Although several studies addressed the work-related shoulder pathology, there is still a lack of knowledge regarding the causal relationship between different factors in industrial/office activities and shoulder musculoskeletal disorders. The goal of this review is to evaluate in a realistic manner the role of the factors implicated in the shoulder disorders development in high-risk activities. This article reviews the actual state of information regarding the etiological relationship between physical and psychosocial stress and occupational musculoskeletal problems in shoulder area, emphasizing the relationship between ergonomic interventions on musculoskeletal system. Secondly, a comprehensive presentation of the pathophysiology and etiology of shoulder muscle problems is provided. Critical factors such as arm elevation, lack of rest, overloading of several muscles and mental stress during performed tasks are discussed in relation to shoulder musculoskeletal disorders development. Finally, using the available data, the authors present a thorough recommendation of mandatory redesign interventions with suggestions for future research in this area.