Recalcitrant Hyperkalaemia Associated with a Single Dose Administration of Zoledronic Acid for Treatment of Post-Menopausal Osteoporosis

2013 ◽  
Vol 01 (02) ◽  
Author(s):  
Jerry Yongqiang Chen Leon Siang Shen Foo
Keyword(s):  
Single Dose ◽  
Zoledronic Acid ◽  
Dose Administration ◽  
Single Dose Administration ◽  
Post Menopausal Osteoporosis ◽  
Post Menopausal ◽  
Menopausal Osteoporosis

scholarly journals Efficacy of single dose of zoledronic acid in treating post-menopausal osteoporosis

2019 ◽  
Vol 5 (4) ◽  
pp. 364-368
Author(s):  
Dr. S Veera Kumar ◽  
Dr. P Vasanthamani ◽  
Dr. S Makesh Ram ◽  
Dr C Srinivasa Cholan ◽  
Dr. Kathirazhagan S
Keyword(s):  
Single Dose ◽  
Zoledronic Acid ◽  
Post Menopausal Osteoporosis ◽  
Post Menopausal ◽  
Menopausal Osteoporosis

Symptomatic hypocalcemia following a single dose of zoledronic acid in a patient with bone metastases secondary to breast cancer

2020 ◽  
pp. 107815522094041
Author(s):  
Hasan Sözel ◽  
Fatih Yilmaz
Keyword(s):  
Breast Cancer ◽  
Vitamin D ◽  
Single Dose ◽  
Zoledronic Acid ◽  
Vitamin D Deficiency ◽  
Metastatic Breast ◽  
Post Menopausal Osteoporosis ◽  
Symptomatic Hypocalcemia ◽  
Precautionary Measures ◽  
Post Menopausal

Introduction The use of bisphosphonates is increasing, for treatment of hypercalcemia and pain in cancer, and post-menopausal osteoporosis and also to decrease the risk of skeletal morbidity in multiple myeloma and metastatic breast cancer. Case report A single dose of zoledronic acid was administered for hypercalcemia in a 54-year-old woman breast cancer patient with extensive bone metastasis. After the first dose, the patient developed symptomatic hypocalcemia. Management and outcome: Simultaneous hypocalcemia, hypophosphatemia, and vitamin D deficiency were detected in the patient. In the symptomatic process, intravenous, then oral replacement was performed. Discussion There is a need for taking precautionary measures such as vitamin D, serum phosphorus and, calcium monitoring and supplementation to prevent life-threatening complications, such as symptomatic hypocalcemia, especially in populations with vitamin D deficiency like ours.

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