scholarly journals Critical mass for infinite-time aggregation in a chemotaxis model with indirect signal production

2017 ◽  
Vol 19 (12) ◽  
pp. 3641-3678 ◽  
Author(s):  
Youshan Tao ◽  
Michael Winkler
Keyword(s):  
Critical Mass ◽  
Infinite Time ◽  
Chemotaxis Model ◽  
Time Aggregation ◽  
Signal Production ◽  
Indirect Signal Production

scholarly journals Does indirectness of signal production reduce the explosion-supporting potential in chemotaxis–haptotaxis systems? Global classical solvability in a class of models for cancer invasion (and more)

2020 ◽  
pp. 1-34
Author(s):  
CHRISTINA SURULESCU ◽  
MICHAEL WINKLER
Keyword(s):  
Blow Up ◽  
Initial Boundary ◽  
Tumour Microenvironment ◽  
Cancer Invasion ◽  
Two Dimensional ◽  
Classical Solvability ◽  
Differential Equation Models ◽  
Signal Production ◽  
Initial Boundary Value ◽  
Indirect Signal Production

We propose and study a class of parabolic-ordinary differential equation models involving chemotaxis and haptotaxis of a species following signals indirectly produced by another, non-motile one. The setting is motivated by cancer invasion mediated by interactions with the tumour microenvironment, but has much wider applicability, being able to comprise descriptions of biologically quite different problems. As a main mathematical feature constituting a core difference to both classical Keller–Segel chemotaxis systems and Chaplain–Lolas type chemotaxis–haptotaxis systems, the considered model accounts for certain types of indirect signal production mechanisms. The main results assert unique global classical solvability under suitably mild assumptions on the system parameter functions in associated spatially two-dimensional initial-boundary value problems. In particular, this rigorously confirms that at least in two-dimensional settings, the considered indirectness in signal production induces a significant blow-up suppressing tendency also in taxis systems substantially more general than some particular examples for which corresponding effects have recently been observed.

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