scholarly journals <i>In-Vitro</i> Inhibitory Effect of Methanol Extracts of Chinese Herbal Drugs on Supercoiling Activity of Bacterial DNA Gyrase

2013 ◽  
Vol 04 (01) ◽  
pp. 19-23
Author(s):  
Hui Xu ◽  
Huizhi Chen ◽  
Pan Yao ◽  
Guodong Lin ◽  
Weiwen Chen
Keyword(s):  
Dna Gyrase ◽  
Inhibitory Effect ◽  
Herbal Drugs ◽  
Bacterial Dna ◽  
Methanol Extracts ◽  
Chinese Herbal ◽  
Chinese Herbal Drugs

scholarly journals In VitroandIn VivoCharacterization of the Novel Oxabicyclooctane-Linked Bacterial Topoisomerase Inhibitor AM-8722, a Selective, Potent Inhibitor of Bacterial DNA Gyrase

2016 ◽  
Vol 60 (8) ◽  
pp. 4830-4839 ◽  
Author(s):  
Christopher M. Tan ◽  
Charles J. Gill ◽  
Jin Wu ◽  
Nathalie Toussaint ◽  
Jingjun Yin ◽  
...  
Keyword(s):  
Broad Spectrum ◽  
Antibacterial Agents ◽  
Cell Activity ◽  
Dna Gyrase ◽  
Topoisomerase Iv ◽  
Bacterial Dna ◽  
Whole Cell ◽  
Content Type

ABSTRACTOxabicyclooctane-linked novel bacterial topoisomerase inhibitors (NBTIs) represent a new class of recently described antibacterial agents with broad-spectrum activity. NBTIs dually inhibit the clinically validated bacterial targets DNA gyrase and topoisomerase IV and have been shown to bind distinctly from known classes of antibacterial agents directed against these targets. Herein we report the molecular, cellular, andin vivocharacterization of AM-8722 as a representative N-alkylated-1,5-naphthyridone left-hand-side-substituted NBTI. Consistent with its mode of action, macromolecular labeling studies revealed a specific effect of AM-8722 to dose dependently inhibit bacterial DNA synthesis. AM-8722 displayed greater intrinsic enzymatic potency than levofloxacin versus both DNA gyrase and topoisomerase IV fromStaphylococcus aureusandEscherichia coliand displayed selectivity against human topoisomerase II. AM-8722 was rapidly bactericidal and exhibited whole-cell activity versus a range of Gram-negative and Gram-positive organisms, with no whole-cell potency shift due to the presence of DNA or human serum. Frequency-of-resistance studies demonstrated an acceptable rate of resistance emergencein vitroat concentrations 16- to 32-fold the MIC. AM-8722 displayed acceptable pharmacokinetic properties and was shown to be efficacious in mouse models of bacterial septicemia. Overall, AM-8722 is a selective and potent NBTI that displays broad-spectrum antimicrobial activityin vitroandin vivo.

scholarly journals Ischemic Stroke Associated with Cough and Cold Preparation Containing Methylephedrine and Supplement Containing Chinese Herbal Drugs

2010 ◽  
Vol 49 (4) ◽  
pp. 335-338 ◽  
Author(s):  
Noboru Imai ◽  
Nobuyasu Yagi ◽  
Takashi Konishi ◽  
Masahiro Serizawa ◽  
Masahiro Kobari
Keyword(s):  
Ischemic Stroke ◽  
Herbal Drugs ◽  
Chinese Herbal ◽  
Chinese Herbal Drugs

Adverse events and interactions due to Chinese herbal drugs in Italy. A three-year pharmacoepidemiology, pharmacogenomic and pharmacovigilance survey

2010 ◽  
Vol 2 (4) ◽  
pp. 211
Author(s):  
A. Vannacci ◽  
E. Gallo ◽  
F. Lapi ◽  
A. Pugi ◽  
E. Lucenteforte ◽  
...  
Keyword(s):  
Adverse Events ◽  
Herbal Drugs ◽  
Chinese Herbal ◽  
Chinese Herbal Drugs

scholarly journals Efficacy of Chinese herbal drugs for angina pectoris: frequentist network meta-analyses

The Lancet ◽  
2017 ◽  
Vol 390 ◽  
pp. S72
Author(s):  
Yongliang Jia ◽  
Siu-wai Leung
Keyword(s):  
Angina Pectoris ◽  
Herbal Drugs ◽  
Chinese Herbal ◽  
Chinese Herbal Drugs ◽  
Meta Analyses

scholarly journals In vitro inhibition of bacterial DNA gyrase by cinodine, a glycocinnamoylspermidine antibiotic.

1990 ◽  
Vol 34 (7) ◽  
pp. 1450-1452 ◽  
Author(s):  
M S Osburne ◽  
W M Maiese ◽  
M Greenstein
Keyword(s):  
Dna Gyrase ◽  
Bacterial Dna ◽  
In Vitro Inhibition

scholarly journals In VitroActivity of AZD0914, a Novel Bacterial DNA Gyrase/Topoisomerase IV Inhibitor, against Clinically Relevant Gram-Positive and Fastidious Gram-Negative Pathogens

2015 ◽  
Vol 59 (10) ◽  
pp. 6053-6063 ◽  
Author(s):  
Douglas J. Biedenbach ◽  
Michael D. Huband ◽  
Meredith Hackel ◽  
Boudewijn L. M. de Jonge ◽  
Daniel F. Sahm ◽  
...  
Keyword(s):  
Bacterial Species ◽  
Dna Gyrase ◽  
Species Group ◽  
Coagulase Negative Staphylococci ◽  
Topoisomerase Iv ◽  
Gram Positive ◽  
Bacterial Dna ◽  
Gram Negative ◽  
Content Type

ABSTRACTAZD0914, a new spiropyrimidinetrione bacterial DNA gyrase inhibitor with a novel mode of inhibition, has activity against bacterial species commonly cultured from patient infection specimens, including fluoroquinolone-resistant isolates. This study assessed thein vitroactivity of AZD0914 against key Gram-positive and fastidious Gram-negative clinical isolates collected globally in 2013. AZD0914 demonstrated potent activity, with MIC90s for AZD0914 of 0.25 mg/liter againstStaphylococcus aureus(n= 11,680), coagulase-negative staphylococci (n= 1,923), streptococci (n= 4,380), andMoraxella catarrhalis(n= 145), 0.5 mg/liter againstStaphylococcus lugdunensis(n= 120) andHaemophilus influenzae(n= 352), 1 mg/liter againstEnterococcus faecalis(n= 1,241), and 2 mg/liter againstHaemophilus parainfluenzae(n= 70). The activity againstEnterococcus faeciumwas more limited (MIC90, 8 mg/liter). The spectrum and potency of AZD0914 included fluoroquinolone-resistant isolates in each species group, including methicillin-resistant staphylococci, penicillin-resistant streptococci, vancomycin-resistant enterococci, β-lactamase-producingHaemophilusspp., andM. catarrhalis. Based on thesein vitrofindings, AZD0914 warrants further investigation for its utility against a variety of Gram-positive and fastidious Gram-negative bacterial species.

Knowledge modeling and acquisition of traditional Chinese herbal drugs and formulae from text

2004 ◽  
Vol 32 (1) ◽  
pp. 3-13 ◽  
Author(s):  
Cungen Cao ◽  
Haitao Wang ◽  
Yuefei Sui
Keyword(s):  
Herbal Drugs ◽  
Knowledge Modeling ◽  
Chinese Herbal ◽  
Chinese Herbal Drugs
Sign in / Sign up

Export Citation Format

Share Document