scholarly journals Oropharyngeal Dysphagia: Rare Presenting Symptom of Statin-induced HMG CoA Reductase Necrotizing Autoimmune Myopathy

2017 ◽  
Vol 07 (04) ◽  
Author(s):  
Vatsal Bhatt ◽  
Clifford Stermer ◽  
Vivien Hsu ◽  
Ranita Sharma
Keyword(s):  
Oropharyngeal Dysphagia ◽  
Hmg Coa Reductase ◽  
Necrotizing Autoimmune Myopathy ◽  
Autoimmune Myopathy ◽  
Coa Reductase

scholarly journals Increased frequency of DRB1*11:01 in anti-HMG-CoA reductase-associated autoimmune myopathy

2012 ◽  
pp. n/a-n/a ◽  
Author(s):  
Andrew L. Mammen ◽  
Daniel Gaudet ◽  
Diane Brisson ◽  
Lisa Christopher-Stine ◽  
Thomas E. Lloyd ◽  
...  
Keyword(s):  
Hmg Coa Reductase ◽  
Autoimmune Myopathy ◽  
Coa Reductase

Statin-induced necrotising autoimmune myopathy: a rare complication of statin therapy

2021 ◽  
Vol 14 (4) ◽  
pp. e240865
Author(s):  
Muhammad Tauseef Ghaffar ◽  
Avinash Radhakrishna ◽  
Imran Ali ◽  
Byran Whelan
Keyword(s):  
Muscle Weakness ◽  
Rare Complication ◽  
Response To Treatment ◽  
Proximal Muscle Weakness ◽  
Proximal Muscle ◽  
Hmg Coa Reductase ◽  
Muscle Groups ◽  
Autoimmune Myopathy ◽  
Coa Reductase ◽  
Statin Use

Statin-induced necrotising autoimmune myopathy (SINAM), a rare complication of statin use, presents with significant proximal muscle weakness and raised creatine kinase (CK) levels (50–100 times). This is different from other musculoskeletal conditions caused by statin use. Anti-hydroxy-methyl-glutaryl-coenzyme A reductase (HMG-CoA) reductase antibody is usually positive in SINAM and it generally indicates good response to immunosuppressive medications. We report a case of a 52-year-old man who presented with a 2-month history of significant upper and lower extremity proximal muscle weakness and a CK level of >10 000. He was started on atorvastatin for myocardial infarction 3 years ago. MRI pelvis, including proximal thigh, showed diffuse muscle oedema to all muscle groups. Muscle biopsy was suggestive of necrotising myopathy. His HMG-CoA reductase antibody was also positive. His treatment regimen consisted of immunosuppressants, including steroids. He also required extensive physiotherapy and showed response to treatment when reviewed in the outpatient clinic 9 months later.

Reduction of HMG-CoA-reductase leads to improved cardiac function in doxorubicin-induced cardiomyopathy in mice

2008 ◽  
Vol 7 ◽  
pp. 202-203
Author(s):  
A RIAD ◽  
S BIEN ◽  
F ESCHER ◽  
D WESTERMANN ◽  
U LANDMESSER ◽  
...  
Keyword(s):  
Cardiac Function ◽  
Hmg Coa Reductase ◽  
Coa Reductase
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