.14712/18059694.2016.41 ◽

2011 ◽

Vol 54 (4) ◽

pp. 157-162 ◽

Cited By ~ 3

Author(s):

Jarmila Čelakovská ◽

Květuše Ettlerová ◽

Karel Ettler ◽

Jaroslava Vaněčková ◽

Josef Bukač

Keyword(s):

Food Allergy ◽

Wheat Flour ◽

Atopic Eczema ◽

Challenge Test ◽

Food Challenge ◽

Wheat Allergy ◽

Double Blind ◽

Double Blind Placebo ◽

Food Challenge Test

Few studies concerning the importance of wheat allergy affecting the course of atopic eczema in adolescents and adult patients exist. Aim: The evaluation if wheat allergy can deteriorate the course of atopic eczema. Follow-up of patients with confirmed food allergy to wheat. Method: Altogether 179 persons suffering from atopic eczema were included in the study: 51 men and 128 women entered the study with an average age of 26.2 (s.d. 9.5 years) Dermatological and allergological examinations were performed, including skin prick tests, atopy patch tests, and specific serum IgE for wheat, open exposure test and double-blind, placebo-controlled food challenge test with wheat flour. Results: Wheat allergy affecting the coures of atopic eczema was confirmed in eight patients (4.5%) out of 179 patients enrolled in this study by double-blind, placebo controlled food challenge test. The course of atopic eczema showed a positive trend in patients with confirmed food allergy at 3, 6, 9, 12 month follow-up (statistical evaluation with paired t-test) after the elimination of wheat flour. Conclusion: Wheat allergy may play an important role in the worsening of atopic eczema (acting as a triggering exacerbating factor) only in a minority of adolescents and adult patients (4.5% in our study). The diagnostic methods (skin prick test, specific IgE, atopy patch test, history) cannot be used as separated tests for the determination of food allergy to wheat in patients with atopic eczema.Open exposure tests and double-blind, placebo-controlled food challenge should be used for the confirmation of wheat allergy affecting the course of atopic eczema.

Download Full-text